Expression of TNF‐<i>α</i> in oral lichen planus treated with fluocinolone acetonide 0.1%

Thongprasom, Kobkan; Dhanuthai, Kittipong; Sarideechaigul, Wilairat; Chaiyarit, Ponlatham; Chaimusig, Mantharop

doi:10.1111/j.1600-0714.2006.00392.x

Cited by 40 publications

(46 citation statements)

References 23 publications

(24 reference statements)

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“…TNF-α is involved in the inflammatory process of OLP in Thai patients. This finding was the first report regarding the potential of a topical steroid in affecting the expression of TNF-α in OLP lesions (6).…”

Section: Therapeutic Effects Of Steroids In Olpmentioning

confidence: 78%

“…Many factors are involved in the pathogenesis of OLP such as matrix metalloproteinases, chymase, tryptase and proinflammatory cytokines (5). Recently, TNF-α which is one of the proinflammatory cytokines has been reported to play a role in the pathogenesis and inflammatory process of OLP (6). The immunological abnormality leads to a delay in the growth of mucosal epithelium which is responsible for hyperkeratosis (7).…”

Section: Introductionmentioning

confidence: 99%

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Steriods in the treatment of lichen planus: a review

2008

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Steroids have been found to be effective in treating symptomatic oral lichen planus (OLP) by reducing pain and inflammation. In fact, systemic corticosteroids should be reserved for acute exacerbation, and multiple or widespread lesions. They may be indicated in patients whose condition is unresponsive to topical steroids. However, various potent topical steroids have been reported to be effective in the treatment of symptomatic OLP. They can be used as the first line drugs in the treatment of OLP with no serious side-effects. During the therapy, candidiasis was commonly found and in addition, bad taste, nausea, dry mouth, sore throat and swollen mouth may occur as minor side-effects from some topical steroids. Because OLP is a chronic disorder that requires long-term treatment, topical steroids are recommended for the treatment OLP because of minimal side-effects and the cost benefit. This manuscript reviews the use of steroids, especially its topical application, in the treatment of

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Section: Therapeutic Effects Of Steroids In Olpmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Steriods in the treatment of lichen planus: a review

2008

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“…21,24 In oral LP, levels of TNF-a decrease after steroid treatment. 25,26 There have also been reports of successful treatment of LP with the TNF-a inhibitor etanercept. 27 Based on these observations, the development of lichenoid reactions in patients taking TNF-a inhibitors is unexpected.…”

Section: Discussionmentioning

confidence: 97%

Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

Asarch

Gottlieb

Liu

et al. 2009

Journal of the American Academy of Dermatology

165

104

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“…TNF-α is a cytokine that plays an important role in host defense, including immunoregulatory responses implicated in the pathogenesis of many inflammatory and autoimmune diseases [5] . In the present study, TNF-α in normal skin was predominantly localized in the basal cell layers of epidermis.…”

Section: Discussionmentioning

confidence: 99%

The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

Chen

Liu

Yue

2007

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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In order to investigate the role of TNF-and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-and ICAM-1 in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-alpha and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the increase of TNF-alpha and that of ICAM-1 in lichen planus. The expression of TNF-alpha and ICAM-1 might play an important role in the development of lichen planus.

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Expression of TNF‐α in oral lichen planus treated with fluocinolone acetonide 0.1%

Abstract: Our study exhibited that TNF-alpha may be associated with the immunopathogenesis of OLP in Thai patients and FAO 0.1% had an effect on the reduction of TNF-alpha expression.

Cited by 40 publications

References 23 publications

Steriods in the treatment of lichen planus: a review

Steriods in the treatment of lichen planus: a review

Lichen planus–like eruptions: An emerging side effect of tumor necrosis factor-α antagonists

The expression of TNF-α and ICAM-1 in lesions of lichen planus and its implication

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