Expression of thyroid transcription factor 1 in a chordoid glioma

Michotte, Alex; Veken, Jorn Van Der; Huylebrouck, Mike; Duerinck, Johnny; D’Haens, Jean; Hoorens, Anne

doi:10.1016/j.jns.2014.09.005

Cited by 12 publications

(10 citation statements)

References 10 publications

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“…Although otherwise closely replicating the established histological [6] and imaging [10] features of chordoid glioma, this case presents the novel finding of intense nuclear expression of TTF-1-thereby confirming a single similar observation recently communicated by Michotte et al [11].…”

Section: Discussionsupporting

confidence: 88%

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain

et al. 2015

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Section: Discussionsupporting

confidence: 88%

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain

et al. 2015

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“…). Furthermore, TTF‐1 expression in chordoid glioma has been reported by Michotte et al Moreover, based on the consistent expression of marker protein pS6 in pituicytoma and chordoid glioma, which is activated by TTF‐1 and the mechanistic target of rapamycin (mTOR) pathway, Hewer et al have hypothesized that chordoid glioma and pituicytoma might belong to the same tumor lineage, which originates from the base of the telencephalon . However, we believe that further molecular biology research is needed to evaluate this issue, as these two entities may exhibit differences in their histology and immunophenotype.…”

Section: Discussionmentioning

confidence: 70%

The clinicopathological features of pituicytoma and the differential diagnosis of sellar glioma

Wang

et al. 2016

Neuropathology

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Pituicytoma is rare and difficult to diagnose. This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33-65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6-month period. Imaging findings revealed tumors were in the intrasellar region (four cases), suprasellar region (four cases) and intra-suprasellar regions (three cases). The tumor diameters were 1.3-3.8 cm, and the preoperative diagnoses were pituitary adenoma, craniopharyngioma and meningioma. The tumors were solid and contained spindle or slightly chubby cells that were densely arranged with visible cleft-like or expanded sinusoid structures. The cells had vague boundaries, circular nuclei, fine chromatin, and a small nucleolus. Immunohistochemical staining of the pituicytomas revealed positive expression of thyroid transcription factor-1 (TTF-1) and S-100 protein (S-100), positive focal expression of glial GFAP;(five of 11 cases), and negative oligodendrocyte transcription factor 2 (Olig2), CD34 and neurofilament expression. The Ki67 index was 6% in one case and 1-2% in the other cases. Unlike pituicytoma, most sellar glioma cases exhibited GFAP and Olig2 expression, and negative TTF-1 expression. Third ventricle chordoid gliomas expressed TTF-1, GFAP and CD34, and were negative for Olig2. Our results indicate that pituicytoma typically involves dense arrangements of spindle or slightly chubby cells. The morphology is occasionally atypical, with ependymoma-like or meningioma-like structures, and occasionally exhibits pilomyxoid degeneration. Abundant sinusoids are characteristic of hemorrhagic tumors. The dense spindle cell arrangement is a relatively specific morphology, and staining for GFAP, TTF-1, Olig2 and CD4 may help differentiate pituicytoma from sellar glioma.

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“…Recently, several distinct CNS tumors arising from specific locations of the human brain have been shown to express TTF-1, including pituicytoma, spindle cell oncocytoma, granular cell tumor of the sellar region, and chordoid glioma of the third ventricle. [31][32][33][34] In 2015, two groups independaently reported diffuse TTF-1 expression in 4 and 7 subependymal giant cell astrocytomas. 14,15 Following these studies, we confirmed diffuse TTF-1 expression in all 24 subependymal giant cell astrocytoma specimens using two different clones of antibodies.…”

Section: Discussionmentioning

confidence: 99%

Thyroid transcription factor-1 distinguishes subependymal giant cell astrocytoma from its mimics and supports its cell origin from the progenitor cells in the medial ganglionic eminence

et al. 2017

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Subependymal giant cell astrocytoma is a benign brain tumor mostly associated with tuberous sclerosis complex. However, it may be misinterpreted as other high-grade brain tumors due to the presence of large tumor cells with conspicuous pleomorphism and occasional atypical features, such as tumor necrosis and endothelial proliferation. In this study, we first investigated thyroid transcription factor-1 (TTF-1) expression in a large series of subependymal giant cell astrocytomas and other histologic and locational mimics to validate the diagnostic utility of this marker. We then examined TTF-1 expression in non-neoplastic brain tissue to determine the cell origin of subependymal giant cell astrocytoma. Twenty-four subependymal giant cell astrocytoma specimens were subjected to tissue microarray construction. For comparison, a selection of tumors, including histologic mimics (21 gemistocytic astrocytomas and 24 gangliogliomas), tumors predominantly occurring at the ventricular system (50 ependymomas, 19 neurocytomas, and 7 subependymomas), and 134 astrocytomas (3 pleomorphic xanthoastrocytomas, 45 diffuse astrocytomas, 46 anaplastic astrocytomas, and 40 glioblastomas) were used. Immunohistochemical stain for TTF-1 was positive in all 24 subependymal giant cell astrocytomas, whereas negative in all astrocytomas, gangliogliomas, ependymomas, and subependymomas. Neurocytomas were positive for TTF-1 in 4/19 (21%) of cases using clone 8G7G3/1 and in 9/19 (47%) of cases using clone SPT24. In the three fetal brains that we examined, TTF-1 expression was seen in the medial ganglionic eminence, a transient fetal structure between the caudate nucleus and the thalami. There was no BRAF mutation identified by direct sequencing in the 20 subependymal giant cell astrocytomas that we studied. In conclusion, TTF-1 is a useful marker in distinguishing subependymal giant cell astrocytoma from its mimics. Expression of TTF-1 in the fetal medial ganglionic eminence indicates that subependymal giant cell astrocytoma may originate from the progenitor cells in this region.

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Expression of thyroid transcription factor 1 in a chordoid glioma

Cited by 12 publications

References 10 publications

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain

The clinicopathological features of pituicytoma and the differential diagnosis of sellar glioma

Thyroid transcription factor-1 distinguishes subependymal giant cell astrocytoma from its mimics and supports its cell origin from the progenitor cells in the medial ganglionic eminence

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