Expression of thiazide-sensitive Na+–Cl− cotransporter in the rat endolymphatic sac

Akiyama, Kosuke; Miyashita, Takenori; Mori, Terushige; Inamoto, Ryuhei; Mori, Nozomu

doi:10.1016/j.bbrc.2008.04.081

Cited by 20 publications

(14 citation statements)

References 31 publications

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“…The type of cells with most molecules has not been identified except only a few molecules [10, 46]. It should be stressed that Na + –K + –2Cl − cotransporter 2 (NKCC2) [56, 57, 59, 60] and thiazide-sensitive Na + –Cl − cotransporter (NCC) [55, 58], which had been previously recognized to be selectively located in kidney, are present in ES epithelial cells.…”

Section: Molecules Related To Transport Of Ion and Water In Es Epithementioning

confidence: 99%

“…Molecules related to Cl − transport have been reported to be an ion channel (cystic fibrosis transmembrane conductance regulator, CFTR) in the apical membrane [40], ion cotransporters in the apical membrane (NKCC2 and NCC) [56, 58], and ion exchangers (pendrin in the apical membrane [50], and Cl − –HCO 3 − exchanger (SLC4A2) in the basolateral membrane [49]). CFTR has been shown to be co-localized with ENaC [40].…”

Section: Ion Transport Properties In Es Epithelial Cellsmentioning

confidence: 99%

“…The presence of NCC in ES epithelial cells has been shown [58]. NCC had been accepted to have a specific localization in distal convoluted tubule of the kidney until NCC was found in ES epithelial cells.…”

Section: Regulation Of Na+ Transport In Esmentioning

confidence: 99%

“…Our recent study [87] has shown that salt-reduced diet with no administration of thiazide is an effective treatment in Meniere’s disease, and that during 2-year treatment period, salt-reduced diet induced the elevation of plasma aldosterone concentration with no change in other hormones, such as vasopressin, cortisol, and brain natriuretic peptide in patients with Meniere’s disease as the elevation of plasma aldosterone concentration has been reported in patients with hypertension [88]. The presence of NCC in the ES besides the kidney [55, 58] may propose a necessity to reconsider the indication of thiazide in Meniere’s disease.…”

Section: Suggestions For Clinical Aspects Of Meniere’s Disease From Rmentioning

confidence: 99%

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Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere’s disease

Mori

Miyashita

Inamoto

et al. 2016

Eur Arch Otorhinolaryngol

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Ion transport and its regulation in the endolymphatic sac (ES) are reviewed on the basis of recent lines of evidence. The morphological and physiological findings demonstrate that epithelial cells in the intermediate portion of the ES are more functional in ion transport than those in the other portions. Several ion channels, ion transporters, ion exchangers, and so on have been reported to be present in epithelial cells of ES intermediate portion. An imaging study has shown that mitochondria-rich cells in the ES intermediate portion have a higher activity of Na+, K+-ATPase and a higher Na+ permeability than other type of cells, implying that molecules related to Na+ transport, such as epithelial sodium channel (ENaC), Na+–K+–2Cl− cotransporter 2 (NKCC2) and thiazide-sensitive Na+–Cl− cotransporter (NCC), may be present in mitochondria-rich cells. Accumulated lines of evidence suggests that Na+ transport is most important in the ES, and that mitochondria-rich cells play crucial roles in Na+ transport in the ES. Several lines of evidence support the hypothesis that aldosterone may regulate Na+ transport in ES, resulting in endolymph volume regulation. The presence of molecules related to acid/base transport, such as H+-ATPase, Na+–H+ exchanger (NHE), pendrin (SLC26A4), Cl−–HCO3 − exchanger (SLC4A2), and carbonic anhydrase in ES epithelial cells, suggests that acid/base transport is another important one in the ES. Recent basic and clinical studies suggest that aldosterone may be involved in the effect of salt-reduced diet treatment in Meniere’s disease.

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Section: Molecules Related To Transport Of Ion and Water In Es Epithementioning

confidence: 99%

Section: Ion Transport Properties In Es Epithelial Cellsmentioning

confidence: 99%

Section: Regulation Of Na+ Transport In Esmentioning

confidence: 99%

Section: Suggestions For Clinical Aspects Of Meniere’s Disease From Rmentioning

confidence: 99%

See 2 more Smart Citations

Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere’s disease

Mori

Miyashita

Inamoto

et al. 2016

Eur Arch Otorhinolaryngol

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“…The ES epithelial cells express ion channels and cotransporters, such as ENaC, Na + -K + -2Cl-type 2 (NKCC-2) cotransporter in addition The sensory cell hair bundles (stereocilia), arranged in "W" formation, are exposed to the endolymph (scala media). Adapted from Lim [14] to SLC26A4, carbonic anhydrase, and Cl − /HCO 3 − exchanger [5,20,21].…”

Section: Endolymphatic Sacmentioning

confidence: 99%

Establishment of Cell Lines from the Human Middle and Inner Ear Epithelial Cells

Lim

Moon

2011

Advances in Experimental Medicine and Biology

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Oxygenated fixation demonstrates novel and improved ultrastructural features of the human endolymphatic sac

2013

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Expression of thiazide-sensitive Na+–Cl− cotransporter in the rat endolymphatic sac

Cited by 20 publications

References 31 publications

Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere’s disease

Ion transport its regulation in the endolymphatic sac: suggestions for clinical aspects of Meniere’s disease

Establishment of Cell Lines from the Human Middle and Inner Ear Epithelial Cells

Oxygenated fixation demonstrates novel and improved ultrastructural features of the human endolymphatic sac

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