Expression of the Proto‐Oncogene eIF4E in Inflammation of the Oral Cavity

Abstract

4E is not significantly elevated in inflammation of the oral cavity thus fulfilling one of the criteria that biomarkers require to be useful in a clinical setting.

Expression of small leucine-rich extracellular matrix proteoglycans biglycan and lumican reveals oral lichen planus malignant potential

“…Among them 6 identified proteins were unique to OSCC including ladinin 1, eukaryotic initiation factor 4A-I, cathepsin D, cofilin-1, laminin subunit beta-3 and protein S100-A9 and 3 were unique to adjacent, histologically unaltered tissues including mimecan, suprabasin and cystatin-A. These findings are in line with previous studies which showed increased expression of the protease cathepsin D [32], eukaryotic initiation factor 4A-I [35], cofilin -1 [36] and S100A9 protein [37] in OSCC which was correlated with progression and invasion of tumor cells. In addition, decreased expression of small leucine rich proteoglycan mimecan was previously reported in the oesophageal squamous cell carcinoma [38].…”

Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer

“…eIF4E is overexpressed in many epithelial cell cancers, including breast [8–12], colon [13, 14], bladder [15–19], cervix [20, 21], lung [22–24], and squamous cell carcinoma of the head and neck [25–32]. Some studies report that eIF4E is overexpressed in almost 100% of tumors of the breast, head and neck, and colon [8, 27, 32].…”

“…Benign tumors only had moderate evidence for gene amplification, while malignant tumors had a 4–15 fold level of amplification [43]. eIF4E protein levels were elevated in premalignant lesions in the larynx, but to a lesser extent than observed in HNSCC [25]. These studies suggest that progression to the malignant phenotype paralleled eIF4E gene amplification and overexpression [43].…”

The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma

“…However, when comparing MSI with LOH and p53 mutation assays, MSI is less frequent in head and neck SCC. EIF4E has been shown to be elevated in 100% of head and neck SCC [58]. Chandy et al [45] demonstrated the presence of EIF4E in 42% in surgical margins in patients with SCC.…”

“…Application of the modified FASAY identified one patient with clinically and histological normal mucosa harbouring a p53 mutation confirming a role of genetic aberrations in carcinogenesis. Others have investigated [53][54][55][56][57] microsatellite alterations and eIf4E [58] overexpression and provided a link between positive surgical margins and tumour recurrence. Microsatellites are polymorphic loci present in nuclear DNA and organellar DNA that consist of repeating units of 1-4 base pairs in length.…”