Expression of the p53 and maspin protein in primary prostate cancer: Correlation with clinical features

Machtens, S.; Serth, Jürgen; Bokemeyer, Carsten; Bathke, W.; Minssen, A.; Kollmannsberger, Christian; Hartmann, Jörg T.; Knüchel, Ruth; Kondo, Masahiko; Jonas, Udo; Kuczyk, Markus A.

doi:10.1002/1097-0215(20010920)95:5<337::aid-ijc1059>3.0.co;2-1

Cited by 106 publications

(85 citation statements)

References 11 publications

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“…Maspin is one of the serpins that have received great attention by basic researchers and pathologists during the past few years [9,5,6,11,12,14,15,16,17,18,20,21,22,23,24,25,27,28,31,35,36,37]. Since its characterization several biological properties have been attributed to maspin, including tumor suppressor and antiangiogenic activities [9,14,15,22,27,28,36,37].…”

Section: Discussionmentioning

confidence: 99%

“…Since its characterization several biological properties have been attributed to maspin, including tumor suppressor and antiangiogenic activities [9,14,15,22,27,28,36,37]. It is also considered as a suppressor of invasion, motility, proliferation, and metastatic potential of neoplastic cells [9,5,6,11,12,14,15,16,17,18,20,21,22,23,24,25,27,28,31,35,36,37]. Moreover, there are controversial data on the role of maspin as a downstream factor of p53 pathway [9,14,18,33,37,38].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover it has been proposed that maspin blocks plasminogen activator [27,28], a factor that mediates cellular invasion and migration. Despite the huge amount of data concerning the expression of maspin and its correlations with biological properties of human breast [9,14,15,22,27,28,36,37], prostate [18,27,31,35], and pancreatic carcinomas [16,17] and cell lines [9,14,15,16,17,18,22,27,28,31,35,36,37], little is know on maspin expression in other tissues.…”

Section: Introductionmentioning

confidence: 99%

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Maspin expression in normal skin and usual cutaneous carcinomas

et al. 2002

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Maspin is a serine protease inhibitor whose gene is located on 3q27. Several lines of evidence point towards its putative role as tumor suppressor gene and angiogenesis inhibitor; however, there are compelling data showing that maspin is also expressed in the nuclear compartment and might be associated with the differentiation of specific cell lineages. No systematic study of maspin expression in normal skin and usual skin carcinomas have been published so far. We semiquantitatively analyzed the distribution and immunoreactivity pattern of maspin in 14 squamous cell carcinomas (SCCs) and 16 basal cell carcinomas (BCCs) and in the adjacent normal epidermis of all cases. We also examined the correlation of maspin expression with histological type, grade, vascular invasion, perineural infiltration, and mitotic counting. Cytoplasmic expression of maspin was observed in suprabasal, prickle, and granular cell layers of normal epidermis; cells of the germinative hair matrix, Henle's and Huxley's layers, and cuticle of hair follicles; mature sebaceous cells and sweat gland's secretory cells. Nuclear expression was detected in some basal/myoepithelial cells of the sweat glands and scattered mature sebaceous cells. All SCCs but one grade IV SCC showed maspin expression, and it was correlated with the differentiation of these neoplasms. BCCs presented variable maspin expression, while metatypical carcinomas showed moderate to intense maspin expression, nodular BCCs variable contents of maspin and displayed a peculiar distribution, confined to the center of the neoplastic nodules. Two BCCs and one SCC showed maspin nuclear expression. No correlation with other clinical pathological features was observed. Our findings do not support the role of maspin as a tumor suppressor gene and suggest that this serpin is probably associated with specific lines of differentiation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maspin expression in normal skin and usual cutaneous carcinomas

et al. 2002

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“…3 Downregulation of maspin expression was observed in breast, prostate, bladder, oral, and lung cancer, and it was found to be associated with tumor progression and poor prognosis. [4][5][6][7][8][9] Experimental data showing maspin involvement in all key biological processes contributing to cancer progression provided mechanistic support for the original definition of maspin as a tumor suppressor. In fact, maspin has been found to be able to inhibit tumor cell motility, invasion, and metastasis, [10][11][12][13] to act as an inhibitor of angiogenesis 14 and as a pro-apoptotic molecule in breast and prostate cancer cells [15][16][17][18] and in endothelial cells.…”

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confidence: 87%

Maspin expression and melanoma progression: a matter of sub-cellular localization

et al. 2014

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Maspin, a member of the serpin family of protease inhibitors, is involved in key processes of cancer progression. Its biological activity seems to be cancer and compartment specific, with the protein acting either as a suppressor or as a tumor promoter in different cancer types. Characterization of maspin expression and its sub-cellular localization in melanoma is missing, hence, we aim to investigate its possible association with melanoma prognostic factors and disease progression. Nuclear and cytoplasmic maspin expression were evaluated on 60 nevi, 152 primary lesions, and 106 melanoma metastases using tissue microarrays and immunohistochemistry. The association between maspin immunoreactivity and patient's clinic-pathological features was evaluated. Multivariate logistic models and survival analyses were performed for maspin expression in primary melanomas. Nuclear maspin was detected in 8% nevi, 49% primary melanomas, and 28% metastases, whereas cytoplasmic maspin in 12% nevi, 18% primary lesions, and 9% metastases. In univariate analysis, nuclear maspin expression in primary melanomas was significantly associated with melanoma prognostic factors (nodular histotype, tumor thickness, mitotic rate, and ulceration) and disease stage, whereas cytoplasmic maspin was observed at higher frequency in thin superficial spreading melanomas, without mitosis. In multivariate analysis, nuclear maspin remained significantly associated with risk of developing a tumor prone to disease progression and, accordingly, with significantly shorter disease-free and overall survival. In this study, maspin was expressed at highest frequency in primary lesions and when expressed in the nuclei, was significantly associated with poor prognostic markers, melanoma recurrence, and worse survival. The present study suggests a tumor-suppressive effect of cytoplasmic maspin and a tumor-promoting effect of nuclear maspin, which open the discussion on its potential use in cancer therapy. Modern Pathology (2014) 27, 412-419; doi:10.1038/modpathol.2013.157; published online 13 September 2013Keywords: biomarker; maspin; melanoma; tissue microarrays Melanoma is a malignant neoplasm that originates from melanocytes and it is characterized by frequent local recurrence, early metastasis, and refractoriness to chemotherapy and biological treatment. 1 With early diagnosis and adequate surgical treatment of primary tumors (Stage I patients), the 5-year survival rate is 495%. 2 However, once melanoma has metastasized to distant sites, life expectancy dramatically declines, with 1-year survival rate of 33% for patients with Stage IV metastatic disease. 2 Primary tumor thickness, ulceration, and mitotic rate, together with the presence of lymph node and systemic metastases, are the histopathologic criteria used for melanoma staging to predict disease outcome in terms of life expectancy and survival rates. 2 However, a significant minority of melanomas contravenes these conventional parameters and displays unpredictable clinical behavior. Furthermore, lack of...

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“…[37][38][39] Loss of maspin protein expression has been observed frequently and is associated with poor prognosis in breast, prostatic and oral cancers. [40][41][42] A recent study suggested that maspin interacts with the p53 tumor suppressor pathway and may inhibit angiogenesis 43 in vitro and in vivo. These observations suggest that maspin acts as a tumor suppressor gene.…”

Section: Figurementioning

confidence: 99%

Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands

Nakashima

Uzawa

Kasamatsu

et al. 2005

Intl Journal of Cancer

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Adenoid cystic carcinoma (ACC) is one of the most common malignant tumors of the salivary glands. It tends to grow slowly but is associated with a poor prognosis compared to other malignant salivary gland tumors. To identify specific markers of ACC, we examined protein expression profiling in ACC xenograft and normal salivary glands (NSG) using fluorescent 2-dimensional differential in-gel electrophoresis (2-D-DIGE), an emerging technique for comparative proteomics, that improves the reproducibility and reliability of differential protein expression analysis between the samples. To identify the proteins, matrix-assisted laser desorption/ionization time-of-flight peptide mass fingerprinting was carried out. Using these strategies, we detected 4 upregulated proteins and 5 downregulated proteins in ACC xenograft. Maspin and stathmin were selected for further analyses. Western blotting and immunohistochemical staining showed a higher expression of these proteins in ACC xenograft and clinical ACC tissue compared to NSG. Furthermore, Expression of these proteins was correlated with the histologic grading of ACC (n 5 10). Therefore, our data indicate that maspin and stathmin may be not only useful biomarkers of ACC but also markers of biologic behavior in this tumor. ' 2005 Wiley-Liss, Inc.

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Expression of the p53 and maspin protein in primary prostate cancer: Correlation with clinical features

Cited by 106 publications

References 11 publications

Maspin expression in normal skin and usual cutaneous carcinomas

Maspin expression in normal skin and usual cutaneous carcinomas

Maspin expression and melanoma progression: a matter of sub-cellular localization

Protein expression profiling identifies maspin and stathmin as potential biomarkers of adenoid cystic carcinoma of the salivary glands

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