Expression of the MSPDBL2 antigen in a discrete subset ofPlasmodium falciparumschizonts is regulated by GDV1 but not linked to sexual commitment
Aline Freville,
Lindsay B. Stewart,
Kevin K.A. Tetteh
et al.
Abstract:ThePlasmodium falciparummerozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential relationship of MSPDBL2 to sexual commitment is examined, as variablemspdbl2transcript levels and proportions of MSPDBL2-positive mature schizonts in clinical isolates have previously correlated with levels of many sexual stage parasite gene transcripts, although not with the master regulatorap2-g. It is demonstrat… Show more
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