Expression of the microRNA-200 Family, microRNA-205, and Markers of Epithelial–Mesenchymal Transition as Predictors for Endoscopic Submucosal Dissection over Esophagectomy in Esophageal Adenocarcinoma: A Single-Center Experience

Neureiter, Daniel; Mayr, Christian; Winkelmann, Paul; Neumayer, Bettina; Klieser, E.; Wagner, Andrej; Hufnagl, Clemens; Emmanuel, Klaus; Holzinger, Josef; Koch, Oliver; Kiesslich, Tobias; Martín, Vicente

doi:10.3390/cells9020486

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…Interestingly, one study reported that epithelial-to-mesenchymal transition (EMT) is associated with the progression from early EAC to invasive EAC. The measurement of EMT markers prior to intervention may help to make the clinical decision between endoscopic submucosal dissection or esophagectomy as the preferred treatment [84]. Cytokines and chemokines are important components of the tumor microenvironment.…”

Section: Biology and Immunologymentioning

confidence: 99%

Molecular Biology and Clinical Management of Esophageal Adenocarcinoma

Li,

Hoefnagel,

Krishnadath

2023

Cancers

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Esophageal adenocarcinoma (EAC) is a highly lethal malignancy. Due to its rising incidence, EAC has become a severe health challenge in Western countries. Current treatment strategies are mainly chosen based on disease stage and clinical features, whereas the biological background is hardly considered. In this study, we performed a comprehensive review of existing studies and discussed how etiology, genetics and epigenetic characteristics, together with the tumor microenvironment, contribute to the malignant behavior and dismal prognosis of EAC. During the development of EAC, several intestinal-type proteins and signaling cascades are induced. The anti-inflammatory and immunosuppressive microenvironment is associated with poor survival. The accumulation of somatic mutations at the early phase and chromosomal structural rearrangements at relatively later time points contribute to the dynamic and heterogeneous genetic landscape of EAC. EAC is also characterized by frequent DNA methylation and dysregulation of microRNAs. We summarize the findings of dysregulations of specific cytokines, chemokines and immune cells in the tumor microenvironment and conclude that DNA methylation and microRNAs vary with each different phase of BE, LGD, HGD, early EAC and invasive EAC. Furthermore, we discuss the suitability of the currently employed therapies in the clinic and possible new therapies in the future. The development of targeted and immune therapies has been hampered by the heterogeneous genetic characteristics of EAC. In view of this, the up-to-date knowledge revealed by this work is absolutely important for future EAC studies and the discovery of new therapeutics.

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Section: Biology and Immunologymentioning

confidence: 99%

Molecular Biology and Clinical Management of Esophageal Adenocarcinoma

Li,

Hoefnagel,

Krishnadath

2023

Cancers

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“…Markers for epithelial mesenchymal transition (EMT) are of clinical relevance for a more targeted treatment 38 . The process of EMT enables cancer cells to enter the blood stream and form local and distant metastasis 39 .…”

Section: Technical Validationmentioning

confidence: 99%

“…Similarly, two of the most reported downregulated miRNAs in EAC, HGD, and/or NDB are hsa-miR-203a-3p 46 – 51 and hsa-miR-205-5p 45 – 47 , 50 – 52 . The latter miRNA (hsa-miR-205-5p) is known for targeting ZEB1 38 . In our dataset, we confirm the differential expression patterns of these miRNAs in disease tissue compared to healthy tissue (Fig.…”

Section: Technical Validationmentioning

confidence: 99%

Comprehensive RNA dataset of tissue and plasma from patients with esophageal cancer or precursor lesions

et al. 2022

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In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. Here, we performed comprehensive RNA (coding and non-coding) profiling in various samples from 17 patients diagnosed with esophageal adenocarcinoma, high-grade dysplastic or non-dysplastic Barrett’s esophagus. Per patient, a blood plasma sample, and a healthy and disease esophageal tissue sample were included. In total, this comprehensive dataset consists of 102 sequenced libraries from 51 samples. Based on this data, 119 expression profiles are available for three biotypes, including miRNA (51), mRNA (51) and circRNA (17). This unique resource allows for discovery of novel biomarkers and disease mechanisms, comparison of tissue and liquid biopsy profiles, integration of coding and non-coding RNA patterns, and can serve as a validation dataset in other RNA landscaping studies. Moreover, structural RNA differences can be identified in this dataset, including protein coding mutations, fusion genes, and circular RNAs.

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Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review

Xu¹,

Pan²,

Wang³

et al. 2021

Transl Cancer Res TCR

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Objective: To describe and discuss the progression of the non-coding RNA as biomarkers in early esophageal cancer.Background: Esophageal cancer without obvious symptoms during early stages is one of the most common cancers, the current clinical treatments offer possibilities of a cure, but the survival rates and the prognoses remain poor, it is a serious threat to human life and health. Most patients are usually diagnosed during terminal stages due to low sensitivity of esophageal cancer's early detection techniques. With the development of molecular biology, an increasing number of non-coding RNAs are found to be associated with the occurrence, development, and prognosis of esophageal cancer. Some of these have begun to be used in clinics and laboratories for diagnosis, treatment, and prognosis, with the goal of reducing mortality. Methods:The information for this paper was collected from a variety of sources, including a search of the keynote's references, a search for texts in college libraries, and discussions with experts in the field of esophageal cancer clinical treatment.Results: Non-coding RNA does play a regulatory role in the development of esophageal cancer, which can predict the occurrence or prognosis of tumors, and become a new class of tumor markers and therapeutic targets in clinical applications. Conclusions:In this review, we survey the recent developments in the incidence, diagnosis, and treatment of esophageal cancer, especially with new research progresses on non-coding RNA biomarkers in detail, and discuss its potential clinical applications.

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Expression of the microRNA-200 Family, microRNA-205, and Markers of Epithelial–Mesenchymal Transition as Predictors for Endoscopic Submucosal Dissection over Esophagectomy in Esophageal Adenocarcinoma: A Single-Center Experience

Cited by 3 publications

References 42 publications

Molecular Biology and Clinical Management of Esophageal Adenocarcinoma

Molecular Biology and Clinical Management of Esophageal Adenocarcinoma

Comprehensive RNA dataset of tissue and plasma from patients with esophageal cancer or precursor lesions

Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review

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