Expression of the maltose regulon in strains lacking the cyclic AMP receptor protein

Regulation of expression of the crp gene of Escherichia coli K-12: in vivo study

“…This result suggests that glucose exerts a slight repression of crp expression, which occurs independently of the effect of cAMP. Such a repression by glucose, which is independent of the presence of cAMP, has already been observed (8)(9)(10), suggesting that regulatory mechanisms other than the one directly involving cAMP and CAP could regulate the expression of catabolic operons.…”

Phosphoenolpyruvate:carbohydrate phosphotransferase system of bacteria.

“…Finally, the same suppressor mutations which had been found to suppress the defects that result from cya or crp mutations or both were found to suppress tight ptsH,I mutations too. These included the pleiotropic crp* mutations (8, 279, 344) as well as specific regulatory mutations that allow cAMP-CAP-independent transcription of single catabolic operons (24,121,248,335,382). Interestingly, these suppressors also included mutations that result in the constitutive expression of an operon (17,198,315,382).…”