Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa

Schlapbach, Christoph; Hänni, Tanja; Yawalkar, Nikhil; Hunger, Robert E.

doi:10.1016/j.jaad.2010.07.010

Cited by 332 publications

(364 citation statements)

References 26 publications

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“…It is widely acknowledged that Th17 cells play a prominent role in autoimmune and autoinflammatory disorders (28). Recently, it has been shown that the IL-23/Th17 pathway is overexpressed in hidradenitis suppurativa (29), and this provides a rationale for the use of biologicals interfering with the Th17 pathway, like ustekinumab (anti-IL-12/IL-23) and anakinra (IL-1Ra) (see http://clinicaltrials.gov/ct2/show/ NCT01704534?termϭhidradenitisϩsuppurativa&rankϭ11 and http://clinicaltrials.gov/ct2/show/NCT01558375?termϭhidraden itisϩsuppurativa&rankϭ12). Given the known suppressive effect of IFN-␥ on the expansion of Th17 cells (28), the absence of IFN-␥ production in affected skin (30) and circulating lymphocytes as found here suggests a role of defective Th1 responses for the overproduction of IL-17A.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Production Assays Reveal Discriminatory Immune Defects in Adults with Recurrent Infections and Noninfectious Inflammation

Oever¹,

Veerdonk²,

Joosten³

et al. 2014

Clin. Vaccine Immunol.

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Cytokine production assays have been primarily used in research settings studying novel immunodeficiencies. We sought to determine the diagnostic value of cytokine production assays in patients with recurrent and/or severe infectious diseases (IDs) without known immunodeficiencies and unclassified noninfectious inflammatory disorders (NIIDs). We retrospectively examined cytokine production in whole-blood and peripheral blood mononuclear cell samples from 157 adult patients. A cytokine production rate of <5% of that of healthy controls was considered defective. While monocyte-derived cytokine (tumor necrosis factor alpha [TNF-α], interleukin-1β [IL-1β], and IL-6) production was rarely affected, 30% of all included patients had deficient production of interferon gamma (IFN-γ), IL-17A, or IL-22. Twenty-five percent of the NIID patients displayed defective IFN-γ production, whereas IL-17A production was generally unaffected. In the group of ID patients, defective IFN-γ production was found in 19% and 14% of the patients with viral and bacterial infections, respectively, and in 38%, 24%, and 50% of patients with mycobacterial, mucocutaneous, and invasive fungal infections, respectively. Defective IL-17A and IL-22 production was mainly confined to ID patients with mucocutaneous fungal infections. In conclusion, cytokine production assays frequently detect defective Th1 responses in patients with mycobacterial or fungal infections, in contrast to patients with respiratory tract infections or isolated bacterial infections. Defective IL-17A and IL-22 production was primarily found in patients with fungal infections, while monocyte-derived cytokine production was unaffected. Thus, lymphocyte-derived cytokine production assays are helpful in the diagnostic workup of patients with recurrent infections and suspected immunodeficiencies and have the potential to reveal immune defects that might guide adjunctive immunomodulatory therapy.

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Section: Discussionmentioning

confidence: 99%

Cytokine Production Assays Reveal Discriminatory Immune Defects in Adults with Recurrent Infections and Noninfectious Inflammation

Oever¹,

Veerdonk²,

Joosten³

et al. 2014

Clin. Vaccine Immunol.

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“…La série de Moujahid et al ne comprenait que des hommes [6]. La pathogénie de la maladie de Verneuil reste inconnue mais des études récentes suggèrent que l'interleukine 12, 23 et le TNFα seraient impliqués, soutenant la théorie d'un désordre immunitaire ou inflammatoire [7]. Le diagnostic de la MV est clinique.…”

Section: Discussionunclassified

La maladie de Verneuil : à propos de 107 cas

Belhabib¹,

Krami²,

Errabih³

et al. 2013

Hegel

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RésuméLa maladie de Verneuil est une suppuration chronique fistulisante, sclérosante d'évolution cicatricielle. Son diagnostic est souvent méconnu et confondu avec une autre pathologie suppurative. Cette affection est caractérisée par une évolution longue, un traitement essentiellement chirurgical souvent en plusieurs temps avec un délai de cicatrisation long. C'est une maladie très invalidante au plan social et familial, pouvant entraîner un handicap réel pour le patient. À travers l'analyse de 107 observations de la maladie de Verneuil, nous avons étudié les caractéristiques épidémiologiques et cliniques de cette pathologie. Mots-clés

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“…Поломка -секретазы и дестабилизация Notch-пути способствуют постоянной активации TLR, внутриклеточ-ному появлению инфламмасом, а также увеличению ги-стиоцитов в клеточном инфильтрате у больных гнойным гидраденитом [3]. Стимуляция TLR вызывает продукцию значительного количества IL-23 -провоспалительного ме-диатора, продуцируемого макрофагами и участвующего в дифференцировке наивных Т клеток в Th17-лимфоциты [18], обнаруживаемые в реакционном инфильтрате кожно-го биоптата больных гнойным гидраденитом.…”

Section: патогенезunclassified

“…Степень аутоиммунного воспаления определяется количеством этих клеток в оча-ге поражения. Дифференцировка и увеличение количе-ства Th17-лимфоцитов в значительной степени зависят от выработки цитокинов IL-1, TGF-, IL-23, IL-6, IL-21, TNF- [3,4]. В свою очередь, продукция этих цитокинов осуществляется инфламмасомами -специфичными ор-ганеллами, находящимися внутри макрофагов и активи-рованными на их поверхности Toll-подобными рецептора-ми (Toll-like receptors, TLR) (рис .1).…”

Section: Introductionunclassified

Purulent Hidradenitis. Part I

Rodionov

Скрек

Соболев

et al. 2017

Vestnik dermatologii i venerologii

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Until recently, the pathogenesis of purulent hidradenitis was a little- and sporadically studied issue, which invariably created difficulties in the therapeutic treatment of this disease. Its often severe recurrency rate, high incidence and the lack of effective treatment have predetermined the urgency of the problem and raised the scientific and practical interest in this field among the scientists worldwide. Recent data indicate a significant role of damage-associated molecular patterns (DAMP) and the activation of congenital immunity, associated with Th17 lymphocytes, in the development of inflammatory disease. Likewise, the violation of the transmission of the cellular Notch signaling pathway plays an important role in the development of purulent hidradenitis.

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Expression of the IL-23/Th17 pathway in lesions of hidradenitis suppurativa

Cited by 332 publications

References 26 publications

Cytokine Production Assays Reveal Discriminatory Immune Defects in Adults with Recurrent Infections and Noninfectious Inflammation

Cytokine Production Assays Reveal Discriminatory Immune Defects in Adults with Recurrent Infections and Noninfectious Inflammation

La maladie de Verneuil : à propos de 107 cas

Purulent Hidradenitis. Part I

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