Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina

Bumsted-O'Brien, Keely; Hendrickson, Anita E.; Haverkamp, Silke; Ashery‐Padan, Ruth; Schulte, Dorothea

doi:10.1002/cne.21458

Cited by 38 publications

(28 citation statements)

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“…We do confirm a down-regulation of Meis2 and Meis1 in the central retina from HH18 onward (Heine et al, 2008), which was interpreted by Coy and Borycki (2010) as an up-regulation of Meis2 at the ciliary marginal zone. In the mouse optic primordium, Meis2 was detected only at the optic vesicle stage, was absent from the optic cup, but present again in the adult mouse retina (Toresson et al, 2000;Bumsted-O'Brien et al, 2007;Heine et al, 2008).…”

Section: Meis Gene Expression During Sensory Organ Developmentmentioning

confidence: 99%

“…In the developing nervous system, Meis genes control patterning and cell differentiation in several studied vertebrates (Ferran et al, 2007;Shim et al, 2007;Takahashi et al, 2008;Sá nchez-Guardado et al, 2011; see references therein), as well as in Drosophila and C. elegans. Expression of Meis is also associated with hematopoiesis and angiogenesis (Hisa et al, 2004;Azcoitia et al, 2005), and to morphogenesis and specification of the developing eye (Hisa et al, 2004;Bumsted-O'Brien et al, 2007), the olfactory system (Hisa et al, 2004;Oulad-Abdelghani et al, 1997;Toresson et al, 2000), and the developing inner ear (Oulad-Abdelghani et al, 1997;Zerucha and Prince, 2001;Hisa et al, 2004;Sá nchez-Guardado et al, 2011). Furthermore, Meis genes control cell fate specification along the proximal-distal axis of the developing vertebrate limb buds and Drosophila legs (Capdevila et al, 1999;Mercader et al, 1999Mercader et al, , 2000Wu and Cohen, 1999;Qin et al, 2002;Yashiro et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development

Sánchez-Guardado

Irimia

Sánchez-Arrones

et al. 2011

Developmental Dynamics

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Members of the Meis family of TALE homeobox transcription factors are involved in many processes of vertebrate development and morphogenesis, showing extremely complex transcriptional and spatiotemporal expression patterns. In this work, we performed a comprehensive study of chicken Meis genes using multiple approaches. First, we assessed whether the chicken genome contains a Meis3 ortholog or harbors only two Meis genes; we gathered several lines of evidence pointing to a specific loss of the Meis3 ortholog in an early ancestor of birds. Next, we studied the transcriptional diversity generated from chicken Meis genes through alternative splicing during development. Finally, we performed a detailed analysis of chick Meis1/ 2 expression patterns during early embryogenesis and organogenesis. We show that the expression of both Meis genes begins at the gastrulation stage in the three embryonic layers, presenting highly dynamic patterns with overlapping as well as distinct expression domains throughout development. Developmental Dynamics 240:1475-1492, 2011. V C 2011 Wiley-Liss, Inc.Key words: TALE family; alternative splicing; ectoderm; mesoderm; endoderm; central nervous system; sensory organs; visceral development; gut Accepted 17 January 2011 Developmental DynamicsABBREVIATIONS A atrium aip anterior intestinal portal as alternative splicing av allantoic vesicle ba branchial arches bd bile duct C conotruncus cl cloaca cnp caudal neural plate co coelom cp cardiac primordium D diencephalon da dorsal aorta dh dorsal horn dm dermomyotome dp dorsal pancreas du duodenum ect ectoderm ep ephiphysis end endoderm Eo-PmC extraocular pre-muscle cluster FB forebrain fg foregut fp floor plate Hn Hensen node HB hindbrain Hyp hypothalamus inf infundibulum isth isthmus l lens ltl larynx-trachea-lug bud lpm lateral plate mesoderm lp lens placode lv liver lb lung bud MB midbrain Mes mesencephalon mes mesoderm mg mid-gut mn mesonephric system mp mandibular process MRB mesencephalic-rhombencephalic boundary nep nephrotome nf neural fold np neural plate nr neural retina nt notochord oc otic cup oe oesophagus of optic furrow omv omphalomensenteric vena os optic stalk ot otocyst ov optic vesicle p prosomere p1 prosomere 1 p2 prosomere 2 p3 prosomere 3 pc pericardial cavity pe pigmented epithelium pf primitive fold pg primitive groove ph pharynx pm precardiac mesoderm POA preoptic area pp prechordal plate ps primitive streak psm primitive streak mesoderm PT pretectum Rh rhombencephalon rh rhombomere RhA1 rhombomere A1 rnp rostral neural plate Rp Rathke's pouch rp roof plate SC spinal cord scl sclerotome sm somatic mesoderm smp somatopleure som somite SP secondary prosencephalon sp segmental plate spm splanchnic mesoderm spp splanchnopleure st stomach sub.p subcephalic pocket sv sinus venosus tb tail bud td thyro-glossal duct Tel telencephalon TH thalamus Tv telencephalic vesicle V.n trigeminal ganglion V ventricle WGS whole genome shotgun zli zona limitans intrathalamica

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Section: Meis Gene Expression During Sensory Organ Developmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development

Sánchez-Guardado

Irimia

Sánchez-Arrones

et al. 2011

Developmental Dynamics

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“…One of the predicted mRNA targets regulated by miR-204 includes the transcription factor MEIS2 (49,(51)(52)(53). Previously, miR-204 downregulation and, correspondingly, MEIS2 upregulation was suggested to cause abnormal lens development in the Medaka fish (47).…”

Section: Regulation Of Sc-associated Target Expression By Pre-mir-204mentioning

confidence: 99%

Implication of the miR-184 and miR-204 Competitive RNA Network in Control of Mouse Secondary Cataract

Hoffmann

Huang

Suetsugu-Maki

et al. 2012

Mol Med

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The high recurrence rate of secondary cataract (SC) is caused by the intrinsic differentiation activity of residual lens epithelial cells after extra-capsular lens removal. The objective of this study was to identify changes in the microRNA (miRNA) expression profile during mouse SC formation and to selectively manipulate miRNA expression for potential therapeutic intervention. To model SC, mouse cataract surgery was performed and temporal changes in the miRNA expression pattern were determined by microarray analysis. To study the potential SC counterregulative effect of miRNAs, a lens capsular bag in vitro model was used. Within the first 3 wks after cataract surgery, microarray analysis demonstrated SC-associated expression pattern changes of 55 miRNAs. Of the identified miRNAs, miR-184 and miR-204 were chosen for further investigations. Manipulation of miRNA expression by the miR-184 inhibitor (antimiR-184) and the precursor miRNA for miR-204 (pre-miR-204) attenuated SC-associated expansion and migration of lens epithelial cells and signs of epithelial to mesenchymal transition such as α-smooth muscle actin expression. In addition, pre-miR-204 attenuated SC-associated expression of the transcription factor Meis homeobox 2 (MEIS2). Examination of miRNA target binding sites for miR-184 and miR-204 revealed an extensive range of predicted target mRNA sequences that were also a target to a complex network of other SC-associated miRNAs with possible opposing functions. The identification of the SC-specific miRNA expression pattern together with the observed in vitro attenuation of SC by anti-miR-184 and pre-miR-204 suggest that miR-184 and miR-204 play a significant role in the control of SC formation in mice that is most likely regulated by a complex competitive RNA network.

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“…The Meis2 gene is also expressed in the cerebral cortex and striatum in the perinatal monkey [Takahashi et al, 2008]. Meis2 transcripts are detected in the retina of the early developing mouse and chicken [Bumsted-O'Brien et al, 2007;Heine et al, 2008] and in humans MEIS2 is expressed in the retina both during development and in the adult [Bumsted-O'Brien et al, 2007].…”

Section: Introductionmentioning

confidence: 98%

Spatiotemporal Distribution of <i>PAX6</i> and <i>MEIS2</i> Expression and Total Cell Numbers in the Ganglionic Eminence in the Early Developing Human Forebrain

et al. 2010

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The development of the human neocortex is a complex and highly regulated process involving a time-related expression of many transcription factors including the homeobox genes Pax6 and Meis2. During early development, Pax6 is expressed in nuclei of radial glia cells in the neocortical proliferative zones and controls the differentiation and neurogenetic fate of these cells in the dorsal telencephalon in rodents. Animal studies on the Meis2 gene have revealed expression in the developing telencephalon and Meis2 is known to regulate the expression of Pax6 in the eye and pancreas. Because of this functional relation between Pax6 and Meis2, we studied the spatial and temporal expression of PAX6, and MEIS2 using a developmental series of human fetal brains at 7–19 postconceptional weeks with emphasis on the forebrain to investigate whether the two genes are expressed in the same regions and zones in the same time window. We demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes are expressed during early fetal brain development in humans. PAX6 mRNA and protein were located in the proliferative zones of the neocortex and in single cells in the cortical preplate at 7 fetal weeks and in the developing cortical plate from 8 or 9 to 19 fetal weeks. The expression of PAX6 expanded into the ganglionic eminence just prior to the stage at which a stereological estimation showed an exponential rise in total cell number in this area. The MEIS2 gene was also present in the proliferative zones of the human fetal neocortex and a higher expression of MEIS2 than PAX6 was observed in these areas at 9 fetal weeks. Further, MEIS2 was expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate.

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Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina

Cited by 38 publications

References 64 publications

Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development

Distinct and redundant expression and transcriptional diversity of MEIS gene paralogs during chicken development

Implication of the miR-184 and miR-204 Competitive RNA Network in Control of Mouse Secondary Cataract

Spatiotemporal Distribution of <i>PAX6</i> and <i>MEIS2</i> Expression and Total Cell Numbers in the Ganglionic Eminence in the Early Developing Human Forebrain

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