Expression of the Growth Arrest Genes (GAS and GADD) Changes during Organogenesis in the Rat Fetus

Rees, William D.; Hay, Susan M.; Fontanier-Razzaq, Nathalie C.; Antipatis, Christos; Harries, D.N.

doi:10.1093/jn/129.8.1532

Cited by 20 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the context of this study, it is noteworthy that ATF3 has a similar pattern of expression to the mRNA transcript DDIT3, which encodes a nuclear protein that is a dominant negative regulator of the transcription factors C/EBP, liver activator protein, and ATF3 (58,59). Experimentally DDIT3 has been shown to be induced by neuronal hypoxia but although expressed in normal kidney there is little known about the role of DDIT3 in renal disease (60,61). Fig.…”

Section: Figmentioning

confidence: 80%

Sequential Extracellular Matrix-focused and Baited-global Cluster Analysis of Serial Transcriptomic Profiles Identifies Candidate Modulators of Renal Tubulointerstitial Fibrosis in Murine Adriamycin-induced Nephropathy

Sadlier

Connolly

Kieran

et al. 2004

Journal of Biological Chemistry

View full text Add to dashboard Cite

Transcriptome analysis using microarray technology represents a powerful unbiased approach for delineating pathogenic mechanisms in disease. Here molecular mechanisms of renal tubulointerstitial fibrosis (TIF) were probed by monitoring changes in the renal transcriptome in a glomerular disease-dependent model of TIF (adriamycin nephropathy) using Affymetrix (mu74av2) microarray coupled with sequential primary biological function-focused and secondary "baited"-global cluster analysis of gene expression profiles. Primary cluster analysis focused on mRNAs encoding matrix proteins and modulators of matrix turnover as classified by Onto-Compare and Gene Ontology and identified both molecules and pathways already implicated in the pathogenesis of TIF (e.g. transforming growth factor ␤1-CTGF-fibronectin-1 pathway) and novel TIF-associated genes (e.g. SPARC and Matrilin-2). Specific gene expression patterns identified by primary extracellular matrix-focused cluster analysis were then used as bioinformatic bait in secondary global clustering, with which to search the renal transcriptome for novel modulators of TIF. Among the genes clustering with ECM proteins in the latter analysis were endoglin, clusterin, and gelsolin. In several notable cases (e.g. claudin-1 and meprin-1␤) the pattern of gene expression identified in adriamycin nephropathy in vivo was replicated during transdifferentiation of renal tubule epithelial cells to a fibroblast-like phenotype in vitro on exposure to transforming growth factor-␤ and epidermal growth factor suggesting a role in fibrogenesis. The further exploration of these complex gene networks should shed light on the core molecular pathways that underpin TIF in renal disease.

show abstract

Section: Figmentioning

confidence: 80%

Sequential Extracellular Matrix-focused and Baited-global Cluster Analysis of Serial Transcriptomic Profiles Identifies Candidate Modulators of Renal Tubulointerstitial Fibrosis in Murine Adriamycin-induced Nephropathy

Sadlier

Connolly

Kieran

et al. 2004

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

“…The expression of CHOP, a key regulator of ER stress (Oyadomari and Mori, 2004), was detected only during later stages of embryonic heart development in the rat fetus (Rees et al, 1999). In this study, we reasoned that enforced expression of CHOP in E14.5 myocytes expressing D2SV would sensitize D2SV-expressing cells and subsequently induce cell death.…”

Section: Mechanisms Underlying D2sv Protein Aggregationmentioning

confidence: 91%

A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway

Sun

Zhang

Wafa

et al. 2009

Journal of Cell Science

View full text Add to dashboard Cite

show abstract

“…as cells terminally differentiate (Rees et al 1999). Microarray analysis predicted reduced Gas1 expression in both hybrid classes.…”

Section: Perturbation Of Cell Cycle Regulatory Genes In the F 1 Hybridsmentioning

confidence: 98%

Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Duselis

Obergfell

Mack

et al. 2007

Reprod. Fertil. Dev.

View full text Add to dashboard Cite

Abstract.Crosses between two species of the rodent genus Peromyscus produce defects in both growth and development. The defects are pronounced in the hybrid placentas. Peromyscuys maniculatus (strain BW) females mated to P. polionotus (strain PO) males produce placentas half the size of the parental species, as well as growth-retarded embryos. In contrast, PO females mated to BW males result in defective conceptuses that display embryonic and placental overgrowth. These 'parent-of-origin'-dependent phenotypes are consistent with previous studies that demonstrated altered expression of imprinted genes and genetic linkage of the overgrowth phenotypes to imprinted domains. In the present study, we take a broader approach in assessing perturbations in hybrid placental gene expression through the use of Mus musculus cDNA microarrays. In verifying classes of genes identified in microarray screens differentially regulated during hybrid placental development, we focused on those influencing the cell cycle and extracellular matrix (ECM). Our work suggests that cell cycle regulators at the G 1 /S phase check-point are downregulated in the large hybrid placenta, whereas the small hybrid placenta is more variable. The ECM genes are typically downstream targets of cell cycle regulation and their misregulation is consistent with many of the dysmorphic phenotypes. Thus, these data suggest imbalances in proliferation and differentiation in hybrid placentation.

show abstract

Expression of the Growth Arrest Genes (GAS and GADD) Changes during Organogenesis in the Rat Fetus

Cited by 20 publications

References 39 publications

Sequential Extracellular Matrix-focused and Baited-global Cluster Analysis of Serial Transcriptomic Profiles Identifies Candidate Modulators of Renal Tubulointerstitial Fibrosis in Murine Adriamycin-induced Nephropathy

Sequential Extracellular Matrix-focused and Baited-global Cluster Analysis of Serial Transcriptomic Profiles Identifies Candidate Modulators of Renal Tubulointerstitial Fibrosis in Murine Adriamycin-induced Nephropathy

A splice variant of cyclin D2 regulates cardiomyocyte cell cycle through a novel protein aggregation pathway

Changes in cell cycle and extracellular matrix gene expression during placental development in deer mouse (Peromyscus) hybrids

Contact Info

Product

Resources

About