Expression of the genes for α-type and β-type calcitonin gene-related peptide during postnatal rat brain development

Terrado, José; Gerrikagoitia, Inmaculada; Martínez‐Millán, Luis; Pascual, Fred E.; Climent, Salvador; Muniesa, Pedro; Sarasa, Manuel

doi:10.1016/s0306-4522(97)00139-5

Cited by 20 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent in situ hybridization studies revealed sites of CGRP expression in the rat brain (Rethelyi et al, 1989;Kresse et al, 1995) and demonstrated the same expression profile for CGRP␣ and CGRP␤ in most brain areas (Amara et al, 1985;Noguchi et al, 1990;Terrado et al, 1997). The expression of CGRP mRNA is generally in good agreement with the distribution of CGRP-ir cell bodies (Kresse et al, 1995).…”

mentioning

confidence: 71%

Calcitonin gene-related peptide-containing pathways in the rat forebrain

et al. 2005

View full text Add to dashboard Cite

The present study focuses on the topographical distribution of calcitonin gene-related peptide (CGRP)-containing cell bodies and fibers and their connections and pathways in the rat forebrain. We confirm previously reported CGRP projections from the perifornical area of the hypothalamus to the lateral septum, from the posterior thalamus to the caudate putamen and cerebral cortex, and from the parabrachial nuclei to the central extended amygdala, lateral hypothalamus, and ventromedial thalamus. Despite previous descriptions of CGRP in the central nervous system, important neuroanatomical aspects of the forebrain CGRP system remained obscure, which we addressed by using brain lesion techniques combined with modern immunohistology. We first report CGRP terminal fields in the olfactory-anterior septal region and also CGRP projections from the parabrachial nuclei to the olfactory-anterior septal region, the medial prefrontal cortex, the interstitial nucleus of the anterior commissure, the nucleus of the lateral olfactory tract, the anterior amygdaloid area, the posterolateral cortical amygdaloid nucleus, and the dorsolateral part of the lateral amygdaloid nucleus. In addition, we identified a CGRP cell group in the premamillary nuclei and showed that it projects to the medial CGRP layer of the lateral septum. CGRP fibers usually join other pathways rather than forming bundles. They run along the fornix from the hypothalamus, along the supraoptic decussations or the inferior thalamic peduncle-stria terminalis pathway from the posterior thalamus, and along the superior cerebellar peduncle, thalamic fasciculus, and ansa peduncularis from the parabrachial nuclei. This description of the forebrain CGRP system will facilitate investigation of its role in higher brain functions.

show abstract

mentioning

confidence: 71%

Calcitonin gene-related peptide-containing pathways in the rat forebrain

et al. 2005

View full text Add to dashboard Cite

show abstract

“…One relevant example is calcitonin gene-related peptide (CGRP), which according to one report is expressed in the LHAjd region (Kresse et al, 1995)—more recent work suggests this is the alpha-type of CGRP because the beta-type is reportedly not expressed in the LHA (Terrado et al, 1997). In addition, CGRP-immunoreactive axons generate a dense terminal field in the LS, notably in the LSr.dl.m.d, where they form basket-like pericellular terminal structures (Risold and Swanson, 1997a), and a previous study indicates that at least some of these connections originate in the LHA (Dobolyi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Hahn

Swanson

2012

J of Comparative Neurology

View full text Add to dashboard Cite

The connections of the lateral hypothalamic area juxtadorsomedial region (LHAjd) were investigated in a series of pathway-tracing experiments involving iontophoretic co-injection of the tracers Phaseolus vulgaris-leucoagglutinin (PHA-L; for outputs) and cholera toxin B subunit (CTB; for inputs). Results revealed that the LHAjd has connections with some 318 distinct gray matter regions encompassing all four subsystems—motor, sensory, cognitive, and behavioral state—included in a basic structure–function network model of the nervous system. Integration of these subsystems is necessary for the coordination and control of emotion and behavior, and in that regard the connections of the LHAjd indicate that it may have a prominent role. Furthermore, the LHAjd connections, together with the connections of other LHA differentiations studied similarly to date, indicate a distinct topographic organization that suggests each LHA differentiation has specifically differing degrees of involvement in the control of multiple behaviors. For the LHAjd, its involvement to a high degree in the control of defensive behavior, and to a lesser degree in the control of other behaviors, including ingestive and reproductive, is suggested. Moreover, the connections of the LHAjd suggest that its possible role in the control of these behaviors may be very broad in scope because they involve the somatic, neuroendocrine, and autonomic divisions of the nervous system. In addition, we suggest that connections between LHA differentiations may provide, at the level of the hypothalamus, a neuronal substrate for the coordinated control of multiple themes in the behavioral repertoire.

show abstract

“…CGRP and its receptors are expressed in significant concentrations during postnatal animal brain development and are likely involved in central nervous system maturation . CGRP may also play a role in nervous system recovery after injury .…”

Section: Cgrp Physiology and Corresponding Clinical Recommendations Rmentioning

confidence: 99%

Recommendations on the Use of Anti‐CGRP Monoclonal Antibodies in Children and Adolescents

et al. 2018

View full text Add to dashboard Cite

Expression of the genes for α-type and β-type calcitonin gene-related peptide during postnatal rat brain development

Cited by 20 publications

References 50 publications

Calcitonin gene-related peptide-containing pathways in the rat forebrain

Calcitonin gene-related peptide-containing pathways in the rat forebrain

Connections of the lateral hypothalamic area juxtadorsomedial region in the male rat

Recommendations on the Use of Anti‐CGRP Monoclonal Antibodies in Children and Adolescents

Contact Info

Product

Resources

About