Expression of the Chemokine Receptor BLR2/EBI1 Is Specifically Transactivated by Epstein-Barr Virus Nuclear Antigen 2

The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation

“…3]. In contrast, several chemokine receptors such as BLR1/CXCR5, CXCR4, and CCR7 [4,8,9,15,34], which are thought to activate adhesion molecules on binding to their ligands, are only expressed on lymphocyte subpopulations. This combination of differentially expressed chemokines and chemokine receptors would allow selective activation of defined adhesion molecules.…”

Chemokines: signal lamps for trafficking of T and B cells for development and effector function

“…Activated T cells express CXCR3 [69,70], CXCR4 [71], CCR1 [72], CCR2 [72,73], CCR3 [70,74], CCR4 [71,74], CCR5 [70,73,75], CCR6 [76], CCR7 [77,78], and CCR8 [79][80][81] (Table 4). Activated T cells can be polarized to either T helper (Th) 1 or Th2 type cells, which demonstrate differential profiles of cytokine expression and helper functions in immune reaction.…”

“…CCR7 expression is expected on naive B cells because its ligands SLC and CK␤-11 readily attract freshly isolated human and murine B cells well [47,53,58,59]. CCR7 expression is up-regulated in activated B cells by Epstein-Barr virus (EBV) infection [77,90,91]. CCR2 is expressed on both resting and activated CD19 ϩ B cells [92].…”

Potential Therapeutic Molecular Targets for Nasopharyngeal Carcinoma

“…It was found to associate with the chromatin and nuclear matrix (32) and has been identified previously as a transcriptional regulator of the expression of cellular and EBV genes including AML-2 (RUNX3), CD21, CD23, c-MYC, EBI-1, Hes-1, LMP1, and LMP2A (19,44,51,80,85,130,152,255,278,303,304). Their mechanism of regulation is suggested by the binding of EBNA2 with cellular transcription factors RBPJ, CBF-2/AUF1 or Spi-1/PU.1 to specific response elements of each promoter (137).…”