Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors

Giantin, Mery; Vascellari, Marta; Lopparelli, Rm; Ariani, Pietro; Vercelli, A.; Morello, Emanuela; Cristofori, Patrizia; Granato, Anna; Buracco, Paolo; Dacasto, Mauro

doi:10.1016/j.rvsc.2012.07.035

Cited by 12 publications

(12 citation statements)

References 54 publications

(84 reference statements)

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“…Breeds associated with osteosarcoma include some giant breeds, such as Irish wolfhound, Great Dane, Saint Bernard, and Afghan hound. The highly conserved tumorigenesis ortholog MEN1 has been implicated in osteosarcoma [6], while four least conserved orthologs have also been implicated in this cancer type: AHR [50], CDN2KB [6], COX2 [51] and PTEN [52].…”

Section: Discussionmentioning

confidence: 99%

“…Among the most conserved tumorigenesis orthologs, lymphoma is associated with CDKN1A [53], TIAM1 [54] and PTEN [55]. Representative Orthologs from the least conserved set include BRCA1 [53], COX2 [50] and CXCR3 [56].…”

Section: Discussionmentioning

confidence: 99%

“…Three least conserved tumorigenesis orthologs implicated in this tumor type include FOXM1 [57], CCND1 [58] and AHR [50]. In contrast to osteosarcoma, which affects large dog breeds, mammary tumors ( Figure 15) tend to occur in the achondroplastic Dachshund and a number of small breeds including the Poodle, Maltese Terrier, Cocker Spaniel, Yorkshire Terrier and the Beagle.…”

Section: Discussionmentioning

confidence: 99%

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Leveraging Naked Mole Rat (Heterocephalus glaber) Comparative Genomics to Identify Canine Genes Modulating Susceptibility to Tumorigenesis and Cancer Phenotypes

Irizarry¹,

Punt²

2015

J Veterinar Sci Technol

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We utilized a comparative genomics approach to analyze a core set of tumorigenesis orthologs among human, mouse, dog and naked mole rat. The analysis identified cancer orthologs that are both conserved and divergent between dog and the cancer resistant species naked mole rat. These tumorigenesis orthologous are associated with phenotypes that modulate cancer susceptibility, cardiac development, craniofacial development, brain development, skeletal development, and immune function, to name a few. This bioinformatics approach employed a variety of literature mining tools to further uncover relationships between the tumorigenesis orthologs. Together, these results shed light on the relationship between breed formations, breed associated morphological traits and breed associated susceptibility to tumorigenesis. These findings support the use of a comparative genomic analysis between species with dramatically different disease phenotypes as a gene discovery tool. A total of 146 proteins coding SNPs were identified in these tumorigenesis orthologs representing missense variations, frame shift variations and nonsense variations. The genes identified in this study can serve as a list of candidates for subsequent laboratory and clinical study. Furthermore, the identification of SNPs impacting the primary structure of the tumorigenesis orthologs may provide clues about the basis of cancer susceptibility between dog breeds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Leveraging Naked Mole Rat (Heterocephalus glaber) Comparative Genomics to Identify Canine Genes Modulating Susceptibility to Tumorigenesis and Cancer Phenotypes

Irizarry¹,

Punt²

2015

J Veterinar Sci Technol

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“…The metabolic activation of DMBA, another model PAH, is mediated by CYP1A1, CYP1B1, and EPXH1, which are also regulated by the AhR [44]. In addition, AhR-dependent activation of oncogenes, NF-kB, pro-inflammatory cytokines (IL-8, IL-18), growth factors (vascular endothelial growth factor), c-Myc, cyclooxygenase-2, and amphiregulin plays an important role in carcinogenesis [45,46].…”

Section: Skin Cancermentioning

confidence: 99%

Endocrine-disrupting chemicals and skin manifestations

Qiang

Zouboulis

2016

Rev Endocr Metab Disord

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Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin. In addition, their effects on keratinocytes, melanocytes, sebocytes, inflammatory and immunological cells, and skin stem cells produce inflammatory and allergic skin diseases, chloracne, disorders of skin pigmentation, skin cancer, and skin aging. Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway. Further studies on EDCs and skin diseases are necessary to elucidate these mechanisms.

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“…In addition, P450s also partake in the biosynthesis of cuticular hydrocarbons, ecdysteroids, juvenile hormone, and pheromones [15,16]. In higher mammals, some of these xenobiotic metabolizing cytochrome P450 genes are established to be upregulated by the transcription factors such as the Aryl hydrocarbon receptor (AhR)/Aryl hydrocarbon receptor nuclear translocator (ARNT) and/or Nuclear factor erythroid-2 related factor-2 (Nrf2)/Kelchlike ECH-associated protein 1 (Keap 1) [17][18][19][20][21]. Interestingly, AhR/ ARNT and Nrf2/Keap 1 display a multilevel crosstalk where the latter is also a target of the former [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Understanding the Mechanisms Involved in the Regulation of Cytochrome P450 Gene Expression in Drosophila melanogaster (Diptera: Drosophilidae)

Br¹,

Simon²,

Mn³

et al. 2016

Entomol Ornithol Herpetol

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Expression of the aryl hydrocarbon receptor pathway and cyclooxygenase-2 in dog tumors

Cited by 12 publications

References 54 publications

Leveraging Naked Mole Rat (Heterocephalus glaber) Comparative Genomics to Identify Canine Genes Modulating Susceptibility to Tumorigenesis and Cancer Phenotypes

Leveraging Naked Mole Rat (Heterocephalus glaber) Comparative Genomics to Identify Canine Genes Modulating Susceptibility to Tumorigenesis and Cancer Phenotypes

Endocrine-disrupting chemicals and skin manifestations

Understanding the Mechanisms Involved in the Regulation of Cytochrome P450 Gene Expression in Drosophila melanogaster (Diptera: Drosophilidae)

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