Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis

Li, Xiaoyuan; Meng, Juan; Qiao, Xiaoming; Liu, Yafeng; Li, Feng; Zhang, Nan; Zhang, Jie; Holtappels, Gabriële; Ba, Luo; Zhou, Ping; Zheng, Yongbo; Lin, Ping; Liu, Shixi; Bachert, Claus

doi:10.1016/j.jaci.2010.02.023

Cited by 128 publications

(142 citation statements)

References 26 publications

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“…These findings were later confirmed in Chinese CRS subjects 29 , although these are characterized by different T effector cell profiles than their Caucasian counterparts 9 . In our study, CRSsNP subjects were confirmed to have increased TGF-β1 concentrations compared to CRSwNP subjects and controls (p<0.001, data not shown 31 .…”

Section: Discussionmentioning

confidence: 74%

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Tomassen

Vandeplas

Zele

et al. 2016

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 74%

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Tomassen

Vandeplas

Zele

et al. 2016

Journal of Allergy and Clinical Immunology

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“…Based on the tissue remodeling characteristics, CRS can be classified into CRS with nasal polyps (CRSwNP), which is characterized by pseudocyst formation, or without nasal polyps (CRSsNP), which consists of the excessive deposition of collagen by the nasal mucosa [3,4] (fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Transforming Growth Factor-β1 Activation and Expression in the Tissue Remodeling Involved in Chronic Rhinosinusitis

Kou

Yao

et al. 2012

ORL

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Transforming growth factor-β1 (TGF-β1) plays a key role in the tissue remodeling processes involved in chronic rhinosinusitis (CRS), with the biological functions of secreted TGF-β1 regulated by multiple proteins. Among these regulators, latency-associated peptide and latent TGF-β-binding protein inhibit TGF-β1 function, whereas different proteases and integrins activate it. Progress in understanding the factors responsible for the bioactivity and expression of TGF-β1 has revealed that the dysregulation of TGF-β1 activation and expression is closely associated with the chronic respiratory inflammatory diseases involved in CRS. This review of the regulation of TGF-β1 activation and expression provides insight into the mechanism responsible for the different CRS subtypes, which will help further the investigation of novel therapy targets for the treatment of CRS.

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“…Neutrophils were found to be the major sources of TGF-β2 in CRSsNP and non-eosinophilic CRSwNP [51]. Finally, no significant difference was observed between the concentrations of MMP-7 and MMP-9 in patients with CRSwNP and CRSsNP, both of them being significantly increased compared with controls [50].…”

Section: Chinese Crswnpmentioning

confidence: 84%

“…But, like the Caucasian one, the occurrence of tissue damages in Chinese CRS seems to be mainly guided by TGF-β. This relative low expression level of TGF classes in Chinese CRS is suspected to decrease collagen, TIMP-1/4, and forkhead box P3 (FOXP3) expression [50]. In Chinese polyp tissue, ECP levels and neutrophil number correlated positively with the severity of edema and fibrosis, respectively.…”

Section: Chinese Crswnpmentioning

confidence: 97%

Remodeling and Repair in Rhinosinusitis

Watelet

Dogné

Mullier

2015

Curr Allergy Asthma Rep

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Remodeling refers to the development of specific but potentially irreversible structural changes in tissue. Caucasian eosinophilic chronic rhinosinusitis (CRS) with polyps associated or not with cystic fibrosis was discriminated by edema from CRS without nasal polyps, characterized by extensive fibrotic fields. However, changes in epithelial and extracellular matrix structures are common findings in all types of chronic inflammatory diseases of upper airways, but rarely specific and highly variable in extend. Recent studies have shown that remodeling in CRS appears to occur in parallel, rather than purely subsequent to inflammation. Furthermore, some preferential remodeling associations can be recognized. Tremendous efforts have been put in research on coagulation factors, cytokines, growth factors, and proteases supporting all phases of upper airway remodeling. The current exploration of other CRS sub-groups and of the particular link with concomitant asthma aims to optimize the classification of CRS and its staging modes and to develop novel therapies.

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Expression of TGF, matrix metalloproteinases, and tissue inhibitors in Chinese chronic rhinosinusitis

Cited by 128 publications

References 26 publications

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers

Regulation of Transforming Growth Factor-β1 Activation and Expression in the Tissue Remodeling Involved in Chronic Rhinosinusitis

Remodeling and Repair in Rhinosinusitis

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