Expression of Surfactant Proteins in the Human Canaliculus: Evidence and Potential Insights Into the Tear Flow Dynamics

Ali, Mohammad Javed; Kumar, Neeraj; Bräuer, Lars; Paulsen, Friedrich; Schicht, Martin

doi:10.1097/iop.0000000000001158

Cited by 8 publications

(1 citation statement)

References 25 publications

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“…Surfactant proteins (SPs) regulate tear flow speed and maintain the mucosal defenses of the lacrimal drainage system against microbes, and participate in the pathological processes of infectious dacryocystitis [ 65 ]. The strong expression of SPs in the canalicular system, including SP-D, provided some new hypotheses of their functions in lacrimal drainage defenses [ 66 ].…”

Section: Sp-d In Infection Related Ocular Diseasesmentioning

confidence: 99%

Role of surfactant protein-D in ocular bacterial infection

Hou

Zhang

2022

Int Ophthalmol

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Purpose Our review explains the role of surfactant protein D (SP-D) in different kinds of bacterial infection based on its presence in different ocular surface tissues. We discuss the potential role of SP-D against invasion by pathogens, with the aim of identifying new prospects for the possible mechanism of SP-D-mediated immune processes, and the diagnosis, prognosis, or treatment of ocular bacterial infection. Methods We reviewed articles about the role of SP-D in various ocular bacterial infections or infection-related ocular diseases through PubMed, Google Scholar, and the Web of Science databases. Results SP-D acts as an important immune factor that can resemble molecules in different polymerization states and that defends against pathogen invasion. The increased SP-D production and secretion in tear fluid and the cornea after ocular bacterial infections such as Staphylococcus aureus , Pseudomonas aeruginosa keratitis, and infection-related ocular diseases, was shown to have potential anti-inflammatory effects. The mechanisms of SP-D’s action against ocular bacterial infections include presenting, aggregating, opsonizing, and phagocytizing antigens, as well as regulating anti-bacterial immunity processes, including toll-like receptor-5 (TLR-5) pathway and IL-8 effect, TLR-4 and TLR-2 pathways and other possible ways remained to be elucidated in more detail. The findings demonstrate the potential of SP-D as an important clinical diagnostic biomarker prognosis predictor, and target for ocular immunotherapy. Conclusion SP-D participates in invasion by different ocular bacteria and infection-related ocular diseases through multiple immune mechanisms. This finding provides new prospects for the diagnosis, prognosis and treatment of ocular bacterial infection.

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Section: Sp-d In Infection Related Ocular Diseasesmentioning

confidence: 99%

Role of surfactant protein-D in ocular bacterial infection

Hou

Zhang

2022

Int Ophthalmol

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Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

Foligno

Loi

Pezza

et al. 2020

The Journal of Clinical Pharma

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Since the discovery of surfactant, a large amount of knowledge has been accumulated about its biology and pharmacology. Surfactant is the cornerstone of neonatal respiratory critical care, but its proteins and phospholipids are produced in various tissues and organs, with possible roles only partially similar to that played in the alveoli. As surfactant research is focused mainly on its respiratory applications, knowledge about the possible role of surfactant in extrapulmonary disorders has never been summarized. Here we aim to comprehensively review the data about surfactant biology and pharmacology in organs other than the lung, especially focusing in the more promising surfactant extrapulmonary roles. We also review any preclinical or clinical data available about the therapeutic use of surfactant in these contexts. We offer a summary of knowledge and research/development milestones, as possible useful guidance for researchers of multidisciplinary background.

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Tear Dynamics

Ramesh

2022

Foundational Papers in Oculoplastics

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Expression of Surfactant Proteins in the Human Canaliculus: Evidence and Potential Insights Into the Tear Flow Dynamics

Abstract: This study provides a proof of principle for the presence of SPs known from lungs in the canalicular system and hypothesizes their possible functions and also their potential role in the tear flow dynamics between the ocular surface and the lacrimal drainage system.

Cited by 8 publications

References 25 publications

Role of surfactant protein-D in ocular bacterial infection

Role of surfactant protein-D in ocular bacterial infection

Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues

Tear Dynamics

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