Expression of suppressor of cytokine signaling 3 (SOCS3) and interleukin-6 (-174-G/C) polymorphism in atopic conditions

Jannat, Arooma; Khan, M. Iqbal R.; Shabbir, Maria; Badshah, Yasmin

doi:10.1371/journal.pone.0219084

Cited by 4 publications

(9 citation statements)

References 49 publications

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“…In mouse models of allergic asthma and conjunctivitis, SOCS3 overexpression has been found 60,61 . Elevated expression of SOCS3 was reported in patients with atopic disorders, including food allergy, allergic rhinitis, allergic asthma, atopic dermatitis, and allergic conjunctivitis 56 . Overexpression of SOCS3 was detected in skin lesions in atopic dermatitis patients 62,63 .…”

Section: Suppressors Of Cytokine Signalling Contribution To the Aller...mentioning

confidence: 99%

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Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases

Jafarzadeh,

Chauhan,

Nemati

et al. 2023

Clin Experimental Allergy

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Suppressor of cytokine signalling (SOCS) proteins bind to certain cytokine receptors, Janus kinases and signalling molecules to regulate signalling pathways, thus controlling immune and inflammatory responses. Dysregulated expression of various types of SOCS molecules was indicated in multiple types of allergic diseases. SOCS1, SOCS2, SOCS3, SOCS5, and cytokine‐inducible SH2 domain protein (CISH) can differentially exert anti‐allergic impacts through different mechanisms, such as suppressing Th2 cell development and activation, reducing eosinophilia, decreasing IgE production, repressing production of pro‐allergic chemokines, promoting Treg cell differentiation and activation, suppressing Th17 cell differentiation and activation, increasing anti‐allergic Th1 responses, inhibiting M2 macrophage polarization, modulating survival and development of mast cells, reducing pro‐allergic activity of keratinocytes, and suppressing pulmonary fibrosis. Although some anti‐allergic effects were attributed to SOCS3, it can perform pro‐allergic impacts through several pathways, such as promoting Th2 cell development and activation, supporting eosinophilia, boosting pro‐allergic activity of eosinophils, increasing IgE production, enhancing the expression of the pro‐allergic chemokine receptor, reducing Treg cell differentiation, increasing pro‐allergic Th9 responses, as well as supporting mucus secretion and collagen deposition. In this review, we discuss the contrasting roles of SOCS proteins in contexts of allergic disorders to provide new insights regarding the pathophysiology of these diseases and possibly explore SOCS proteins as potential therapeutic targets for alleviating allergies.

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Section: Suppressors Of Cytokine Signalling Contribution To the Aller...mentioning

confidence: 99%

“…It was proposed that females are more susceptible to atopic illnesses due to the overexpression of SOCS3 in females than males. 56 Infection with helminths has a negative correlation with allergies. Infection with Schistosoma haematobium imparted protection against atopic hypersensitivity through downregulation of SOCS3.…”

Section: Proallergic Effects Of Socs3mentioning

confidence: 99%

Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases

Jafarzadeh,

Chauhan,

Nemati

et al. 2023

Clin Experimental Allergy

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“…In immune cells, including MCs, the expression of cytokines is negatively controlled by the activity of the cytokinesuppressor-proteins (SOCS) (18)(19)(20). To understand whether SOCS protein could be involved in the different responses of primed MC to re-stimulation, we investigated the level of mRNA expression of SOCS3 and the methylation profile of SOCS3 promoter by rt-MSP, in BMMCs pre-stimulated with LPS.…”

Section: Lps Tolerance Is Partially Dependent On Histone Acetylationmentioning

confidence: 99%

LPS Guides Distinct Patterns of Training and Tolerance in Mast Cells

et al. 2022

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Mast cells (MCs) are tissue-resident, long lived innate immune cells with important effector and immunomodulatory functions. They are equipped with an eclectic variety of receptors that enable them to sense multiple stimuli and to generate specific responses according on the type, strength and duration of the stimulation. Several studies demonstrated that myeloid cells can retain immunological memory of their encounters – a process termed ‘trained immunity’ or ‘innate immune memory’. As MCs are among the one of first cells to come into contact with the external environment, it is possible that such mechanisms of innate immune memory might help shaping their phenotype and effector functions; however, studies on this aspect of MC biology are still scarce. In this manuscript, we investigated the ability of MCs primed with different stimuli to respond to a second stimulation with the same or different ligands, and determined the molecular and epigenetic drivers of these responses. Our results showed that, while the stimulation with IgE and β-glucan failed to induce either tolerant or trained phenotypes, LPS conditioning was able to induce a profound and long-lasting remodeling of the signaling pathways involved in the response against LPS or fungal pathogens. On one side, LPS induced a strong state of unresponsiveness to secondary LPS stimulation due to the impairment of the PI3K-AKT signaling pathway, which resulted in the reduced activation of NF-κB and the decreased release of TNF-α and IL-6, compared to naïve MCs. On the other side, LPS primed MCs showed an increased release of TNF-α upon fungal infection with live Candida albicans, thus suggesting a dual role of LPS in inducing both tolerance and training phenotypes depending on the secondary challenge. Interestingly, the inhibition of HDAC during LPS stimulation partially restored the response of LPS-primed MCs to a secondary challenge with LPS, but failed to revert the increased cytokine production of these cells in response to C. albicans. These data indicate that MCs, as other innate immune cells, can develop innate immune memory, and that different stimulatory environments can shape and direct MC specific responses towards the dampening or the propagation of the local inflammatory response.

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“…SOCS3 is known to cause an allergic response through its Th2 activity. 11 Single-nucleotide polymorphisms (SNPs) may be present in other gene regions, such as 5′-or 3′untranslated regions (UTRs), introns, or promoters, as well as in the exonic region. Genetic variations in the 3′-UTR can modify gene expression by miRNA binding, protein-mRNA interactions, gene expression disruption, and polyadenylation; thus, SNPs in 3′-UTRs are intriguing for researchers.…”

Section: Introductionmentioning

confidence: 99%

“…SOCS3 activity is controlled by IL‐6, so change in serum levels of IL‐6 can affect SOCS3 expression and activity. SOCS3 is known to cause an allergic response through its Th2 activity 11 …”

Section: Introductionmentioning

confidence: 99%

Lack of association between SOCS3 and SOCS7 polymorphisms and psoriasis

Özçep

Atsü

Solak

et al. 2022

Immunity Inflam & Disease

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Background: Psoriasis is a common, chronic, inflammatory skin disease that involves changes taking place as a result of activation of the immune system. Suppressor of cytokine signaling proteins (SOCS) are intracellular proteins that act as endogenous inhibitors of proinflammatory pathways triggered by various cytokines. In this study, the relationship between psoriasis disease and SOCS gene polymorphisms is investigated in relation to the pathogenesis of psoriasis to clarify the psoriasis susceptibility profile. Methods:The SOCS3 rs4969169 and SOCS7 rs3748726 polymorphisms were detected using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The study was approved by the Clinical Research Ethics Committee of Bulent Ecevit University and performed in accordance with the ethical standards established in the 1964 Declaration of Helsinki and later amendments. All participants were informed of the parameters of the study, and they signed consent forms before being included.Statistical analysis was performed using the SPSS 18.0 (SPSS Inc.) package program. Results: For the SOCS3 rs4969169 genotype frequency, the CC/CT genotypes represented 67%/33% in the patient group and 73%/27% in the control group. For the SOCS7 rs3748726 genotype frequency, the TT/TC/CC genotypes made up 89%/9%/1% in the patient group and 91%/8%/1% in the control group. Conclusion:The polymorphisms of SOCS3 rs4969169 and SOCS7 rs3748726 were found to have no effective role in the pathogenesis of psoriasis. This is the first study to investigate this topic, and further studies with larger, more ethnically diverse samples are encouraged.

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Expression of suppressor of cytokine signaling 3 (SOCS3) and interleukin-6 (-174-G/C) polymorphism in atopic conditions

Cited by 4 publications

References 49 publications

Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases

Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases

LPS Guides Distinct Patterns of Training and Tolerance in Mast Cells

Lack of association between SOCS3 and SOCS7 polymorphisms and psoriasis

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