Expression of SS-A/Ro and SS-B/La Antigens in Skin Biopsy Specimens of Patients With Photosensitive Forms of Lupus Erythematosus

Ioannides, Demetris; Golden, Brian D.; Buyon, Jill P.; Bystryn, Jean‐Claude

doi:10.1001/archderm.136.3.340

Cited by 36 publications

(15 citation statements)

References 11 publications

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“…(1) UV exposure leads to an increased synthesis and expression of Ro antigen on the surface of epidermal keratinocytes; (2) anti-Ro antibodies from the circulation bind to the antigens on the cell surface; (3) the Fc domains of the bound anti-Ro antibodies are recognized by lymphocytes, leading to keratinocyte death. This hypothesis was consistent with the following study showing that photosensitivity and titer of circulating anti-Ro/anti-La antibodies were directly correlated with the expression of Ro and La antigens in skin specimens of patients with SLE [149]. However, patients with SS and SLE with anti-Ro and/or anti-La antibodies only infrequently show photosensitivity [150].…”

Section: Pathogenic Role Of Anti-ro Antibodiessupporting

confidence: 88%

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Yoshimi

Ueda

Ozato³

et al. 2012

Clinical and Developmental Immunology

113

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Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

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Section: Pathogenic Role Of Anti-ro Antibodiessupporting

confidence: 88%

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Yoshimi

Ueda

Ozato³

et al. 2012

Clinical and Developmental Immunology

113

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“…This hypothesis was recently confirmed by Ioannides et al 57 . They showed that both photosensitivity and titre of circulating anti‐Ro/anti‐La antibodies were directly correlated with the expression of Ro/SSA and La/SSB antigens in skin specimens of patients with LE.…”

Section: Ro/ssa La/ssb and Rap/rana/sscmentioning

confidence: 57%

Antibodies targeting extractable nuclear antigens: historical development and current knowledge

et al. 2001

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“…Kawashima et al (26) found that cellular and cell surface expression of 46 kDa SSA/Ro (calreticulin) was increased in response to exposure to UVB. Photosensitivity and the presence and titers of circulating anti‐SS‐A/Ro and anti‐SS‐B/La antibodies are both directly correlated with the expression of accessible and immunoreactive SS‐A/Ro and SS‐B/La antigens in the skin specimens of patients with LE (27). How these antibodies act is uncertain.…”

Section: What Is the Mechanism For Photosensitivity?mentioning

confidence: 99%

Photosensitivity in lupus erythematosus

Scheinfeld

DeLeo

2004

Photoderm Photoimm Photomed

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The basis for photosensitivity in lupus has yet to be fully defined. It is more commonly associated with subacute and tumid lupus erythematosus than with other variants. Anti-Ro antibodies appear to relate to photosensitivity. Tumor necrosis factor alpha polymorphisms appear to be important in some variants of lupus with photosensitivity. There is no sine qua non antibody or mutation of photosensitivity in lupus. In patients with lupus, more work needs to be done to define the mechanisms of photosensitivity.

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Expression of SS-A/Ro and SS-B/La Antigens in Skin Biopsy Specimens of Patients With Photosensitive Forms of Lupus Erythematosus

Cited by 36 publications

References 11 publications

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Antibodies targeting extractable nuclear antigens: historical development and current knowledge

Photosensitivity in lupus erythematosus

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