Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: An immunohistochemical study of 86 cases

Kato, Yukio; Nagashima, Yoji; Baba, Yoshifumi; Kawano, Toshiro; Furukawa, Madoka; Kubota, Akira; Yanoma, Shunsuke; Imagawa-Ishiguro, Yukari; Satake, Kenichi; Taguchi, Takahide; Hata, Ryu‐Ichiro; Mochimatsu, Izumi; Aoki, Ichiro; Kameda, Yoichi; Inayama, Yoshiaki; Tsukuda, Mamoru

doi:10.3892/ijmm.16.2.263

Cited by 23 publications

(24 citation statements)

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“…In cancers of the head and neck including oral cancer, there are some reports that SPARC expression correlates with poor prognosis [24,25]. However, in invasive oral squamous cell carcinoma (OSCC) specimen, immunohistochemical expression of SPARC was not correlated with survival rate and clinicopathological conditions such as T stage, clinical type, differentiation, and lymph node metastasis.…”

Section: Discussionmentioning

confidence: 98%

SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition

et al. 2014

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The matricellular protein, secreted protein acidic and rich in cysteine (SPARC) is thought to be involved in cell competition. The objective of this study is to investigate the role of SPARC in cancerization of oral squamous epithelium. Clinical specimens from 57 pre- and early cancerous lesion, 66 invasive squamous cell carcinoma (SCC) and controls were immunostained with SPARC. Clinical features and SPARC expression were evaluated. Furthermore, effects of SPARC knockdown and overexpression were examined in oral cancer and keratinocyte cell lines. Leukoplakia, carcinoma in situ, and early invasive SCC had more SPARC-positive cells than normal mucous epithelium. However, there were no significant differences between leukoplakia, carcinoma in situ, and early SCC, and there were no correlations between SPARC immunoreactivity and prognosis of invasive oral SCCs. Cell proliferation was down-regulated by SPARC siRNA, and enhanced by SPARC transformed keratinocytes. But SPARC overexpression did not enhance cell migration activity. SPARC is induced by dysplastic cells in the early stage of cancerization, and may improve survival capability, but is not involved in malignancy. SPARC may act to escape from elimination by cell competition.

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Section: Discussionmentioning

confidence: 98%

SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition

et al. 2014

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“…Not surprisingly, many cancers exhibit altered SPARC expression. Several cancers including glioma, melanoma, tongue and oral, head and neck, esophageal, and breast show an increased level of SPARC, relative to that of their respective normal tissue, which correlates positively with invasion and metastasis (Chin et al, 2005;Choi et al, 2008;Framson and Sage, 2004;Kato et al, 2005;Xue et al, 2006). Conversely, loss of SPARC in colorectal cancer is correlated with a worse prognosis (Cheetham et al, 2008;Yang et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

Arnold¹,

Rivera²,

Miller³

et al. 2010

Disease Models &Amp; Mechanisms

101

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Pancreatic cancer is the fourth leading cause of cancer-related death in the USA and little improvement has been seen over the last 20 years in the 5-year survival rate, which remains at 5% (Surveillance, Epidemiology, and End Results, SEER, http://seer.cancer.gov). Historically, studies have focused on cell-autonomous behavior or the molecular biology of cancer cells. However, focus is shifting to the interaction of cancer cells with their microenvironment. In particular, desmoplasia (or stromal response) is prominent in pancreatic adenocarcinoma (Korc, 2007). Crosstalk between malignant epithelial cells and the stromal compartment can promote extracellular matrix (ECM) remodeling, angiogenesis, immune cell recruitment and metastasis (Desmouliere et al

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“…PLAU has been suggested to be implicated in enhanced cell proliferation and migration (41) and as a prognostic marker for relapse-free survival of OSCCs, together with its receptor uPAR (42). SPARC, or osteonectin, is also implicated in ECM breakdown (43) and has been reported to be associated with tumor progression and metastasis (44). This protein was previously reported in two studies from Sudan, where the use of oral snuff (toombak) is common (45,46).…”

Section: Discussionmentioning

confidence: 99%

Gene expression profile of oral squamous cell carcinomas from Sri Lankan betel quid users

Suhr

Dysvik²,

Bruland³

et al. 2007

Oncol Rep

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Abstract. Oral squamous cell carcinoma (OSCC) is one of the major health problems in Sri Lanka and the disease is associated with the habit of Betel Quid (BQ) chewing. Using 35k oligo microarrays, we analyzed the gene expression profile of 15 Sri Lankan patients diagnosed with OSCCs and pair-wised normal controls and correlated the findings with the clinicopathological data. Following the recording of the scanned array images and data analysis, results for selected candidate genes were verified using QRT-PCR. Upon analysis, a total of 263 genes [71 (27%) of unknown functions previously not reported in OSCCs and 192 (73%) of known functions] were found as differentially expressed between tumors and controls. For the genes with known functions, 66 (34%; such as COL4A1, MMP1, MMP3, PLAU, SPARC and KRT19) were previously reported in OSCC and for the remaining 126 (66%; such as CD47, APOL3, RRAGC, BPIL1 and AZGP1) this is the first report in OSCCs. Hierarchical clustering of the differentially expressed 263 genes grouped the samples into several clusters with the larger one being dominated by tumors of stage 3 and 4. Two cases (a verrucous SCC and an advanced SCC), did not cluster with any of the other samples. We found two main biological pathways (cell communication and integrin-mediated cell adhesion) and 5 gene ontology categories (transcription regulator activity, structural molecule activity, intracellular signaling, cytoskeleton and signal transduction) of relevance to the OSCCs examined. Results from the QRT-PCR verified the results from the microarray experiment. This study provides valuable information on gene expression profile of OSCCs of habitual users of BQ from Sri Lanka. Of particular interest were the list of genes of known and unknown functions and the two biological pathways that we suggest as candidate genes in oral cancers associated with BQ chewing in Southeast Asia, in particular Sri Lanka. The suggested candidate genes might be used as molecular biomarkers in the early detection of the alarming problem of OSCCs in Southeast Asia in association with BQ use. These findings provide valuable information that might help in the selection of possible biomarkers that can be used in early detection of the alarming problem of oral cancer in Southeast Asia.

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Expression of SPARC in tongue carcinoma of stage II is associated with poor prognosis: An immunohistochemical study of 86 cases

Cited by 23 publications

References 0 publications

SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition

SPARC is associated with carcinogenesis of oral squamous epithelium and consistent with cell competition

Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma

Gene expression profile of oral squamous cell carcinomas from Sri Lankan betel quid users

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