Abstract:Sox3 is expressed in the progenitor cells of the embryonic CNS and functions as a dosage‐dependent regulator of CNS development in mice and man. To further investigate the role of SOX3, we generated transgenic mice using a Sox3 genomic BAC fragment. Unexpectedly, progeny from one line (termed Sex reversed (Sr)) exhibited a markedly distorted sex ratio in favour of male offspring. Analysis of the reproductive tract in adult sex ‐reversed animals indicated that all male‐specific structures were present, indicatin… Show more
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