Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance

Zhao, Zhigang; Qing-xian, Cai; Peng, Xinsheng; Chong, Yutian; Gao, Zhi-Liang

doi:10.3748/wjg.14.607

Cited by 11 publications

(13 citation statements)

References 28 publications

(36 reference statements)

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“…Zhao et al studied the clinical significance of SOCS1 gene expression in liver tissues of HBV infected patients and confirmed the correlation between SOCS‐1 expression and fibrosis stage as well as expression of SOCS‐1 and the inflammatory grade. In contrast to our observation, this study observed no correlation between SOCS1 expression and LFTs . Likewise, in case of biliary drainage (BD) associated with acute obstructive cholangitis, downregulated expression of SOC1 has also been reported to increase regenerative response coupled with upregulation of hepatocyte growth factor (HGF) signaling.…”

Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 90%

“…In contrast to our observation, this study observed no correlation between SOCS1 expression and LFTs. 9 Likewise, in case of biliary drainage (BD) associated with acute obstructive cholangitis, downregulated expression of SOC1 has also been reported to increase regenerative response coupled with upregulation of hepatocyte growth factor (HGF) signaling. The study further verified an inverse correlation between miR-221/222 expression and SOCS1 expression serum or in liver tissue in rats.…”

Section: Discussionmentioning

confidence: 99%

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Clinical correlation of liver function tests with suppression of cytokine signaling (SOCS1) gene expression in HCV infected patients: A real‐world clinical experience

Wahid

Ain

Quraishi

et al. 2019

Journal of Medical Virology

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Hepatitis C virus (HCV) is the leading cause of chronic liver complications globally and suppressor of cytokine signaling‐1 (SOCS‐1) is a gene triggered by cytokines that activates transcription of the JAK/STAT signal transduction pathway and negatively regulates Janus kinase‐signal transducer. Several studies have shown that the expression of SOCS1 and SOCS3 genes negatively regulate the response of HCV infection to interferon therapy and interferon‐free regimens. It has been reported that liver function enzymes elevate in CHC patients but the association of SOCS1 gene expression with LFTs haven't been studied. This study recruited 114 CHC patients and 112 normal healthy participants and analyzed the correlation of SOCS1 gene expression and liver function enzymes (LFEs). Herein, we observed that the expression of SOCS1 gene had a positive correlation with LFEs.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical correlation of liver function tests with suppression of cytokine signaling (SOCS1) gene expression in HCV infected patients: A real‐world clinical experience

Wahid

Ain

Quraishi

et al. 2019

Journal of Medical Virology

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“…39 The regulatory role of SOCS1 in oxidative stressinduced apoptosis has also been investigated to determine the role of SOCS1 in inhibition of cellular apoptosis. 40 Our study investigated expression of SOCS1 before and after glucocorticoid treatment and found that increased transcription levels of SOCS1 were positively associated with the MELD score preand post-treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Complications may occur following corticosteroid treatment, such as bleeding, infections or even enhancement of HBV replication. 6,39 Although still controversial, many research studies suggest that inhibition of the inflammatory response is an important advantage of corticosteroids. Insufficient blood samples prevented us from analyzing a larger selection of genes for detection.…”

Section: Discussionmentioning

confidence: 99%

Prognoses of patients with acute-on-chronic hepatitis B liver failure are closely associated with altered SOCS1 mRNA expression and cytokine production following glucocorticoid treatment

et al. 2014

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Suppressor of cytokine signaling (SOCS) 1 plays a crucial role in the immune response and might contribute to the prognoses of liver failure treated with glucocorticoid. We recruited 47 acute-on-chronic hepatitis B liver failure (ACHBLF) patients receiving glucocorticoid treatment and 30 healthy controls to determine the potential effects of glucocorticoid on the transcriptional level of SOCS1 in peripheral blood mononuclear cells. On the third and twenty-eighth days of glucocorticoid treatment, SOCS1 expression was negatively correlated with model for end-stage liver disease (MELD) score. Interleukin-6 (IL-6) and tumor-necrosis factor-a (TNF-a) levels were statistically lower, while the SOCS1 transcription level was higher in survivors than non-survivors both in pre-and post-treatment ACHBLF patients. The methylation rate of the SOCS1 promoter in ACHBLF patients was higher than in healthy control patients as determined by methylation-specific polymerase chain reaction. The mRNA level of SOCS1 in methylated promoters was significantly lower than from patients with unmethylated SOCS1 promoters. interferon (IFN)-c-responsive and STAT1-dependent gene expression was higher in survivors and was dramatically decreased with rising expression of SOCS1 after glucocorticoid treatment. Mortality rates were significantly higher in methylated patients than for those without methylation at the end of a 90-day follow-up. Furthermore, we found that five in six surviving patients displayed demethylated SOCS1 on the twenty-eighth day after treatment, while that number was 3 in 10 in the non-survivors. These findings suggested that ACHBLF patients without SOCS1 methylation may have a favorable response to corticosteroid treatment.

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Inhibition of STAT1 methylation is involved in the resistance of hepatitis B virus to Interferon alpha

Chen

Zheng

et al. 2010

Antiviral Research

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Expression of SOCS-1 in the liver tissues of chronic hepatitis B and its clinical significance

Abstract: AIM:To study the expression of suppressor of cytokine signaling-1 (SOCS-1) in the liver tissues of chronic hepatitis B (CHB) and the clinical significance of this expression. M E

Cited by 11 publications

References 28 publications

Clinical correlation of liver function tests with suppression of cytokine signaling (SOCS1) gene expression in HCV infected patients: A real‐world clinical experience

Clinical correlation of liver function tests with suppression of cytokine signaling (SOCS1) gene expression in HCV infected patients: A real‐world clinical experience

Prognoses of patients with acute-on-chronic hepatitis B liver failure are closely associated with altered SOCS1 mRNA expression and cytokine production following glucocorticoid treatment

Inhibition of STAT1 methylation is involved in the resistance of hepatitis B virus to Interferon alpha

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