Expression of serum miR-200a, miR-200b, and miR-200c as candidate biomarkers in epithelial ovarian cancer and their association with clinicopathological features

Abstract

Our findings suggest that miR-200a, miR-200b, and miR-200c overexpressions are associated with the aggressive tumor progression and be recognized as reliable markers to predict the prognosis and survival in EOC patients.

The circulating microRNA-200 family in whole blood are potential biomarkers for high-grade serous epithelial ovarian cancer

“…The miR-200s target two E-box binding transcription factors, ZEB1 and ZEB2, which regulate E-cadherin expression and cellular polarity (7). Increased ovarian tissue expression of miR-200a and miR-200c have been associated with a reduced overall survival in EOC patients, which may be attributed to alterations in response to chemotherapeutics with high levels of miR-200s (8,9). As a result, the miR-200 family may not only be used to detect and stage EOC but may provide information regarding prognosis.…”

miR-200c: a versatile watchdog in cancer progression, EMT, and drug resistance

“…For instance, increased levels of circulating miR-200 family members in serum have been shown to be associated with serous epithelial ovarian cancer (SEOC) [131] (Table 1). High level of miR-200c in sera of ovarian [134] and esophageal cancer patients [135] is also correlated with poor prognosis. Furthermore, presence of miR200c in patients' sera as circulating miRNA has been validated as a diagnostic marker for gastric cancer [127].…”

Genetic and epigenetic heterogeneity of epithelial ovarian cancer and the clinical implications for molecular targeted therapy

“…A variety of miRNAs are associated with tumour subtype, stage, grade, therapy resistance and prognosis in ovarian cancer 84 (Table 2). Up‐regulation of miR‐205 85 and miR‐200a 86 and down‐regulation of miR‐10187 are significantly associated with a high pathological grade and advanced stage of EOC in patients. In addition, patients with lymph node metastasis show significant elevation of miR‐200c 86.…”

“…Up‐regulation of miR‐205 85 and miR‐200a 86 and down‐regulation of miR‐10187 are significantly associated with a high pathological grade and advanced stage of EOC in patients. In addition, patients with lymph node metastasis show significant elevation of miR‐200c 86. Reduced expression of miR‐34b*/c 88, hsa‐miR‐200a, hsa‐miR‐34a and hsa‐miR‐449b 89 is frequently identified in advanced‐stage tumours.…”