Expression of Serum Amyloid A in Human Ovarian Epithelial Tumors: Implication for a Role in Ovarian Tumorigenesis

Urieli-Shoval, Simcha; Finci-Yeheskel, Zvezdana; Dishon, Shira; Galinsky, Daliah; Linke, Reinhold P.; Ariel, Ilana; Levin, Mark; Ben‐Shachar, Inbar; Prus, Diana

doi:10.1369/jhc.2010.956821

Cited by 55 publications

(64 citation statements)

References 34 publications

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“…SAA expression level was already found elevated in HCC patients. (35) Moreover, cancer studies of lung cancer, (36) renal cell cancer, (37) or ovarian carcinoma (38) have implied the potential biomarker role of SAA. Obviously, it is not appropriate to use SAA as an exclusive biomarker for any specific cancer type, whereas it could coordinate with other markers for cancer surveillance.…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomic profiles indicating genetic factors may involve in hepatocellular carcinoma familial aggregation

Zhong

Ning

et al. 2012

Cancer Science

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Familial aggregation of hepatocellular carcinoma (HCC), the third leading cause of cancer death worldwide, has shown to be a common phenomenon. We investigated the association between the genetic background and HCC familial aggregation. Serum samples were collected from HCC family members and normal control family members for screening the differentially expressed protein peaks with the approach of surface-enhanced laser desorption ionization time-of-flight mass spectrometry. Potential genetically associated protein peaks were selected and further identified by matrix assisted laser desorption ionization-time of flight mass spectrometry. A panel of six protein peaks (m/z 6432. 94, 8478.35, 9381.91, 17284.67, 17418.34, and 18111.04) were speculated to reflect the genetic susceptibility of HCC familial aggregation. Three of them (m/z 6432.94, 8478.35, and 9381.91) were selected to identify as the candidate proteins. Nine identified proteins, including mostly apolipoprotein family (ApoA1, ApoA2, ApoC3, ApoE) and serum amyloid A protein (SAA), were found overexpressed in the multiple HCC cases family members. The comparative proteomic profiles have suggested that genetic factors ought to be taken into account for familial aggregation of HCC. (Cancer Sci 2012; 103: 1833-1838 H epatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers, and ranks the third cause of cancer related death in the world (9.2% of the total).(1,2) Among different geographical regions, large variation of morbidity and risk factors were observed, with the highest rate in Asian, and lowest rate in the US as well as Europe countries.(3,4) Hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, and chronic exposure to aflatoxin play crucial roles in hepatocarcinogenesis among Asian people, while fatty liver disease and high consumption of alcohol are the dominant causes among low incidence regions.(5,6) The HCC incidence rate is remarkably high in China, accounting for approximately 55% of annual new cases in the world.(7) Particularly in Guangxi province of China, an endemic area of HBV infection, the HCC mortality has risen as the first cause of malignant cancer-relative death. (8) It is well-accepted that HBV infection constitutes the main etiological factor of HCC, while the process of hepatocarcinogenesis integrates multi-stages and multi-factors, including interactions of HBV, chemical carcinogen, and genetic susceptibility.(9) In addiction, the literature conveys that the lifetime risk of developing HCC for HBV infected individuals has been estimated to be 40%, (10) implying that a wide individual discrepancy exists in the HCC susceptibility, and that environmental factors alone are insufficient to fully address the familial aggregation of HCC. (11,12) We have observed that most HCC occurs obviously in clusters by geographical distribution or by family aggregation in Guangxi, China. Family aggregation of HCC has received researchers' attention for decades. Pedigree studies are frequently carried out to val...

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Section: Discussionmentioning

confidence: 99%

Comparative proteomic profiles indicating genetic factors may involve in hepatocellular carcinoma familial aggregation

Zhong

Ning

et al. 2012

Cancer Science

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“…NOS2 has been reported to be implicated and correlated with various prostatic diseases including PCa (26). Finally, SAA1 has been found to be highly expressed in lung cancer tissue (27) and over-expressed in ovarian carcinoma tissues (28).…”

Section: Discussionmentioning

confidence: 98%

“…These results suggest that ETS-1 represses the expression of the immunity-related genes CD38 and HDAC9, while activating the expression of BCL11A, CRISP3, DMBT1, FGR, NOS2 and SAA1 in PC3 PCa cells. Besides the roles of these genes in the immune response, several have been reported to be involved in various types of cancer, including PCa (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). However, the precise roles that these genes may play in the network of cellular and molecular mechanisms of antitumor immunology according to current models is not always clear from the literature.…”

Section: Discussionmentioning

confidence: 99%

Regulation of prostate cancer immunity-related genes in PC3 prostate cancer cells by ETS-1

Shaikhibrahim¹,

Lindstrot²,

Buettner³

et al. 2011

Oncology Letters

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Abstract. Prostate cancer (PCa) is one of the most prevalent forms of cancer affecting males worldwide, and knowledge of the immune defenses involved in PCa remains incomplete. Since the identification of immunity-related genes may have enormous implications for the understanding of PCa immunology, we recently reported the identification of immunity-related genes in PCa tissues and found potential binding sites for the ETS family prototype, ETS-1, in the majority of genes identified. Therefore, as a continuation of our previous study, we investigated whether ETS-1 regulates these genes in an in vitro PCa cell line model, PC3 cells. We specifically blocked ETS-1 in PC3 cells by transfection with an ETS-1 inverse antisense expression vector or a mock control vector. We then assessed the effect of the blockade on the expression of the recently identified PCa immunity-related genes using a comprehensive oligo gene expression microarray analysis. The results showed that ETS-1 is involved in the activation or repression of the recently identified immunity-related genes in PCa. These findings provide insights into the regulation of immunity-related genes in PCa, and emphasize the importance of ETS-1 in prostate cancer immunology.

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“…In more recent studies, SAA in serum levels were found elevated in a wide range of cancers. SAA is expressed locally in colon carcinoma and also overexpression in endometrial carcinoma and ovarian tumors (49). Breast cancer is one of the most common cancers in women worldwide.…”

Section: Acute-phase Proteins As Tumorigenic Factors or Diseases Indumentioning

confidence: 99%

Characterization of Acute-Phase Proteins (Apps)

Chu¹,

Lee²

2012

Inflammatory Diseases - Immunopathology, Clinical and Pharmacological Bases

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Expression of Serum Amyloid A in Human Ovarian Epithelial Tumors: Implication for a Role in Ovarian Tumorigenesis

Cited by 55 publications

References 34 publications

Comparative proteomic profiles indicating genetic factors may involve in hepatocellular carcinoma familial aggregation

Comparative proteomic profiles indicating genetic factors may involve in hepatocellular carcinoma familial aggregation

Regulation of prostate cancer immunity-related genes in PC3 prostate cancer cells by ETS-1

Characterization of Acute-Phase Proteins (Apps)

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