Expression of SDF-1/CXCR4 and related inflammatory factors in sodium fluoride-treated hepatocytes
Rui Yang,
Hongting Shen,
Mingjun Wang
et al.
Abstract:At present, the mechanism of fluorosis-induced damage to the hepatic system is unclear. Studies have shown that excess fluoride causes some degree of damage to the liver, including inflammation. The SDF-1/CXCR4 signaling axis has been reported to have an impact on the regulation of inflammation in human cells. In this study, we investigated the role of the SDF-1/CXCR4 signaling axis and related inflammatory factors in fluorosis through in vitro experiments on human hepatic astrocytes (LX-2) cultured with sodiu… Show more
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