Expression of <scp>IFNAR</scp>1 and <scp>IFNAR</scp>2 in cattle placenta during early pregnancy

Wang, W; Liu, Rongda; Liang, Xiaofei; Zhao, Qian; Qu, Pengxiang; Yao, Kai; Jiang, Ming; Luo, Yingchun; Zhang, W; Qing, Suzhu

doi:10.1111/rda.13118

Cited by 5 publications

(7 citation statements)

References 35 publications

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“…The expression of these receptors is thought to be ubiquitous in most nucleated cells, but can be modulated. Distinct localization of IFNAR1 and IFNAR2 is found in the bovine endometrial and glandular epithelia during the estrous cycle and early pregnancy [ 26 , 27 ]. These IFNARs were expressed in bovine caruncles during early pregnancy and showed time-dependent changes [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Distinct localization of IFNAR1 and IFNAR2 is found in the bovine endometrial and glandular epithelia during the estrous cycle and early pregnancy [ 26 , 27 ]. These IFNARs were expressed in bovine caruncles during early pregnancy and showed time-dependent changes [ 27 ]. In addition, murine proinflammatory (classical) macrophages produce larger amounts of Ifnar1 than anti-inflammatory (non-classical) macrophages, and both murine classic and non-classic macrophages also produce Ifnar2, Ifngr1, and Ifngr2 [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows

Inaba

Kawahara-Miki

Shinozawa

et al. 2022

Journal of Reproduction and Development

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Although hormonal induction of parturition in cattle results in the successful delivery of healthy calves, the risk of retained fetal membrane is significantly increased. In a previous study, a combination of the long-acting glucocorticoid, triamcinolone acetonide, with a high dose of betamethasone partially normalized the placentomal gene expression during parturition; however, the incidence of retained fetal membrane remained high. This study further explored placentomal dysfunction and aimed to elucidate the mechanism of retained fetal membrane in parturition-induced cows. In this study, transcriptome analysis revealed that enhanced glucocorticoid exposure normalized the expression of a substantial fraction of genes in the cotyledons. In contrast, a significant reduction in the multiple signaling pathway activities, including interferon signaling, was found in the caruncles during induced parturition. Real-time PCR showed that the expression of interferon-tau in the caruncles, but not interferon-alpha or interferon-gamma, was significantly lower in induced parturition than spontaneous parturition. Interferon-stimulated gene expression was also significantly decreased in the caruncles during induced parturition. These results indicate that interferon signaling could be important for immunological control in placentomes during parturition. Additionally, this suggests that interferon-tau might be a pivotal ligand for interferon receptors in the caruncles. This study revealed that peripheral blood leukocytes in prepartum cows transcribed interferon-tau. Macrophage infiltration in the placentome is known to participate in the detachment of the fetal membrane from the caruncle. Thus, this study raised the possibility that immune cells migrating into the caruncles at parturition may act as a source of ligands that activate interferon signaling.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows

Inaba

Kawahara-Miki

Shinozawa

et al. 2022

Journal of Reproduction and Development

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“…We found IFNAR1 and IFNAR2 genes, associated with response to interferon-alpha biological process, in the chromosome 1 of TAB breed. These genes have been reported to be expressed in bovine placentome tissues during early pregnancy, associated with immune tolerance protection of the mother and fetus (Wang et al, 2018). Indicine cattle are well known by their rusticity, so the presence of ROH islands linked to genes associated with the immune system and health status was expected.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Analyses Reveal the Genetic Architecture and Candidate Genes of Indicine, Taurine, Synthetic Crossbreds, and Locally Adapted Cattle in Brazil

Verardo

Silva

Machado³

et al. 2021

Front. Genet.

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Cattle population history, breeding systems, and geographic subdivision may be reflected in runs of homozygosity (ROH), effective population size (Ne), and linkage disequilibrium (LD) patterns. Thus, the assessment of this information has become essential to the implementation of genomic selection on purebred and crossbred cattle breeding programs. In this way, we assessed the genotype of 19 cattle breeds raised in Brazil belonging to taurine, indicine, synthetic crossbreds, and Iberian-derived locally adapted ancestries to evaluate the overall LD decay patterns, Ne, ROH, and breed composition. We were able to obtain a general overview of the genomic architecture of cattle breeds currently raised in Brazil and other tropical countries. We found that, among the evaluated breeds, different marker densities should be used to improve the genomic prediction accuracy and power of genome-wide association studies. Breeds showing low Ne values indicate a recent inbreeding, also reflected by the occurrence of longer ROH, which demand special attention in the matting schemes to avoid extensive inbreeding. Candidate genes (e.g., ABCA7, PENK, SPP1, IFNAR1, IFNAR2, SPEF2, PRLR, LRRTM1, and LRRTM4) located in the identified ROH islands were evaluated, highlighting biological processes involved with milk production, behavior, rusticity, and fertility. Furthermore, we were successful in obtaining the breed composition regarding the taurine and indicine composition using single-nucleotide polymorphism (SNP) data. Our results were able to observe in detail the genomic backgrounds that are present in each breed and allowed to better understand the various contributions of ancestor breeds to the modern breed composition to the Brazilian cattle.

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“…IFNT prevents luteolysis by suppressing the expression of oxytocin receptor (OXTR) in the uterine luminal (LE) and superficial glandular epithelia (sGE), which abrogates the uterine luteolytic mechanism [108,112,113] (Figure 5). All type 1 interferons, including IFNT, signals through a common receptor (IFNAR) [114,115], which is a heterodimeric receptor composed of IFNAR1 and IFNAR2 subunits [116]. All endometrial cells express IFNAR, but IFNT regulation of endometrial gene expression occurs in a cell type-specific manner.…”

Section: Figure 3 Early Embryonic Development In Cattle From Ovulation To Attachmentmentioning

confidence: 99%

“…IFNs also activates non-classical signaling cascades, such as PI3K and p38 MAP kinase pathways [121]. The bovine endometrium and conceptus express the type I interferon receptor (IFNAR) [114,115], which is a heterodimeric receptor composed of IFNAR1 and IFNAR2 subunits [116]. Thus, the elongating conceptus secretes IFNT that signals through IFNAR in the endometrium and stimulates the expression of classical and non-classical interferon-stimulated genes (ISGs), that along with progesterone induced changes in endometrium, modulate uterine gene expression which is essential for establishing uterine receptivity in ruminants [98,117,119,120].…”

Section: Introductionmentioning

confidence: 99%

Uterine regulation of preimplantation embryo development in fertility-classified heifers

Moraes¹

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Infertility and subfertility represent pervasive problems in domestic animals and humans, and embryonic mortality is a major factor influencing reproductive efficiency. In cattle, the majority of embryonic loss occurs during the first month of gestation that involves the period of blastocyst formation, conceptus elongation, maternal recognition of pregnancy, implantation and beginning of placentation. Pregnancy success and embryonic mortality are affected by paternal, maternal, embryonic, and environmental factors, and the establishment and maintenance of pregnancy are a result of complex conceptus-endometrium interactions that results in adequate conceptuses (embryo/fetus and associated extraembryonic membranes) development, implantation and placentation. Our central hypothesis is that the uterus directly influences embryonic and conceptus development, and we proposed that heifers with consistently high or low fertility have distinct uterine capacity to support pregnancy. To test this hypothesis, serial embryo transfer (3-4 rounds) was used to classify heifers based on pregnancy success on day 28 as high fertile (HF; 100%), subfertile (SF; 25%), or infertile (IF; 0%). Next, a series of experiments were conducted using the fertility-classified heifers to investigate conceptus development and uterine biology in two time points: (1) day 14, to investigate conceptus development prior to the period when pregnancy induce changes are detected in the endometrium transcriptome; (2) at day 17, to evaluate conceptus-endometrial cross talk during the period of maternal recognition of pregnancy. Results from the studies conducted on day 14 supports the idea that: (1) circulating progesterone concentrations are not different among fertility-classified heifers; (2) conceptus development and survival by day 14 is not affected by fertility classification; (3) only minimal differences in endometrium transcriptome are detected among pregnant fertility-classified heifers. Collectively, these results indicated that the biological mechanisms underlying subfertility and infertility manifests between days 14 and 28, when pregnancy recognition signaling and conceptus elongation and implantation must occur for the establishment of pregnancy. Moreover, results from the subsequent experiments conducted at day 17 indicated that: (1) the mechanism of pregnancy loss in fertility-classified heifers start to manifest around the time of maternal recognition of pregnancy; (2) conceptus survival by day 17 is compromised in IF heifers; (3) conceptus development is advanced in HF than SF heifers; (4) conceptus transcriptome is directly influenced by the uterine environment; (5) dysregulated conceptus-endometrial interactions in SF heifers seems to be the major cause of pregnancy loss. Analysis of the uterine luminal fluid (ULF) from fertility classified heifers on day 17 established that: (1) ULF composition is affected by conceptus-endometrium interactions; (2) glucose concentrations in ULF are not different among fertility-classified heifers; (3) pregnancy induced changes in the metabolites found in ULF was diminished in SF heifers, and the majority of the metabolites that increased in the ULF of pregnant HF than SF heifers were associated with energy and amino acid metabolism; (4) increased abundance of proteins involved with energy metabolism, oxidative stress, amino acid metabolism, and cell proliferation and differentiation were detected in ULF of pregnant HF than SF heifers; (5) The lipid content of the ULF is altered by pregnancy and fertility classification; (6) overall concentrations prostaglandins and interferon tau were increased in the uterine lumen of pregnant HF than SF heifers, likely due to differences in conceptus size. Collectively, results from these studies supports the idea that the dysregulated conceptus-endometrium interactions in SF heifers affects the uterine luminal contents and impairs conceptus survival and elongation. Furthermore, knowledge gained from these studies enhances our understanding of the mechanisms regulating pregnancy loss in cattle and provides new information on uterine and conceptus biology during early pregnancy in ruminants.

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Expression of IFNAR1 and IFNAR2 in cattle placenta during early pregnancy

Cited by 5 publications

References 35 publications

Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows

Impaired placentomal interferon signaling as the possible cause of retained fetal membrane in parturition-induced cows

Genome-Wide Analyses Reveal the Genetic Architecture and Candidate Genes of Indicine, Taurine, Synthetic Crossbreds, and Locally Adapted Cattle in Brazil

Uterine regulation of preimplantation embryo development in fertility-classified heifers

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