Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features

Cheng, Chao; Lu, Xiaoming; Wang, Guobin; Zheng, Liduan; Shu, Xuefeng; Zhu, Shaihong; Liu, Ke; Wu, Ke; Tong, Qiang

doi:10.1111/j.1600-0463.2010.02673.x

Cited by 84 publications

(102 citation statements)

References 26 publications

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“…Subsequent studies also confirmed that elevated expressions of SATB1 in laryngeal squamous cell carcinoma and gastric cancer are significantly involved in both tumor invasion and metastasis [8][9][10]. Unfortunately, no study has reported to date on the relationship between SATB1 and colorectal carcinoma.…”

Section: Discussionmentioning

confidence: 60%

“…In recent years, a number of studies have suggested that it plays major roles in T-cell development, early erythroid differentiation, homeostasis and response to physiological stimuli [3][4][5][6]. In addition to discoveries of these physiological roles, SATB1 has recently attracted considerable attention due to its high expression in various types of malignant tumors, such as breast cancer, gastric cancer and laryngeal cancer, which suggest a crucial role in promoting tumor invasion and metastasis [7][8][9][10]. A recent study showed that the expression of SATB2, a closely related homolog of SATB1, is associated with metastasis and poor prognosis in CRC [11].…”

Section: Introductionmentioning

confidence: 99%

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Correlation of SATB1 overexpression with the progression of human rectal cancer

Wei

Yan

Zhou

et al. 2011

Int J Colorectal Dis

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Correlation of SATB1 overexpression with the progression of human rectal cancer

Wei

Yan

Zhou

et al. 2011

Int J Colorectal Dis

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“…Other groups have reaffirmed the hypothesis of SATB1 as a pivotal molecule in cancer [9,10]. Pattani et al showed that SATB1 RNA expression in breast cancer patients was significantly higher in cancerous compared to normal tissues and correlated with TNM stage and tumour grade, although it did not correlate with survival [10].…”

Section: Introductionmentioning

confidence: 86%

“…Pattani et al showed that SATB1 RNA expression in breast cancer patients was significantly higher in cancerous compared to normal tissues and correlated with TNM stage and tumour grade, although it did not correlate with survival [10]. Also, Cheng et al showed an independently significant prognostic value for SATB1 protein expression in prediction of poorer overall survival in gastric cancer [9].…”

Section: Introductionmentioning

confidence: 99%

SATB1 Protein Is Associated with a More Aggressive Phenotype of Sporadic Colorectal Cancer

Davelaar¹,

Rygiel²,

Timmer³

et al. 2013

OJPathology

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Objective: SATB1 is a genome organizer known for its role in T-cell development. With its cage-like, nuclear architecture regulates a number of genes through epigenetic modifications. Ectopic expression of SATB1 has been shown to enhance aggressive behaviour of cancer. Here, we investigated whether this putative function can also be detected in sporadic colorectal cancer. Material and Methods: SATB1 protein expression in 107 cancer samples was screened using immunohistochemistry on tissue microarrays. These stainings were evaluated with respect to clinico-pathological parameters and patient outcome. In functional assays on cell lines, association of SATB1 with tumour cell behaviour was investigated. Results: Nuclear expression of SATB1 was seen in 17.8% of the cancers. A significantly poorer disease-free survival was seen in patients positive for SATB1 expression (Log-rank test, p = 0.003). Cox regression analysis showed that SATB1 expression (p = 0.009, RR = 3.6, 95% CI = 1.4 to 9.4) was an independent predictor of disease relapse. Knockdown and ectopic expression of SATB1 in colorectal cancer cell lines lead to a corresponding decrease and increase in the migratory and invasive capacity of the respective cells. Conclusions: In colorectal cancer, nuclear expression of SATB1 correlates with a more aggressive disease. This reflects in the accompanying increased risk of disease relapse.

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“…The expression of SATB1 has been examined in esophageal adenocarcinoma and is an independent prognostic factor (20). In several types of cancer, including laryngeal squamous cell carcinoma, endometrial cancer, hepatocellular cancer and lung cancer, high expression of SATB1 promotes tumor growth and metastasis, and is a negative prognostic factor (7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). SATB1 can regulate the expression of >1,000 genes involved in the processes of DNA organization, proliferation and apoptosis (8,9).…”

Section: Introductionmentioning

confidence: 99%

High expression of special AT‑rich sequence binding protein‑1 predicts esophageal squamous cell carcinoma relapse and poor prognosis

et al. 2017

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Abstract. Previous studies of the roles of special AT-rich sequence binding protein-1 (SATB1) in the development and progression of cancer have suggested that SATB1 promotes cancer cell metastasis. The aim of the present study is to evaluate the role of SATB1 in the progression and prognosis of esophageal squamous cell carcinoma (ESCC). ESCC tissues were collected from 102 patients and SATB1 mRNA expression was measured by reverse transcription-quantitative polymerase chain reaction. The association between expression of SATB1 mRNA with clinicopathological features and prognosis was assessed, and the prognosis of ESCC was evaluated using Kaplan-Meier survival curves. In the 102 ESCC tissues, SATB1 mRNA expression correlated with the clinical tumor node metastasis stage (P<0.05), but not with any other clinicopathological features (including age, gender, tumor differentiation grade, adjuvant radio/chemotherapy, or the consumption of alcohol and use of cigarettes) (P>0.05). The disease-free survival (DFS) and overall survival (OS) of patients with high SATB1 expression was decreased compared with those with low SATB1 expression. The present study indicated that SATB1 mRNA expression was associated with the postoperative recurrent and poor prognosis in ESCC. SATB1 may be a novel marker for predicting the recurrent and worse prognosis of ESCC. IntroductionEsophageal cancer cases are distributed worldwide; its mortality rate ranks sixth among all types of cancer and it is the fourth most commonly occurring cancer in China (1,2). China is among the highest risk areas of esophageal cancer, where ~90% of cases are squamous cell carcinoma (SCC) (3). The 5-year survival rate and quality of life remain low (3). However, the molecular mechanisms underlying the initiation and progression of esophageal SCC (ESCC) remain unclear.Special AT-rich sequence binding protein-1 (SATB1), a tissue-specific nuclear matrix binding protein, was identified in 1992 (4). SATB1 is primarily expressed in thymocytes, and also the expression of SATB1 in the basal layer of the epidermis is regulated by p63 (5,6). SATB1 can regulate gene expression by folding chromatin into loop domains and tethering DNA domains to the SATB1 network structure (7,8). Under normal conditions, SATB1 is expressed at low levels in cells and tissues, but is overexpressed in a variety of malignant tumors, including laryngeal squamous cell carcinoma, endometrial cancer, hepatocellular carcinoma, rectal cancer, cutaneous malignant melanoma, gastric cancer, prostate cancer, lung cancer and cutaneous T-cell lymphoma (7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The expression of SATB1 has been examined in esophageal adenocarcinoma and is an independent prognostic factor (20). In several types of cancer, including laryngeal squamous cell carcinoma, endometrial cancer, hepatocellular cancer and lung cancer, high expression of SATB1 promotes tumor growth and metastasis, and is a negative prognostic factor (7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). SATB1 can regul...

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Expression of SATB1 and heparanase in gastric cancer and its relationship to clinicopathologic features

Cited by 84 publications

References 26 publications

Correlation of SATB1 overexpression with the progression of human rectal cancer

Correlation of SATB1 overexpression with the progression of human rectal cancer

SATB1 Protein Is Associated with a More Aggressive Phenotype of Sporadic Colorectal Cancer

High expression of special AT‑rich sequence binding protein‑1 predicts esophageal squamous cell carcinoma relapse and poor prognosis

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