Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells

Kim, Hee-Yun; Kang, Ho-Geun; Kim, Hyung-Min; Jeong, Hyun‐Ja

doi:10.1016/j.cellimm.2023.104705

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Indeed, it has been described that under certain conditions, MC display ACE2. For example, the human MC line HMC-1 reportedly expresses measurable levels of ACE2 after activation by phorbol 12-myristate 13-acetate (PMACI) [73]. Whether activated human tissue MC can display ACE2 remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Coronavirus Receptor Expression Profiles in Human Mast Cells, Basophils, and Eosinophils

Degenfeld-Schonburg,

Sadovnik,

Smiljkovic

et al. 2024

Cells

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A major problem in SARS-CoV-2-infected patients is the massive tissue inflammation in certain target organs, including the lungs. Mast cells (MC), basophils (BA), and eosinophils (EO) are key effector cells in inflammatory processes. These cells have recently been implicated in the pathogenesis of SARS-CoV-2 infections. We explored coronavirus receptor (CoV-R) expression profiles in primary human MC, BA, and EO, and in related cell lines (HMC-1, ROSA, MCPV-1, KU812, and EOL-1). As determined using flow cytometry, primary MC, BA, and EO, and their corresponding cell lines, displayed the CoV-R CD13 and CD147. Primary skin MC and BA, as well as EOL-1 cells, also displayed CD26, whereas primary EO and the MC and BA cell lines failed to express CD26. As assessed using qPCR, most cell lines expressed transcripts for CD13, CD147, and ABL2, whereas ACE2 mRNA was not detectable, and CD26 mRNA was only identified in EOL-1 cells. We also screened for drug effects on CoV-R expression. However, dexamethasone, vitamin D, and hydroxychloroquine did not exert substantial effects on the expression of CD13, CD26, or CD147 in the cells. Together, MC, BA, and EO express distinct CoV-R profiles. Whether these receptors mediate virus–cell interactions and thereby virus-induced inflammation remains unknown at present.

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Section: Discussionmentioning

confidence: 99%

Coronavirus Receptor Expression Profiles in Human Mast Cells, Basophils, and Eosinophils

Degenfeld-Schonburg,

Sadovnik,

Smiljkovic

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

“…Several molecules expressed/released by mast cells may contribute to the interaction between mast cells and SARS-CoV-2. Mast cells express the surface angiotensin converting enzyme 2 (ACE2) receptor of the renin-angiotensin system that is considered to be a candidate receptor for SARS-CoV-2 binding to cells ( 486 , 487 ). A role for histamine released by mast cells in lung inflammation associated with SARS-CoV-2 infection was proposed almost immediately after the outbreak of the COVID-19 pandemic ( 75 ).…”

Section: Mast Cells and Viral Infection With Special Reference To Sev...mentioning

confidence: 99%

Mast cell-mediated immune regulation in health and disease

Dileepan,

Raveendran,

Sharma

et al. 2023

Front. Med.

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Mast cells are important components of the immune system, and they perform pro-inflammatory as well as anti-inflammatory roles in the complex process of immune regulation in health and disease. Because of their strategic perivascular localization, sensitivity and adaptability to the microenvironment, and ability to release a variety of preformed and newly synthesized effector molecules, mast cells perform unique functions in almost all organs. Additionally, Mast cells express a wide range of surface and cytoplasmic receptors which enable them to respond to a variety of cytokines, chemicals, and pathogens. The mast cell’s role as a cellular interface between external and internal environments as well as between vasculature and tissues is critical for protection and repair. Mast cell interactions with different immune and nonimmune cells through secreted inflammatory mediators may also turn in favor of disease promoting agents. First and forefront, mast cells are well recognized for their multifaceted functions in allergic diseases. Reciprocal communication between mast cells and endothelial cells in the presence of bacterial toxins in chronic/sub-clinical infections induce persistent vascular inflammation. We have shown that mast cell proteases and histamine induce endothelial inflammatory responses that are synergistically amplified by bacterial toxins. Mast cells have been shown to exacerbate vascular changes in normal states as well as in chronic or subclinical infections, particularly among cigarette smokers. Furthermore, a potential role of mast cells in SARS-CoV-2-induced dysfunction of the capillary-alveolar interface adds to the growing understanding of mast cells in viral infections. The interaction between mast cells and microglial cells in the brain further highlights their significance in neuroinflammation. This review highlights the significant role of mast cells as the interface that acts as sensor and early responder through interactions with cells in systemic organs and the nervous system.

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Sambou Bamboo salt™ down-regulates the expression levels of angiotensin-converting enzyme 2 in activated human mast cells

Kang,

Choi,

Kim

et al. 2023

Food Sci Biotechnol

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Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2 by activating protein-1 in human mast cells

Cited by 4 publications

References 34 publications

Coronavirus Receptor Expression Profiles in Human Mast Cells, Basophils, and Eosinophils

Coronavirus Receptor Expression Profiles in Human Mast Cells, Basophils, and Eosinophils

Mast cell-mediated immune regulation in health and disease

Sambou Bamboo salt™ down-regulates the expression levels of angiotensin-converting enzyme 2 in activated human mast cells

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