Expression of Ryanodine Receptor mRNA and Sarcoplasmic Ca2+-ATPase mRNA in the Myocardium and Intracellular Reorganization of Cardiomyocytes in Dyslipidemia and during Verapamil Treatment
Abstract:In experiments on rats, atherogenic diet led to hypercholesterolemia, while addition of verapamil to the diet led to the development of hypertriglyceridemia in these animals. Dyslipidemia induced significant changes in the cardiomyocyte ultrastructure (lytic changes in myofibrils and sarcoplasmic matrix and aggravation of autophagocytosis) that were most pronounced after addition of mercazolyl alone to the diet. After 30-day atherogenic diet, we observed a decrease in the relative content of RyR2 mRNA (by 67-7… Show more
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