Expression of resistin, CXCR3, IP-10, CCR5 and MIP-1&amp;#945; in obese patients with different severity of asthma

Rojas‐Dotor, Sara; Segura-Méndez, Nora Hilda; Miyagui-Namikawa, Ken; Mondragón-González, Rafael

doi:10.4067/s0716-97602013000100002

Cited by 17 publications

(19 citation statements)

References 26 publications

(18 reference statements)

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“…This effect might be involved in the activation and infiltration of eosinophils in the airway of asthma, especially in virus induced asthma [ 38 ]. We confirmed that IP-10 negatively correlated with FEV 1 [ 18 , 35 , 39 ].…”

Section: Discussionsupporting

confidence: 75%

Selected CC and CXC chemokines in children with atopic asthma

Machura¹,

Szczepańska²,

Mazur³

et al. 2016

pdia

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IntroductionThere are only limited data on CC and CXC chemokines regulation in children with asthma.AimWe compared the serum profile of selected CC and CXC chemokines in patients with atopic asthma and healthy children.Material and methodsSerum concentration of CC chemokines RANTES, MCP-1, and CXC chemokines IP-10, MIG, IL-8, RANTES was measured using cytometric bead array in 44 children with atopic asthma and 17 healthy subjects.ResultsThe concentration of RANTES was significantly higher and the MIG level was lower in all children with asthma as compared to their control counterparts. We observed increased RANTES and decreased MIG levels also in patients with stable asthma when compared with children in the control group. The IP-10 concentration was similar between the whole asthma group and healthy controls, while significantly increased levels of this chemokine in acute asthma have been observed when compared to stable asthma. For MCP-1 and IL-8, the serum concentration was similar in all compared groups. The MIG concentration correlated positively with IP-10, IL-8, and CRP levels and negatively with the eosinophil count. A negative correlation between the IP-10 and eosinophil count and a negative correlation between FEV1 and IP-10 were found.ConclusionsAn increased serum RANTES level in children with asthma may result in enhancement of Th2 lymphocyte recruitment into the airway. A decreased expression of Th1 chemokine MIG in children with stable asthma may contribute to a diminished antagonizing effect on Th2 cytokine production and hence intensify Th2 predominance. An increased IP-10 level in children during an asthma attack suggest that this chemokine is a serological marker of disease exacerbation.

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Section: Discussionsupporting

confidence: 75%

Selected CC and CXC chemokines in children with atopic asthma

Machura¹,

Szczepańska²,

Mazur³

et al. 2016

pdia

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“…In mouse models of allergy with diet-induced metabolic syndrome, electron microscopy has shown stressed and dysfunctional mitochondria in the bronchial epithelium, leading to AHR even in the absence of allergen exposure(49). Chemokine (C-X-C motif) receptor 3 (CXCR3), involved in immune cell regulation and allergic airway inflammation(50), has also been reported to modulate diet-induced insulin resistance and visceral adipose tissue macrophage infiltration and inflammation in mice(51). As with insulin resistance, some studies have shown that the decline in lung function in some cases precedes the development of metabolic syndrome(52); future studies should try to elucidate whether this is a cause-effect relationship, or whether both are consequences of the same process (e.g.…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma

Forno

Han

Muzumdar

et al. 2015

Journal of Allergy and Clinical Immunology

144

107

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Background Obesity increases the risk of asthma and asthma severity and is a well-known risk factor for insulin resistance and the metabolic syndrome (MS) in children and adolescents. Objective We aim to examine the association among obesity, insulin sensitivity, metabolic syndrome, and lung function in U.S. adolescents with and without asthma. Methods Cross-sectional study 1,429 adolescents aged 12–17 years in the 2007–2010 National Health and Nutrition Examination Survey. Adjusted regression was used to assess the relationships among obesity, insulin sensitivity/resistance, metabolic syndrome, and lung function in children with and without asthma. Results Insulin resistance was negatively associated with FEV1 and FVC in adolescents with and without asthma, while MS was associated with lower FEV1/FVC, with a more pronounced decrease among asthmatics; these associations were driven by overweight/obese adolescents. Higher BMI was associated with a decrease in FEV1/FVC among adolescents with insulin resistance. Compared to healthy participants, adolescents with MS had a ~2% decrease in FEV1/FVC; adolescents with asthma had a ~6% decrease; and those with MS and asthma had ~10% decreased FEV1/FVC (p<0.05). Conclusion Insulin resistance and MS are associated with worsened lung function in overweight/obese adolescents. Asthma and MS synergistically decrease lung function, as do obesity and insulin resistance. These factors may contribute to the pathogenesis of asthma severity in obese patients and warrant further investigation.

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“…However, the mechanisms or modifiers (eg, age, gender and type of obesity (general vs central)) of the putative effects of obesity on asthma remain unclear. Obesity has been associated with a pro-inflammatory state in Mexicans, 55 in whom 'obese asthma' has been linked to metabolic syndrome. 56 There has been no adequate clinical trial of weight loss and asthma in Latin America.…”

Section: Diet and Obesitymentioning

confidence: 99%

Asthma in Latin America

Forno

Gogna

Cepeda

et al. 2015

Thorax

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Consistent with the diversity of Latin America, there is profound variability in asthma burden among and within countries in this region. Regional variation in asthma prevalence is likely multifactorial and due to genetics, perinatal exposures, diet, obesity, tobacco use, indoor and outdoor pollutants, psychosocial stress, and microbial or parasitic infections. Similarly, nonuniform progress in asthma management leads to regional variability in disease morbidity. Future studies of distinct asthma phenotypes should follow up well-characterized Latin American subgroups and examine risk factors that are unique or common in Latin America (e.g. stress and violence, parasitic infections and use of biomass fuels for cooking). Because most Latin American countries share the same barriers to asthma management, concerted and multifaceted public health and research efforts are needed, including approaches to curtail tobacco use, campaigns to improve asthma treatment, broadening access to care and clinical trials of non-pharmacologic interventions (e.g. replacing biomass fuels with gas or electric stoves).

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Expression of resistin, CXCR3, IP-10, CCR5 and MIP-1α in obese patients with different severity of asthma

Cited by 17 publications

References 26 publications

Selected CC and CXC chemokines in children with atopic asthma

Selected CC and CXC chemokines in children with atopic asthma

Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma

Asthma in Latin America

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