Expression of renin-angiotensin system signalling compounds in maternal protein-restricted rats: effect on renal sodium excretion and blood pressure

Mesquita, Flávia Fernandes; Gontijo, José Antônio Rocha; Bôer, Patrícia Aline

doi:10.1093/ndt/gfp505

Cited by 65 publications

(159 citation statements)

References 45 publications

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“…We also found in FR50% animals, a graded and significant increase in blood pressure from the sixth week of life while, in LP offspring, the enhanced blood pressure was observed beyond the 12th week of age. 11,12 The current study also has demonstrated a reduction of 35% in the nephron number, against a 27% reduction in the LP model. 12,22 There is evidence that insult such as maternal food restriction, alters the total number of nephrons and also causes late-onset hypertension.…”

Section: Discussionsupporting

confidence: 53%

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Fetal kidney programming by severe food restriction: Effects on structure, hormonal receptor expression and urinary sodium excretion in rats

Vaccari

Mesquita

Gontijo

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Introduction: The present study investigates, in 23-day-old and adult male rats, the effect of severe food restriction in utero on blood pressure (BP), and its association with nephron structure and function changes, angiotensin II (AT1R/ AT2R), glucocorticoid (GR) and mineralocorticoid (MR) receptor expression. Materials and methods:The daily food supply to pregnant rats was measured and one group (n=15) received normal quantity of food (NF) while the other received 50% of that (FR50%) (n=15). Kidneys were processed to AT1R, AT2R, MR, and GR immunolocalization and for western blotting analysis. The renal function was estimated by creatinine and lithium clearances in 12-week-old offspring. Results: By stereological analyses, FR50% offspring present a reduction of nephron numbers (35%) with unchanged renal volume. Expression of AT1R and AT2R was significantly decreased in FR50% while the expression of GR and MR increased in FR50%. We also verified a pronounced decrease in urinary sodium excretion accompanied by increased BP in 12-week-old FR50% offspring. Conclusion:The current data suggest that changes in renal function are conducive to excess sodium tubule reabsorption, and this might potentiate the programming of adult hypertension. It is plausible to arise in the current study an association between decreasing natriuresis, reciprocal changes in renal AngII and steroid receptors with the hypertension development found in FR50% compared with age-matched NF offspring.

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Section: Discussionsupporting

confidence: 53%

“…11,12,23,35 We cannot rule out that the decreased renal AngII receptor expression in the FR50% progeny may be simply an adaptive downregulation response that limits the fetal renal growth and post-natal sodium transport.…”

Section: Discussionmentioning

confidence: 96%

Fetal kidney programming by severe food restriction: Effects on structure, hormonal receptor expression and urinary sodium excretion in rats

Vaccari

Mesquita

Gontijo

et al. 2013

J Renin Angiotensin Aldosterone Syst

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“…Among others, maternal low-protein diet (20), 50% food restriction (21) and glucocorticoid exposure (22) are the focus of many studies because they reflect the situation of people who live in poverty. Both of them result in LBW leading the fetus to develop adult diseases, like diabetes, heart disease and hypertension.…”

Section: Maternal-fetal Environment and Adult Diseasementioning

confidence: 99%

Maternal undernutrition and the offspring kidney: from fetal to adult life

Mesquita

Gontijo

Bôer

2010

Braz J Med Biol Res

112

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“…Fractional proximal (FEP Na ) and post-proximal (FEPP Na ) sodium excretion was calculated as C Li /C Cr × 100 and C Na /C Li × 100, respectively. [15][16][17] Data obtained over time were analysed using appropriate ANOVA for repetitive measurements. Post hoc comparisons between selected means were performed by Bonferroni's contrast test when initial ANOVA indicated statistical differences between experimental groups.…”

Section: Data Presentation and Statistical Analysismentioning

confidence: 99%

Impaired dipsogenic and renal response to repetitive intracerebroventricular angiotensin II (AngII) injections in rats

Zapparoli

Figueiredo

Bôer

et al. 2011

J Renin Angiotensin Aldosterone Syst

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The role of the central nervous system (CNS) in the control of blood pressure and hydrosaline homeostasis has been demonstrated by several studies. While circulating angiotensin II (AngII) tends to retain sodium by a direct renal action as well as through aldosterone release, stimulation of brain AngII receptors has been reported to induce natriuresis. Repetitive intracerebroventricular AngII injection was recently demonstrated to be capable of leading to desensitisation of the dipsogenic effect of AngII stimuli. The aim of the current study was to investigate a possible central desensitisation to AngII stimuli by observing the effects of a low-concentration solution of AngII on the dipsogenic and natriuretic mechanisms in conscious rats, compared with appropriate age-matched 0.15 M NaCl-injected subjects, as evaluated by lithium clearance. The present report confirmed earlier reports on the potent natriuretic and dipsogenic effects of central AngII receptor stimulation. Natriuresis is mediated by a decrease in sodium reabsorption in the proximal and post-proximal tubule segments of the nephron. The current findings lend further support to the idea that AngII, in the CNS, is instrumental in the regulation of body fluid homeostasis. The magnitude of the dipsogenic and renal response to AngII was significantly decreased by repetitive stimulus.

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Expression of renin-angiotensin system signalling compounds in maternal protein-restricted rats: effect on renal sodium excretion and blood pressure

Abstract: The current data led us to hypothesize that foetal undernutrition could be associated with decreased kidney expression of AT(R) resulting in the inability of renal tubules to handle the hydro-electrolyte balance, consequently causing arterial hypertension.

Cited by 65 publications

References 45 publications

Fetal kidney programming by severe food restriction: Effects on structure, hormonal receptor expression and urinary sodium excretion in rats

Fetal kidney programming by severe food restriction: Effects on structure, hormonal receptor expression and urinary sodium excretion in rats

Maternal undernutrition and the offspring kidney: from fetal to adult life

Impaired dipsogenic and renal response to repetitive intracerebroventricular angiotensin II (AngII) injections in rats

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