Expression of receptors for advanced glycosylated end-products in renal disease

Abel, Marcus Patrick; Ritthaler, U.; Zhang, Y.; Deng, Yulin; Schmidt, Ann Marie; Greten, J; Sernau, T.; Wahl, Patricia R.; Andrássy, K.; Ritz, Eberhard; Waldherr, Rüdiger; Stern, David M.; Nawroth, Peter P.

doi:10.1093/ndt/10.9.1662

Cited by 23 publications

(1 citation statement)

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“…RAGE is upregulated wherever its ligands accumulate, and ligand binding with RAGE results in rapid and sustained cellular activation and gene transcription [14,16,17]. Its involvement in inflammation has been suggested by many studies, and it is upregulated in most inflammatory lesions studied to date [17][18][19][20][21][22][23][24][25]. Soluble RAGE (sRAGE), which is a truncated form of the receptor spanning the extracellular ligand-binding domain, and endogenous secreted RAGE (esRAGE) generated by alternative splicing, competes with full-length RAGE for ligand binding.…”

Section: Introductionmentioning

confidence: 99%

A Potential Role for the Receptor for Advanced Glycation End-Products (RAGE) in the Development of Secondhand Smoke-Induced Chronic Sinusitis

Robin,

Trudeau,

Robbins

et al. 2024

CIMB

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Chronic sinusitis (CS) is characterized by sinonasal inflammation, mucus overproduction, and edematous mucosal tissue. CS impacts one in seven adults and estimates suggest up to 15% of the general U.S. population may be affected. This research sought to assess a potential role for receptors for advanced glycation end-products (RAGE), an inflammatory receptor expressed in tissues exposed to secondhand smoke (SHS). Human sinus tissue sections were stained for RAGE and S100s, common RAGE ligands. Wild-type mice and mice that over-express RAGE in sinonasal epithelium (RAGE TG) were maintained in room air (RA) or exposed to secondhand smoke (SHS) via a nose-only delivery system five days a week for 6 weeks. Mouse sections were stained for RAGE and tissue lysates were assayed for cleaved caspase 3, cytokines, or matrix metalloproteases. We discovered increased RAGE expression in sinus tissue following SHS exposure and in sinuses from RAGE TG mice in the absence of SHS. Cleaved caspase-3, cytokines (IL-1β, IL-3, and TNF-α), and MMPs (-9 and -13) were induced by SHS and in tissues from RAGE TG mice. These results expand the inflammatory role of RAGE signaling, a key axis in disease progression observed in smokers. In this relatively unexplored area, enhanced understanding of RAGE signaling during voluntary and involuntary smoking may help to elucidate potential therapeutic targets that may attenuate the progression of smoke-related CS.

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Section: Introductionmentioning

confidence: 99%

A Potential Role for the Receptor for Advanced Glycation End-Products (RAGE) in the Development of Secondhand Smoke-Induced Chronic Sinusitis

Robin,

Trudeau,

Robbins

et al. 2024

CIMB

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Non-enzymatic glycation and oxidative stress in chronic disease and diabetes mellitus

Nawroth

Bierhaus²,

Vogel³

et al. 1999

Med Klin

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Knowledge of the basis molecular mechanisms allows to understand the interplay of different inducers such as redicals, cytokines, AGE-proteins and amyloid-beta-peptids and to define oxidative stress as a "common endpoint" of cell dysfunction. With respect to therapeutic options it is now possible not only to optimize blood glycemic control, but also to design drugs such as AGE-inhibitors and AGE-"cross-link" breakers. In addition patients with chronic disease associated with increased oxidative stress ay benefit from an antioxidant rich (and AGE protein poor?) nutrition.

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Receptors for Advanced Glycosylation Endproducts in Human Brain: Role in Brain Homeostasis

Li¹,

Dickson

Hof

et al. 1998

Mol Med

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The selective presence of AGE-binding proteins in pyramidal neurons and glial cells and their roles in degrading AGE-modified protein in glial cells suggest that the human brain has a mechanism(s) to clear AGE-modified proteins. Without this capacity, accumulation of AGEs extracellularly could stimulate glial cells to produce the major inflammatory cytokine GM-CSF, which has been shown to be capable of up-regulating AGE-R3. It remains to be determined whether AGE-binding proteins could be aberrant or down-regulated under certain pathological conditions, resulting in an insidious inflammatory state of the CNS in some aging humans.

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Expression of receptors for advanced glycosylated end-products in renal disease

Cited by 23 publications

References 0 publications

A Potential Role for the Receptor for Advanced Glycation End-Products (RAGE) in the Development of Secondhand Smoke-Induced Chronic Sinusitis

A Potential Role for the Receptor for Advanced Glycation End-Products (RAGE) in the Development of Secondhand Smoke-Induced Chronic Sinusitis

Non-enzymatic glycation and oxidative stress in chronic disease and diabetes mellitus

Receptors for Advanced Glycosylation Endproducts in Human Brain: Role in Brain Homeostasis

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