Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

Tsukasaki, Masayuki; Yamada, Atsushi; Suzuki, Daisuke; Aizawa, Ryo; Miyazono, Agasa; Miyamoto, Yukio; Suzawa, Tetsuo; Miki, Takami; Yoshimura, Kenichi; Morimura, Naoko; Yamamoto, Masahide; Kamijo, Ryutaro

doi:10.1016/j.bbrc.2011.06.048

Cited by 22 publications

(19 citation statements)

References 26 publications

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“…Although Tsukasaki et al . 11 hypothesized that putative VDRE can be detected by a transcriptional factor search program ( alibaba ) and are located upstream of the transcriptional starting site of the Npnt gene (− 133 to − 112 and − 663 to − 642), no evidence of VDRE for the Npnt gene has been detected yet (data not shown).…”

Section: Resultsmentioning

confidence: 99%

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Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D₃

et al. 2016

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The extracellular matrix protein nephronectin (Npnt), also called POEM, is considered to play critical roles as an adhesion molecule in development and functions of various tissues, such as the kidneys, liver, and bone. In the present study, we examined the molecular mechanism of Npnt gene expression and found that vitamin D3 (1α,25‐dihydroxyvitamin D3,VD3) strongly enhanced Npnt mRNA expression in MC3T3‐E1 cells from a mouse osteoblastic cell line. The VD3‐induced increase in Npnt expression is both time‐ and dose‐dependent and is mediated by the vitamin D receptor (VDR).

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Section: Resultsmentioning

confidence: 99%

“…In our previous studies, we found that Npnt expression is downregulated by cytokines, such as TGF‐β, TNFα, and oncostatin M, via MAPK, JAK/STAT, and NF‐κβ pathways in MC3T3‐E1 cells 10, 11, 12. The present study clearly shows that VD 3 upregulates the expression of Npnt in both a time‐ and dose‐dependent manner via the VDR.…”

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confidence: 94%

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D₃

et al. 2016

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“…TNF-a also works to enhance the expression of Wnt signalling pathway antagonist, Dickkopf-1 (DKK-1) that has an inhibitory effect on the osteoblast formation [117] and inhibits nephronectin, an extracellular matrix protein, which helps the proliferation of osteoblasts [118]. Furthermore, TNF-a stimulates the production of M-CSF by MSCs that in turn, induce the differentiation of osteoclast progenitors [119].…”

Section: The Uncontrolled Immune Cell Response and Defective Bone Heamentioning

confidence: 99%

The roles of immune cells in bone healing; what we know, do not know and future perspectives

El-Jawhari

Jones

Giannoudis

2016

Injury

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“…DKK-1 seems to suppress the OPG production and disturb OPG-RANKL balance, which leads to bone lysis (188). Another role for TNF-is to suppress nephronectin, an extracellular matrix protein that induces the development and growth of osteoblasts (189). Additionally, TNF-induces the production of M-CSF by BM MSCs, which in turn, enhance the expression of the key osteoclastogenic cytokine receptor, RANK in the osteoclast progenitors (190).…”

Section: Cytokinesmentioning

confidence: 99%

Interactions Between Multipotential Stromal Cells (MSCs) and Immune Cells During Bone Healing

El-Jawhari

Jones

McGonagle

et al. 2016

Recent Advances in Stem Cells

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Abstract:The physiological process of bone healing takes place in three sequential stages: inflammation, repair and remodelling. Multipotential stromal cells (MSCs) are the key progenitor cells for osteoblasts and chondrocytes and are also imbued with immunomodulatory capabilities.Although MSCs are well known to be involved in osteogenesis during the later stages of repair, their role during the inflammatory phase and precise interactions with immune cells remain poorly understood. This chapter describes the current knowledge on cellular interactions during the bone repair as well as cytokines and growth factors mediating these processes. The roles of emerging innate immune cell populations, innate lymphoid cells are also discussed.Based on this current knowledge, we conclude that in addition to their differentiation during later bone repair stages, MSCs are likely to have a substantial involvement in the initial stage of bone healing by controlling the fate of inflammation. An improved understanding of complex cell interactions during bone repair has broad implications on optimising the treatment of the fracture complications including non-union.

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Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

Cited by 22 publications

References 26 publications

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D₃

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D₃

The roles of immune cells in bone healing; what we know, do not know and future perspectives

Interactions Between Multipotential Stromal Cells (MSCs) and Immune Cells During Bone Healing

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Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α

Cited by 22 publications

References 26 publications

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D3

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D3

The roles of immune cells in bone healing; what we know, do not know and future perspectives

Interactions Between Multipotential Stromal Cells (MSCs) and Immune Cells During Bone Healing

Contact Info

Product

Resources

About

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D₃

Expression of nephronectin is enhanced by 1α,25‐dihydroxyvitamin D₃