“…The median survival time ranges from one to two years, depending on the clinical stage [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. The prognostic factors include regional lymph node metastasis at the time of diagnosis, tumor and regional lymph node size, histological pattern, necrosis, and lymphovascular invasion [ 14 , 15 , 16 , 17 , 18 ]. Conversely, the prognostic significance of hypercalcemia remains controversial, and the Ki67 proliferation index does not demonstrate prognostic value [ 18 , 19 ].…”