Expression of peroxisome proliferator-activated receptor isoforms in the rat uterus during early pregnancy

Nishimura, Kyohei; Yamauchi, Nobuhiko; Chowdhury, Vishwajit S.; Torii, Mikinori; Hattori, Masa Aki; Kaneto, Masako

doi:10.1007/s00441-011-1208-4

Cited by 13 publications

(11 citation statements)

References 44 publications

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“…Previously published data indicate that PPARa and PPARb expression markedly increased in rodent endometrial stroma at the beginning of implantation [50] while PPARg mRNA level was higher during fertilization but declined at the beginning of implantation [50]. In the endometrium of pregnant cows, a lack of differences in PPARg mRNA level was noted [51], while in ovine endometrium the expression of PPARb stayed at a constant level on days 7-17 (peri-implantation period), PPARg declined from days 7 to 17 and PPARg peaked www.fhc.viamedica.pl first at day 9 and then on day 17 [49].…”

Section: Ppars In the Uterusmentioning

confidence: 94%

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Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

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Section: Ppars In the Uterusmentioning

confidence: 94%

“…Most experiments were carried out in the endometrium, where several essential events occur intended for preparation of the tissue to the embryo implantation, placentation and pregnancy sustain. The expression of all PPAR isoforms has been demonstrated in human, bovine, ovine, porcine and rodent endometrial tissue [48][49][50].…”

Section: Ppars In the Uterusmentioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

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“…A limited amount of data indicates that PPARs also play an important role in the regulation of uterine functions. This can be supported by the fact that all PPAR isoforms are expressed in the uterus of different species, including human, bovine, ovine, porcine, and murine (Bogacka and Bogacki 2011;Nishimura et al 2011). In addition, the diversified PPAR expression profile in the endometrium, which depends on the physiological status of animals, underlines their significance in this tissue.…”

Section: Introductionmentioning

confidence: 59%

Peroxisome proliferator activated receptor ligands affect porcine endometrial steroids production during the estrous cycle and early pregnancy: an in vitro study

Kurzyńska¹,

Bogacki²,

Chojnowska³

et al. 2016

CZECH J ANIM SCI

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AbstrAct:In the present study, we investigated the effect of PPAR ligands on progesterone (P 4 ) and 17β-estradiol (E 2 ) secretion, as well as 3β-hydroxysteroid dehydrogenase/Δ(5)-Δ(4) isomerase (3β-HSD) mRNA expression, in porcine endometrial slices collected on days 10-12 and 14-16 of the estrous cycle or early pregnancy. The explants were incubated in vitro for 6 h in the presence of PPARα ligands -WY-14643 (agonist) and MK 886 (antagonist); PPARβ ligands -L-165041 (agonist) and GW 9662 (antagonist); PPARγ ligands -15d-prostaglandin J 2 and rosiglitazone (agonists) and T0070907 (antagonist). During the estrous cycle, all PPAR ligands inhibited P 4 secretion during the mid-luteal phase (days 10-12). During early pregnancy, a stimulatory effect of PPARα agonist was observed during maternal recognition of pregnancy (days 10-12), while an inhibitory effect was observed at the beginning of implantation (days 14-16). PPAR ligands inhibited the expression of 3β-HSD mRNA on days 14-16 of the estrous cycle (β and γ isoforms) or pregnancy (α, β, γ isoforms) but did not affect gene expression on days 10-12 of the estrous cycle or early pregnancy. An inhibitory effect of PPARα, PPARγ, and PPARβ on E 2 secretion was observed during maternal recognition of pregnancy, but a stimulatory effect was observed during mid-(γ isoform) or late-luteal (β isoform) phases of the estrous cycle. Our study indicates, for the first time, that PPARs are engaged in P 4 and E 2 production in porcine endometrium. It is possible that the diverse receptivity of endometrial tissue to the PPAR ligands can be associated with the reproductive status of gilts.

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“…In contrast, PPARα and PPARδ are constantly expressed in the glandular epithelium at days 0.5-6.5 of pregnancy. Both PPARs are present in the endometrial stroma of during days 4.5-6.5 of the rat pregnancy [120]. PPARδ has been observed in the stroma at the site of implantation in mouse and rat [121,122].…”

Section: Peroxisome Proliferator-activated Receptormentioning

confidence: 99%

Role of nuclear receptors in blastocyst implantation

Vasquez

DeMayo

2013

Seminars in Cell & Developmental Biology

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The regulation of blastocyst implantation in the uterus is orchestrated by the ovarian hormones estrogen and progesterone. These hormones act via their nuclear receptors to direct the transcriptional activity of the endometrial compartments and create a defined period in which the uterus is permissive to embryo implantation termed the “window of receptivity”. Additional members of the nuclear receptor family have also been described to have a potential role in endometrial function. Much of what we know about the function of these nuclear receptors during implantation we have learned from the use of mouse models. Transgenic murine models with targeted gene ablation have allowed us to identify a complex network of paracrine signaling between the endometrial epithelium and stroma. While some of the critical molecules have been identified, the mechanism underlying the intricate communication between endometrial compartments during the implantation window has not been fully elucidated. Defining this mechanism will help identify markers of a receptive uterine environment, ultimately providing a useful tool to help improve the fertility outlook for reproductively challenged couples. The aim of this review is to outline our current understanding of how nuclear receptors and their effector molecules regulate blastocyst implantation in the endometrium.

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Expression of peroxisome proliferator-activated receptor isoforms in the rat uterus during early pregnancy

Cited by 13 publications

References 44 publications

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Peroxisome proliferator activated receptor ligands affect porcine endometrial steroids production during the estrous cycle and early pregnancy: an in vitro study

Role of nuclear receptors in blastocyst implantation

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