Expression of periostin in human breast cancer

Puglisi, Fabio; Puppin, Cinzia; Pegolo, Enrico; Andreetta, Claudia; Pascoletti, Gaetano; D’Aurizio, Federica; Pandolfi, Maura; Fasola, Gianpiero; Piga, Andrea; Damante, Giuseppe; Loreto, Carla Di

doi:10.1136/jcp.2007.052506

Cited by 82 publications

(100 citation statements)

References 26 publications

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“…In breast cancer, Puglisi et al [48] reported a significant correlation between the expression of POSTN and VEGF-A and the VEGF-R1 and VEGF-R2 receptors. Similarly, Siriwardena et al [26] showed that in oral squamous-cell carcinoma (OSCC) blood vessel density of POSTN-positive tumors was higher than those of POSTN-negative tumors.…”

Section: The Role Of Periostin In Angiogenesis and Lymphangiogenesismentioning

confidence: 99%

“…Increased expression of POSTN has been observed in various tumor types, including breast [44,48,[56][57][58], NSCLC [27,49,[59][60][61][62], colorectal [19,29,63], stomach cancers [64][65][66][67][68], pancreatic [32,69], prostate [70][71][72][73][74][75], ovarian cancer [76][77][78][79], and glioblastomas [80][81][82] (Table 1).…”

Section: Periostin Expression In Different Types Of Tumorsmentioning

confidence: 99%

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The role of periostin in neoplastic processes

Ratajczak‐Wielgomas

Dzięgiel

2015

Folia Histochem Cytobiol.

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Periostin, also called osteoblast-specific factor 2 (OSF-2), is a multifunctional glycoprotein that belongs to the group of matricellular proteins. Due to its characteristic molecular structure containing integrin-binding domains, periostin is capable of binding to multiple integrin receptors (avb3, avb5, a6b4), thus affecting the regulation of the intracellular signaling pathways associated with protein kinases PI3K/AKT and focal adhesion kinase (FAK). This protein thus plays a role in the adhesion process, in the migration of many cells, and importantly, epithelial-mesenchymal transition of cancer cells. Periostin also participates in the processes of angiogenesis and lymphangiogenesis, metastases of cancer cells, and remodeling of the extracellular matrix. Increased expression of periostin has been observed in various tumor types, including breast, NSCLC, colorectal, pancreatic, prostate, and ovarian cancers, as well as tumors of the head and neck, and glioblastomas. Many groups have recently reported on periostin's key role in tumor progression, which suggests that periostin can be considered a potential therapeutic target.

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Section: The Role Of Periostin In Angiogenesis and Lymphangiogenesismentioning

confidence: 99%

Section: Periostin Expression In Different Types Of Tumorsmentioning

confidence: 99%

The role of periostin in neoplastic processes

Ratajczak‐Wielgomas

Dzięgiel

2015

Folia Histochem Cytobiol.

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“…Recent studies have shown that PN is highly expressed in various human cancers, and have suggested that PN promotes tumor growth and metastasis (3)(4)(5). Moreover, PN is believed to promote tumor growth and metastasis, and to be correlated with poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

Kyutoku

Taniyama

Katsuragi³

et al. 2011

Int J Mol Med

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Abstract. Periostin (PN), a secreted adhesion-related protein expressed in the periosteum and periodontal ligaments, acts as a critical regulator of the formation and maintenance of bone and teeth, and also plays an important role in tumorigenesis. Although PN is highly expressed in various types of human cancers, its function is still unclear. In this study, we focused on the exon 17 region of PN, which is alternatively spliced out. To investigate the function of full-length PN with exon 17, we produced a neutralizing antibody (PN1-Ab) against the peptide encoded by exon 17. In vivo, administration of PN1-Ab significantly inhibited the growth of primary tumors as well as metastatic tumors, associated with prevention of bone destruction, resulting in increased survival of mice. consistent with in vivo data, the present in vitro study demonstrated that addition of full-length PN significantly inhibited cell adhesion and detached adherent cells, while PN1-Ab inhibited the action of PN in a dose-dependent manner. In addition, PN1-Ab significantly inhibited the proliferation, migration and invasion of 4T1 mouse breast cancer cells, which produced PN. Interestingly, PN1-Ab also inhibited the differentiation of osteoclasts. Overall, the present study demonstrated that PN plays a pivotal role in the progression and metastasis of breast cancer. Since administration of PN1-Ab prolonged cell survival through inhibition of the progression and metastasis of 4T1 cells, further development of the PN1-Ab such as generation of a humanized antibody may provide a new therapeutic agent against breast cancer.

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“…Furthermore, it has been demonstrated that periostin promotes adhesion and potentiates cancer cell motility by binding to integrins α ν β 3 and α ν β 5 (Gillan et al, 2002), and that forced expression of periostin induces invasive activity through epithelial-mesenchymal transition (EMT) in HEK-293 cells (Yan and Shao, 2006). Several studies correlate periostin expression with tumour angiogenesis and metastasis in human cancer Li et al, 2007;Malanchi et al, 2011;Puglisi et al, 2008;Sasaki et al, 2001aSasaki et al, ,b, 2003. Additionally, high pre-operative serum levels of periostin correlate with a poor prognosis in individuals with hepatocellular carcinoma after hepatectomy (Lv et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Promotion of periostin expression contributes to the migration of Schwann cells

Sonnenberg-Riethmacher

Miehe

Riethmacher

2015

Journal of Cell Science

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Neuregulin ligands and their ErbB receptors are important for the development of Schwann cells, the glial cells of the peripheral nervous system (PNS). ErbB3 deficiency is characterized by a complete loss of Schwann cells along axons of the peripheral nerves, impaired fasciculation and neuronal cell death. We performed comparative gene expression analysis of dorsal root ganglia (DRG) explant cultures from ErbB3-deficient and wild-type mice in order to identify genes that are involved in Schwann cell development and migration. The extracellular matrix (ECM) gene periostin was found to exhibit the most prominent down regulation in ErbB3-deficient DRG. Expression analysis revealed that the periostin-expressing cell population in the PNS corresponds to Schwann cell precursors and Schwann cells, and is particularly high in migratory Schwann cells. Furthermore, stimulation of Schwann cells with neuregulin-1 (NRG1) or transforming growth factor β (TGFβ-1) resulted in an upregulation of periostin expression. Interestingly, DRG explant cultures of periostindeficient mice revealed a significant reduction of the number of migrating Schwann cells. These data demonstrate that the expression of periostin is stimulated by ErbB ligand NRG1 and influences the migration of Schwann cell precursors.

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Expression of periostin in human breast cancer

Abstract: Results indicate that the aberrant gene expression of periostin in breast cancer cells is associated with an abnormal nuclear localisation of the protein. The nuclear localisation of periostin in breast cancer may induce significant biological effects.

Cited by 82 publications

References 26 publications

The role of periostin in neoplastic processes

The role of periostin in neoplastic processes

Role of periostin in cancer progression and metastasis: Inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

Promotion of periostin expression contributes to the migration of Schwann cells

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