Expression of Perilipin and Adipophilin in Nonalcoholic Fatty Liver Disease; Relevance to Oxidative Injury and Hepatocyte Ballooning

Fujii, Hideki; Ikura, Yoshihiro; Arimoto, Junko; Sugioka, Kenichi; Iezzoni, Julia C.; Park, Sang Hoon; Naruko, Takahiko; Itabe, Hiroyuki; Kawada, Norifumi; Caldwell, Stephen H.; Ueda, Makiko

doi:10.5551/jat.2055

Cited by 103 publications

(90 citation statements)

References 29 publications

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“…Sequence similarity of Plin2 to the Plin family led to the discovery that [15]. Thus, expression of Plin2 in the surface of LD in the hepatocytes is a pathophysiological change in human fatty liver disease.…”

Section: Plin2 (Adipose Differentiation-related Protein: Adrp)mentioning

confidence: 99%

Role of lipid droplet proteins in liver steatosis

Okumura

2011

J Physiol Biochem

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Section: Plin2 (Adipose Differentiation-related Protein: Adrp)mentioning

confidence: 99%

Role of lipid droplet proteins in liver steatosis

Okumura

2011

J Physiol Biochem

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“…Ballooned hepatocytes are enlarged, with swollen, rarefied, pale cytoplasm and, usually, show a large, hyperchromatic nucleus, often with a prominent nucleolus. They might be the result of alterations in intermediate filament cytoskeleton [61] and/or presence of microvesicular steatosis [62] . The histological recognition of hepatocellular ballooning can show significant inter-observer variation [63] .…”

Section: Adult Nashmentioning

confidence: 99%

Histopathology of Non-Alcoholic Fatty Liver Disease

Brunt

2009

Clinics in Liver Disease

114

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Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease (NAFLD) are measured. Histological evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD, i.e. nonalcoholic steatohepatitis (NASH) and fibrosis. Included in the lesions of NAFLD are steatosis, lobular and portal inflammation, hepatocyte injury in the forms of ballooning and apoptosis, and fibrosis. However, patterns of these lesions are as distinguishing as the lesions themselves. Liver injury in adults and children due to NAFLD may have different histological patterns. In this review, the rationale for liver biopsy, as well as the histopathological lesions, the microscopically observable patterns of injury, and the differential diagnoses of NAFLD and NASH are discussed.

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“…IGF1 is derived mainly from the liver, and low serum IGF1 is associated with increased human hepatic steatosis (Völzke et al 2009). Diet A cat livers had increased expression of a number of genes related to hepatic steatosis, including DGAT1 (Millar et al 2006), perlipin (Fujii et al 2009), and fatty acid-binding protein 1. Interestingly, glycerol kinase expression was also upregulated in the livers of both MSG-containing diet groups A and C; and increased glycerol reutilization has previously been noted in the adipose tissue of MSG-treated rats (Dolnikoff et al 2001), where enhanced glycerol utilization has been suggested to contribute to the development of obesity in these animals.…”

Section: Discussionmentioning

confidence: 99%