Expression of p53 Protein After Nonablative Rejuvenation: The Other Side of the Coin

Abstract

The increase in epidermal p53 expression after IPL treatment could increase the risk of skin neoplasia by intense pulsed light-induced DNA damage which may lead to dysregulation of apoptosis and initiation of skin cancer.

Side effects from intense pulsed light: Importance of skin pigmentation, fluence level and ultraviolet radiation—A randomized controlled trial

“…A recently published paper by El‐Domyati et al reported a significant increase in the cellular expression of p53 at 3 months after IPL ( P < 0.04), indicating that IPL may increase the risk of skin neoplasia . This finding was based on histological staining of p53 in a limited number of subjects ( n = 6 subjects) with FST III–IV after exposure to IPL of 30–35 J/cm 2 , double pulse with a 6‐milliseconds width and a delay of 20–30 milliseconds between pulses . In the present study, a total of 15 subjects with FST II–IV were exposed to IPL of 3 × 46 J/cm 2 , single pulse of 40 milliseconds and expression of p53 was quantified by RT‐qPCR.…”

“…In this regard, few studies have investigated the effect of IPL or other light‐based modalities on histopathological markers such as p53. A recently published paper by El‐Domyati et al reported a significant increase in the cellular expression of p53 at 3 months after IPL ( P < 0.04), indicating that IPL may increase the risk of skin neoplasia . This finding was based on histological staining of p53 in a limited number of subjects ( n = 6 subjects) with FST III–IV after exposure to IPL of 30–35 J/cm 2 , double pulse with a 6‐milliseconds width and a delay of 20–30 milliseconds between pulses .…”

Intense Pulsed Light: Friend or Foe? Molecular Evidence to Clarify Doubts

“…The UV-induced metabolic switch to catabolic pathways for ATP generation seems to be mediated by the activation of AMPK, which positively regulates downstream p53 activation (18) Our data supports p53 activation induced by IPL, which impacted skin cells apoptosis given by the increased levels of cleaved caspase-3. The overexpression of epidermal p53 was previously reported in patients with Fitzpatrick skin type III to IV after IPL treatment, and was related to dysregulation of apoptosis and increased risk of skin cancer (19). IPL irradiation of skin previously exposed to DMBA induced focal hyperplasia in the dermis with negligible inflammatory infiltrate, as described earlier (11).…”

New lasers and light sources – old and new risks?

“…Depending on the device generation, however, the patient's skin may also be exposed to and damaged by infrared and blue light as well as UV radiation . Consequently, a wide range of side effects may be expected, including erythema, skin aging, potential induction of neoplasms , phototoxic and photoallergic reactions, and many more (FA ET 3 2009).…”