Expression of p53 in Inverted Papilloma and Malignancy Associated with Inverted Papilloma

Gujrathi, Chetan; Pathak, Irvin; Freeman, Jeremy L.; Sylvia, L.

doi:10.2310/7070.2003.35293

Cited by 13 publications

(8 citation statements)

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“…The tumor suppression function of p53 is related to many cancers reported by Katori et al and Gujrathi et al [22, 23]. They suggested that testing for p53 may help to screen out papilloma lesions with a potential for dysplasia or carcinoma; however, we did not find it significant in multivariate analysis.…”

Section: Discussioncontrasting

confidence: 74%

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Tsou

Huang

Wang

et al. 2014

BioMed Research International

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The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.

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Section: Discussioncontrasting

confidence: 74%

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Tsou

Huang

Wang

et al. 2014

BioMed Research International

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“…Gujrathi et al [31] found that four of the five cases of malignancy associated with IP demonstrated overexpression of p53 and none of the benign cases of IP demonstrated overexpression. They indicated that overexpression of p53 may serve as a marker for malignant transformation of IP.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Öncel

Cosgul

Çallı

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Using a molecular genetic approach, we try to confirm the molecular alterations of inverted papilloma and clarify its status as a putative precursor lesion of sinonasal squamous cell carcinoma. To better understand its genetics, we investigated the immunohistochemical protein expression patterns of cell-cycle-regulators p53, p63, p21, p27 and proliferation marker Ki-67 in 22 inverted papilloma and 9 squamous cell carcinoma of the sinonasal tract. Significantly elevated levels of p53 and p63 in squamous cell carcinoma of sinonasal tract compared with inverted papilloma were revealed. Ki-67-stained neoplastic cell nuclei were found in a significantly higher percentage of squamous cell carcinoma of sinonasal tract than in inverted papilloma, whereas no variation of p21 and p27 expression was identified. This work first examined the immunohistochemical overexpression of p63 in sinonasal inverted papilloma and squamous cell carcinoma. In conclusion, this is a first study shedding light on the expression of p63 in tumors of paranasal sinuses.

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“…52,61,77 Over-expression of p53 may serve as a marker for malignant transformation of inverted papilloma. 61,66,78 Screening inverted papilloma patients for p21 may also identify those at risk of developing dysplasia or SCC. 61 In inverted papilloma cases associated with malignancy, an inverse relationship has been found between HPV and p53 over-expression (i.e.…”

Section: Aetiology Of Malignant Transformationmentioning

confidence: 99%

Sinonasal inverted papilloma: narrative review

2010

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In order to compare different studies and to enable meta-analysis of the literature, there should be a universally accepted staging and classification system for sinonasal inverted papilloma. Further research on the aetiology of sinonasal inverted papilloma, and on biological markers for its recurrence and malignant transformation, is required. To enable meaningful future research, we would encourage multicentre participation with a consensus on management.

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Expression of p53 in Inverted Papilloma and Malignancy Associated with Inverted Papilloma

Cited by 13 publications

References 0 publications

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Evaluation of P53, P63, P21, P27, Ki-67 in Paranasal Sinus Squamous Cell Carcinoma and Inverted Papilloma

Sinonasal inverted papilloma: narrative review

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