Expression of p16 protein in infantile hemangioma

Abstract

Abstract. The present study aimed to investigate the expression and significance of p16 in the occurrence, development and regression of infantile hemangioma (IH). The expression of p16 was examined in proliferating, involuting hemangioma and normal tissues using immunohistochemical techniques. The expression of p16 was significantly lower in proliferating hemangioma than in involuting hemangioma, and was significantly lower in the involuting hemangioma than in normal tissues. Significant differences were found between the three groups (P<0.05). The results indicate that p16 may be important in the regression of IH endothelial cells and in anti-angiogenesis. There is a certain association between p16 expression and the regression of hemangioma. This provides a theoretical basis for the further study of the pathological mechanisms of p16 in hemangioma and potential gene therapies that may treat this disease.

Giant Ulcerative Hemangioma in a Newborn

“…In contrast, the expression of p16 protein is increased within the period of IH regression, inhibiting the hemangioma endothelial cell CDK4/CDK6 activity, leading to cell cycle arrest [11]. The subsequent inhibition of the proliferation of the hemangioma endothelial cells promotes the involution of IH [11]. The significant difference between the results in the investigative lesions is a promising new entity in the differentiation between the IH capacity of proliferation and potential of rapid growth, which could result in further complication.…”

“…These results suggest that the p16 protein is present at a low level of expression in proliferating hemangioma and it cannot inhibit the hemangioma endothelial cell CDK4/CDK6 activity as a result, wich subsequently makes it unable to prevent the cell from entering the G1 phase to S phase transition [11]. Therefore, the cell proliferation becomes uncontrolled, leading to the excessive proliferation of the endothelial cells, accelerating hemangioma proliferation [11].…”

“…Therefore, the cell proliferation becomes uncontrolled, leading to the excessive proliferation of the endothelial cells, accelerating hemangioma proliferation [11]. In contrast, the expression of p16 protein is increased within the period of IH regression, inhibiting the hemangioma endothelial cell CDK4/CDK6 activity, leading to cell cycle arrest [11]. The subsequent inhibition of the proliferation of the hemangioma endothelial cells promotes the involution of IH [11].…”

“…Recent Wang S et al investigated the expression of p16 protein in IH, detected by immunohistochemistry, observing that the expression level of p16 protein in the proliferating hemangioma was lower than that in the involuting hemangioma and that the expression level of p16 protein in the involuting hemangioma was lower than that in the normal tissue [11]. These results suggest that the p16 protein is present at a low level of expression in proliferating hemangioma and it cannot inhibit the hemangioma endothelial cell CDK4/CDK6 activity as a result, wich subsequently makes it unable to prevent the cell from entering the G1 phase to S phase transition [11].…”