Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps

Lu, Xin-Jiang; Zhang, X. H.; Wang, H.; Long, Xiao; You, Xueji; Gao, Qianyan; Cui, Yunan; Liu, Z.

doi:10.1111/j.1398-9995.2008.01829.x

Cited by 41 publications

(62 citation statements)

References 23 publications

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“…In a recent random sample survey study with over 52,000 adults aged 18 to 75 years in 12 European countries, the prevalence of self-reported current asthma (5.1-16.8%) was found to be strongly associated with CRS appropriate symptoms (adjusted OR, 3.47; 95% CI, 3.20 to 3.76) in all ages, in both men and women, irrespective of smoking behavior. 293 The reported incidence of asthma varies from 2% to 38% in patients with CRS, [294][295][296][297][298][299] 2% to 66% in CRSwNP, 289, and 68% to 91% in refractory CRSwNP. 290,299 Among these reports, the prevalence of asthma in patients with CRSsNP or CRSwNP appears to be lower in Asians than whites.…”

Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

548

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Viib Crssnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

548

888

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“…OPN expression is upregulated in nasal tissue samples taken from asthmatic patients with chronic rhinosinusitis [10], and allergic patients undergoing successful long-term venom allergen immunotherapy show increased levels of serum OPN [11]. Moreover, OPN is expressed and functional in peripheral blood eosinophils of atopic human subjects [12], and is also involved in the in vitro migration of eosinophils isolated from asthmatics [13].…”

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confidence: 99%

Osteopontin expression and relation to disease severity in human asthma

Samitas¹,

Ζervas²,

Vittorakis³

et al. 2010

European Respiratory Journal

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Recent studies have associated osteopontin (OPN) with allergic inflammation; however, its role in human asthma remains unclear. The aim of this study was to measure OPN levels in the serum, bronchoalveolar lavage fluid (BALF) and bronchial tissue of healthy controls and asthmatics, identify cellular sources of OPN and examine possible correlations between OPN expression, disease severity and airway remodelling.Serum samples were obtained from 35 mild-to-moderate asthmatics, 19 severe asthmatics and 17 healthy controls in the steady state and in cases of exacerbation. Of these subjects, 29 asthmatics and nine controls underwent bronchoscopy with endobronchial biopsy and BALF collection. OPN expression was determined by ELISA and immunohistochemistry/immunofluorescence. Reticular basement membrane thickness and goblet cell hyperplasia were also determined.Serum and BALF OPN levels were significantly increased in all asthmatics in the steady state, whereas serum levels decreased during exacerbations. OPN was upregulated in the bronchial tissue of all patients, and expressed by epithelial, airway and vascular smooth muscle cells, myofibroblasts, T-lymphocytes and mast cells. OPN expression correlated with reticular basement membrane thickness and was more prominent in subepithelial inflammatory cells in severe compared to mild-to-moderate asthma.OPN expression is upregulated in human asthma and associated with remodelling changes, and its subepithelial expression correlates with disease severity.

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“…The expression of OPN protein in the nasal mucosa of healthy and AR subjects was predominantly in the nucleus of the epithelial and endothelial cells (glandular and vesicular). Similarly, OPN expression has also been seen intracellularly in other nasal biopsies [12], as well as bronchial biopsies [10,11,16]. …”

Section: Discussionmentioning

confidence: 99%

“…OPN is a pleiotropic cytokine normally expressed by many cell types [7], which has been implicated in various diseases [8], including asthma [9-11] and chronic rhinosinusitis [12]. OPN can be expressed in eosinophils, which could argue its involvement in allergic eosinophilic inflammation [13].…”

Section: Introductionmentioning

confidence: 99%

Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment

O’Neil

Malmhäll

Samitas

et al. 2010

All Asth Clin Immun

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BackgroundOsteopontin (OPN) is a multifunctional cytokine that has been primarily investigated in Th1 diseases. Recently, it has also been implicated in Th2-mediated allergic diseases, such as asthma. The expression of OPN in allergic rhinitis (AR) is currently unknown, as is the effect of intranasal glucocorticosteroids (GCs) on that expression.MethodsSubjects with AR were randomised to receive treatment with fluticasone propionate (FP) (n = 12) or a placebo (n = 16) over the grass pollen season and nasal biopsies were taken prior to, and during the season. OPN expression in the nasal mucosa was examined with immunohistochemistry. Healthy non-AR controls (n = 5) were used as a comparator.ResultsOPN expression was detected in epithelial cells, subepithelial infiltrating/inflammatory cells and cells lining the vessels and glands of all subjects. Comparison of the pre- and peak-pollen season biopsy sections in placebo treated patients revealed no increase in OPN expression during the grass pollen season (5.7% vs 6.4%). Treatment with a local glucocorticosteroid did not alter the expression of OPN during pollen exposure (6.2% vs 6.7%).ConclusionOPN has been increasingly associated with the pathogenesis of various Th2-mediated diseases. However, our finding that the OPN expression in the nasal mucosa of AR patients is not significantly affected by allergen exposure and is comparable to that of the healthy controls, suggests that intracellular OPN is not directly involved in the pathogenesis of allergic rhinitis.

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Expression of osteopontin in chronic rhinosinusitis with and without nasal polyps

Abstract: The expression of OPN is upregulated in CRS. The mutual regulatory interactions between OPN and inflammatory cytokines suggest that OPN may play an important role in the pathogenesis of CRS.

Cited by 41 publications

References 23 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Osteopontin expression and relation to disease severity in human asthma

Quantitative expression of osteopontin in nasal mucosa of patients with allergic rhinitis: effects of pollen exposure and nasal glucocorticoid treatment

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