Expression of Nrf2 protein in serum of patients with rheumatoid arthritis: A novel indicator for disease activity and disease prognosis

Wang, Huijie; Xia, Guangtao; Guan, Xin; Wang, Li; Qin, Lei; Fu, Min

doi:10.1016/j.clinbiochem.2022.12.011

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Chronic and inflammatory interstitial pneumonia was observed with increased levels of TNF-α, IL-6, and TGF-β in the lungs [175]. Wang et al found that the serum nuclear factor erythroid 2-related factor 2 (Nrf2) levels in patients with RA were significantly associated with ILD, and that the Nrf2-related antioxidant pathway was involved in the development of oxidative stress-mediated RA-ILD [176].…”

Section: Oxidative Stressmentioning

confidence: 99%

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Kim,

Yang,

Kim

2023

IJMS

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Interstitial lung disease (ILD) is one of the most serious extra-articular complications of rheumatoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of RA-ILD remains poorly understood, appropriate therapeutic strategies and biomarkers have not yet been identified. Thus, the goal of this review was to summarize and analyze the reported data on the etiology and pathogenesis of RA-ILD. The incidence of RA-ILD increases with age, and is also generally higher in men than in women and in patients with specific genetic variations and ethnicity. Lifestyle factors associated with an increased risk of RA-ILD include smoking and exposure to pollutants. The presence of an anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity also increase the risk of RA-ILD. We also explored the roles of biological processes (e.g., fibroblast–myofibroblast transition, epithelial–mesenchymal transition, and immunological processes), signaling pathways (e.g., JAK/STAT and PI3K/Akt), and the histopathology of RA involved in RA-ILD pathogenesis based on published preclinical and clinical models of RA-ILD in animal and human studies.

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Section: Oxidative Stressmentioning

confidence: 99%

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Kim,

Yang,

Kim

2023

IJMS

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Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Kim,

Yang,

Kim

2023

Preprint

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Interstitial lung disease (ILD) is one of the most serious extra-articular complications of rheu-matoid arthritis (RA), which increases the mortality of RA. Because the pathogenesis of RA-ILD remains poorly understood, appropriate therapeutic strategies and biomarkers have not yet been identified. Thus, the goal of this review was to summarize and analyze the reported data on the etiology and pathogenesis of RA-ILD. The incidence of RA-ILD increases with age, and is also generally higher in men than in women and in patients with specific genetic variations and eth-nicity. Lifestyle factors associated with an increased risk of RA-ILD include smoking and exposure to pollutants. The presence of an anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity also increase the risk of RA-ILD. We also explored the roles of biological processes (e.g., fibroblast–myofibroblast transition, epithelial–mesenchymal transition, and immunological processes), signaling pathways (e.g., JAK/STAT and PI3K/Akt), and the his-topathology of RA involved in RA-ILD pathogenesis based on published preclinical and clinical models of RA-ILD in animal and human studies.

show abstract

Expression of Nrf2 protein in serum of patients with rheumatoid arthritis: A novel indicator for disease activity and disease prognosis

Cited by 2 publications

References 30 publications

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease

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