Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions

Bal, Amanjit; Joshi, Kusum; Logasundaram, Rajesh; Radotra, BD; Singh, Rajinder

doi:10.1186/1746-1596-3-23

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…The correlation between its expression and tumor metastasis is tumor specific. It is confirmed that nm23-H1 expression is negatively related to the metastasis of breast cancer, gastric cancer, liver cancer, esophageal cancer, lung cancer, and lymphoma (Boissan and Lacombe, 2006;Guan-Zhen et al, 2007;Bal et al, 2008;Niitsu et al, 2008) and positively related to the metastasis of ovarian cancer and prostate cancer (Youn et al, 2008). Some studies also found that the nm23-H1 expression level is not related to metastatic potential (Murakami et al, 2008;Wang et al, 2008).…”

Section: Discussionsupporting

confidence: 74%

Inhibitory effect of upregulated DR-nm23 expression on invasion and metastasis in colorectal cancer

et al. 2013

European Journal of Cancer Prevention

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To explore the role of DR-nm23 in the regulation of colorectal cancer invasion and metastasis. Immunohistochemistry assay and in-situ nucleic acid hybridization were carried out to analyze the protein and mRNA expression of DR-nm23 in patient samples. The molecular cloning technique was applied to construct the recombinant lentiviral expression vector pGC-FU-DR-nm23-GFP. Lentiviral infection was used to introduce overexpression of exogenous DR-nm23 in SW620 colorectal cancer cells. Both in-vitro cell experiments and an in-vivo xenograft tumor model assay were carried out to determine the role of DR-nm23 in the regulation of colorectal cancer proliferation, invasion, and metastasis. Our data here showed that the expression level of DR-nm23 in colorectal cancer tissue was significantly lower than that in adenoma and normal tissue. The expression level of DR-nm23 was also found to be negatively correlated with lymph node metastasis and positively correlated with the degree of tumor differentiation. Besides, introduced overexpression of DR-nm23 in SW620 cells through lentiviral infection resulted in significant inhibition of its proliferation rate in vitro and growth rate in vivo. The cell migration ability in vitro and metastatic potential in vivo were also impaired at the same time. Our current study suggested that DR-nm23 may participate in the regulation of differentiation of colorectal cancer cells. Its downregulated expression is closely related to the invasion and metastasis of colorectal cancer. Thus, expression status of DR-nm23 may act as a potential prognostic factor in patients with colorectal cancer.

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Section: Discussionsupporting

confidence: 74%

Inhibitory effect of upregulated DR-nm23 expression on invasion and metastasis in colorectal cancer

et al. 2013

European Journal of Cancer Prevention

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“…Little is known about the molecular mechanisms that drive the development and prog ression of malignant tumors within fibroadenomas. Comparative studies that analyzed various molecular markers in fibroadenomas and breast carcinomas failed however to identify the potential drivers [35,36]. However, a clonality study of Kuijper et al [37] indicated that fibroadenomas possessed a potential to progress in an epithelial direction (carcinoma) or in a stromal direction (phyllodes tumor).…”

Section: Discussionmentioning

confidence: 99%

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

2013

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IntroductionFibroadenomas are the most common benign breast tumors in young women. Infarction is rarely observed in fibroadenomas and when present, it is usually associated with pregnancy or lactation. Infarction can exceptionally occur as a complication of previous fine-needle aspiration biopsy or during lactation and pregnancy.Materials and methodsRetrospective review of 650 cases of fibroadenomas diagnosed at our institution during the 8-years period identified two cases of fibroadenomas with infarction (rate ~0.3%).ResultsTwo partially infarcted fibroadenomas were diagnosed on core biopsy and frozen section in an adolescent girl (13 years old) and in a young woman (25 years old), respectively. No preceding fine-needle aspiration biopsy was performed in these cases, nor were the patients pregnant or lactating at the time of the diagnosis.ConclusionSpontaneous infarction within fibroadenoma is a rare phenomenon in younger patients. The presence of necrosis on core biopsy or frozen section should be cautiously interpreted and is not a sign of malignancy.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1556060549847356

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“…The Nm23-H1 gene is a metastasis suppressor gene, the low expression of which can promote tumor occurrence and metastasis during tumor progression (8). As Nm23-H1 was originally identified as a metastasis suppressor protein, its expression has been correlated with tumor metastatic potential in various types of human carcinoma, primarily in ductal breast cancer (9) and CRC (7). Low expression levels of Nm23-H1 have been associated with poor prognosis in gastric adenocarcinoma, breast cancer, hepatocellular carcinoma and ovarian carcinoma (9–12).…”

Section: Introductionmentioning

confidence: 99%

“…As Nm23-H1 was originally identified as a metastasis suppressor protein, its expression has been correlated with tumor metastatic potential in various types of human carcinoma, primarily in ductal breast cancer (9) and CRC (7). Low expression levels of Nm23-H1 have been associated with poor prognosis in gastric adenocarcinoma, breast cancer, hepatocellular carcinoma and ovarian carcinoma (9–12). p53 is a transcription factor involved in regulating cell cycle arrest and apoptosis in response to DNA damage and cellular stress, and is thereby critical in protecting cells from malignant transformation (13,14).…”

Section: Introductionmentioning

confidence: 99%

Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer

Zhao

et al. 2016

Oncology Letters

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Molecular tumor markers hold considerable promise for accurately predicting the recurrence and progression of colorectal cancer (CRC) in patients. However, in the majority of cases, single marker analysis has been found to have low accuracy, and is of little practical use in clinical practice. The present study investigated the prognostic value of the combined detection of the protein expression of metastasis suppressor 23-H1 (Nm23-H1) and p53 using immunohistochemical analysis, and the mRNA expression levels were analyzed using reverse transcription-quantitative polymerase chain reaction in 110 cases of stage II and III CRC. The results revealed that the expression levels of Nm23-H1 in CRC tissues were lower, compared with those in normal tissues (χ2=18.249; P<0.001), and the protein expression levels of p53 were higher in the CRC tissues (χ2=23.940; P<0.001); although the mRNA expression levels of Nm23-H1 and p53 presented with the same trend. The protein expression of Nm23-H1 was correlated with lymph node metastases (χ2=11.847; P=0.001) and pathological patterns (χ2=6.911; P=0.032). However, it did not correlate with patient gender or age, or with tumor World Health Organization classification or invasive depth (P>0.05). No significant correlation was observed between the expression of p53 and clinicopathological features (P>0.05). Patients with CRC with Nm23-H1(+)/p53(−) tumors had increased survival rates, with a five-year overall survival rate of 83.8% and a five-year disease-free survival rate of 70.2%. The five-year overall survival rates in other study cohorts were lower, compared with the Nm23-H1(+)/p53(−) group (P<0.0125), and this was the same for the five-year disease-free survival rate (P<0.0125). In conclusion, the present study demonstrated that the combined detection of the protein expression of Nm23-H1 and p53 was associated with the long term survival rates of patients with stage II and III CRC; and this may offer potential for use as a predictor of survival rates in patients with CRC.

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Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions

Cited by 10 publications

References 26 publications

Inhibitory effect of upregulated DR-nm23 expression on invasion and metastasis in colorectal cancer

Inhibitory effect of upregulated DR-nm23 expression on invasion and metastasis in colorectal cancer

Infarcted fibroadenoma of the breast: report of two new cases with review of the literature

Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer

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