Expression of nm23-H1 Is Associated with Poor Prognosis in Peripheral T-Cell Lymphoma, Not Otherwise Specified

Niitsu, Nozomi; Nakamine, Hirokazu; Okamoto, Masanori

doi:10.1158/1078-0432.ccr-10-2999

Cited by 16 publications

(12 citation statements)

References 18 publications

(16 reference statements)

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“…Prior studies have explored and suggested tissuebased/ phenotypic prognostic markers for PTCL-NOS including proliferation gene signature or markers, 24,25 TP53 expression, 26 Epstein-Barr virus RNA, 27 the metastasis- suppressor gene product nm23-H1, 28 CCR4, 29 VEGF mRNA, 30 and FOXP1. 31 Although not a primary goal of the study, use of our immunophenotypic panel may also provide information on prognosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of a Defined Immunophenotypic and Molecular Genetic Approach for Peripheral T/NK-cell Lymphomas

Hsi¹,

Said²,

Macon³

et al. 2014

American Journal of Surgical Pathology

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The diagnosis of peripheral T-cell and NK-cell lymphomas (PTNKCL) is difficult with few standards for required ancillary studies. We evaluated a series of PTNKCLs using a tiered approach to immunohistochemistry and molecular genetic characterization to document diagnostic accuracy and clinical relevance. Seven hematopathologists reviewed 374 cases that included PTNKCL and non-PTNKCL cases to mimic diagnostic practice. Cases received tier 0, 1, and 2 diagnoses by 3 independent pathologists, on the basis of hematoxylin and eosin stains and progressive immunohistochemistry panels. A tier 2b diagnosis was rendered when gene rearrangement data were available, and a final consensus diagnosis was rendered after discussion of each case. Across all 374 cases, consensus agreement was 92.5%. For PTNKCLs, World Health Organization subclassification was possible in 16.5%, 37.1%, 82.8%, and 85.9% of individual reviewer diagnoses at tier 0, 1, 2, and 2b, respectively. Gene rearrangement contributed to a change in diagnosis in 51 of 647 (8%) individual reviews. Following this algorithm may provide prognostic information on the basis of individual marker expression in common PTNKCL types (CD4 in peripheral T-cell lymphoma, not otherwise specified and PD-1 in angioimmunoblastic T-cell lymphoma). This evidence-based approach to the diagnosis of PTNKCL informs practicing pathologists, clinical trial designers, and policy-makers regarding required ancillary studies.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of a Defined Immunophenotypic and Molecular Genetic Approach for Peripheral T/NK-cell Lymphomas

Hsi¹,

Said²,

Macon³

et al. 2014

American Journal of Surgical Pathology

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“…For example, nm23 and HER-2 were negatively correlated with tumor metastasis and prognosis. Interestingly, HER-2 has been exploited as a promising candidate for peptide-based cancer vaccines (Kedrin et al, 2009;Lekka et al, 2010;Niitsu et al, 2011). PTEN, p53, and c-myc, which are all well known to play important roles in carcinogenesis, have also been shown to be associated with prognosis (Schade et al, 2009;Chen et al, 2011;Huang et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Human Embryonic Stem Cells - a Potential Vaccine for Ovarian Cancer

Zhang

Chen²,

Chang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…For example, nm23 and HER-2 were negatively correlated with tumor metastasis and prognosis. Notably, HER-2 has been exploited as a promising candidate for peptide-based cancer vaccines (9)(10)(11)(12). PTEN, p53, and c-myc, which are all well known to play important roles in carcinogenesis, have also been shown to be associated with prognosis (13)(14)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Vaccination with embryonic stem cells generates effective antitumor immunity against ovarian cancer

Zhang

Chen

Chang

et al. 2012

International Journal of Molecular Medicine

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To date, only a few studies have suggested that human embryonic stem cells (hESCs) might effectively immunize against colon and lung cancer. The purpose of this study was to investigate the therapeutic potential of hESCs as a vaccine to induce widespread antitumor effects in different animal models and various types of cancer. C57BL/6 mice with ID8 ovarian cancer cell and Fischer 344 rats with NuTu-19 ovarian cancer cell models were used. Fifty-four mice were divided into six groups with nine mice in each group. Each mouse was immunized with pre-inactivated hESCs (H9) or mouse embryonic stem cells (mESCs; IVP-ES1) or ID8 or phosphate-buffered saline (PBS). Twenty-four rats were divided into four groups with six rats in each group, each rat immunized with pre-inactivated hESCs (H9) or NuTu-19 or PBS. After the vaccination, each mouse was challenged with live ID8 cells subcutaneously, and each rat was challenged with live NuTu-19 cells intraperitoneally. We discovered that vaccination of mice with the hESC line H9 and the mESC line IVP-ES1 generated consistent cellular and humoral immune responses against ID8 ovarian cancer. H9 and IVP-ES1 vaccinated mice obtained antitumor immune protection, and H9 vaccinated rats had the longest survival time and least distant metastases. No evidence of side-effects was observed. We also compared the immunogenicity against ovarian cancer between the hESC line, H9, and the mESC line, IVP-ES1, that derived from the inner cell mass in different species. We found that there were no significant differences between them. Furthermore, immunohistochemical staining revealed that several oncogenes and tumor suppressor genes, such as HER-2, C-myc, p53, and nm23, were expressed in H9, many of which were also shared by ovarian cancer. hESC vaccines can induce antitumor effects in two animal models and in ovarian cancer, indicating that the activity of the vaccine is universal, and, more importantly, it is safe.

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Expression of nm23-H1 Is Associated with Poor Prognosis in Peripheral T-Cell Lymphoma, Not Otherwise Specified

Cited by 16 publications

References 18 publications

Diagnostic Accuracy of a Defined Immunophenotypic and Molecular Genetic Approach for Peripheral T/NK-cell Lymphomas

Diagnostic Accuracy of a Defined Immunophenotypic and Molecular Genetic Approach for Peripheral T/NK-cell Lymphomas

Human Embryonic Stem Cells - a Potential Vaccine for Ovarian Cancer

Vaccination with embryonic stem cells generates effective antitumor immunity against ovarian cancer

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