Expression of nitric oxide synthase in pleomorphic adenomas of the parotid

Brennan, Peter A.; Umar, T.; Buckley, Jayne; Zaki, G.A.; Langdon, John H.; Spedding, Anne V.; Peters, Walter J.

doi:10.1054/bjom.1999.0454

Cited by 23 publications

(28 citation statements)

References 17 publications

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“…Although the localization of iNOS and the HSPss and their roles in normal salivary gland are well documented [1,5,10,21,31], little information is available on their role in neoplasm of salivary gland [4,5]. The present study showed iNOS and the HSPs are widely localized at neoplastic epithelium in pleomorphic adenoma.…”

Section: Discussionmentioning

confidence: 45%

“…Both mesenchymal and neoplastic epithelial cells exist in the stromal tissues of pleomorphic adenoma [9]. The expression of iNOS and HSPs in normal salivary glands are observed in epithelial cells such as ductal and myoepithelial cells, but not in stromal cells [1,5,31]. The positive cells in stromal tissues may be neoplastic epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…The sections were rinsed in PBS and incubated with streptavidin-biotin peroxidase complex (SAB-PO kit; Histofine, Nichirei, Tokyo, Japan) according to manufacturer procedure, reacted with 3,3'-diaminobenzidine (DAB) and hydrogen peroxide for 5 min at room temperature, rinsed in distilled water, dehydrated, and mounted in Malinol. As a positive control, the staining in the normal salivary glands adjacent to the tumors was used with reference to previous reports [5,31]. All individuals were informed about the purpose of the study and consented to the study.…”

Section: Methodsmentioning

confidence: 99%

“…E-mail: yoshi-ab@hoku-iryo-u.ac.jp gland have been well documented [1,5,10,21,31], little information is available on them in the pleomorphic adenoma. The present study investigates the localization of iNOS and HSPs in pleomorphic adenoma.…”

Section: Introductionmentioning

confidence: 99%

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An Immunohistochemical Study of the Localization of Inducible Nitric Oxide Synthase (iNOS) and Heat Shock Protein (HSP) in Pleomorphic Adenoma

Yamaguchi

Abiko

Nishimura

et al. 2004

Acta Histochem. Cytochem

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The present study investigated the localization of inducible NOS (iNOS), heat shock protein (HSP) 27, HSP60 and HSP70 in 25 cases of pleomorphic adenoma. Immunohistochemical staining for iNOS and HSPs was widely observed in neoplastic epithelia. In the stromal tissues, the cells showed both positive and negative staining with iNOS or HSPs. Staining for HSP27 was limited to the cytoplasm, and was more intense for HSP60 and 70. Both iNOS and HSPs were presumed to be localized mainly in myoepithelial cells in pleomorphic adenoma, and their localizations were mostly overlapped. These results indicated that iNOS and HSPs may be involved, at least in part, in the development of pleomorphic adenoma.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Immunohistochemical Study of the Localization of Inducible Nitric Oxide Synthase (iNOS) and Heat Shock Protein (HSP) in Pleomorphic Adenoma

Yamaguchi

Abiko

Nishimura

et al. 2004

Acta Histochem. Cytochem

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“…nNOS and eNOS are also called constitutive noS (cnoS). cnoS in constitutive form is effective on mediation of normal physiologic events, while elevated inoS expression is reported to be observed in pathological processes (2,3,5,12,22,24).…”

Section: Introductionmentioning

confidence: 99%