Expression of NF-κB-p65 and α-SMA in the Study of Capsules formed by Surface Textured Implants Versus Foam Covered Silicone Implants in a Rat Model

Possiedi, Rafael dib; Khoo, Lee Seng; Mazzarone, Francesco; Costa, Cleber Rafael Viera da; Stremel, Patricia

doi:10.52547/wjps.10.3.34

Cited by 1 publication

(5 citation statements)

References 32 publications

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“…48 Interestingly, polyurethane surfaces, when compared with other macrotextured devices, demonstrate higher expression of NFκB-p65, a component of the proinflammatory NF-κB transcription factor downstream of TNF-α. 16 Transforming Growth Factor-β TGF-β1 is a transcription factor that has both proinflammatory and antiinflammatory properties through activations of the SMAD, NF-κB and MAPK pathways. 49 TGF-β1 increases T helper cells' differentiation when joined by IL-6, and it promotes IL-9-and IL-10-producing T cells when combined with IL-4.…”

Section: Does Implant Texture Influence Inflammatory Mediators Of Cap...mentioning

confidence: 99%

“…38 Polyurethene macrotexturized and microtexturization 37,38 are associated with decreased trans-differentiation of fibroblasts to myofibroblasts relative to smooth implants. 16 Macrophages play an important role in the promotion of myofibroblast trans-differentiation of fibroblasts. 39,40 There are two subtypes of macrophages.…”

Section: How Does Implant Texture Affect Macrophage Behavior and Myof...mentioning

confidence: 99%

“…A silicone implant induces an inflammatory response characterized by infiltration of platelets, macrophages, foreign body giant cells, plasma cells, and lymphocytes. 16 This inflammatory cascade begins with the infiltration of platelets that produce transforming growth factor-β (TGF- β), platelet-derived growth factor, chemokine ligand 4, leukotriene, and interleukin-1 (IL-1). 17 , 18 These factors recruit and activate macrophages, which stimulate fibroblast recruitment, proliferation, and trans-differentiation into myofibroblasts.…”

Section: Normal Capsule Developmentmentioning

confidence: 99%

“… 38 Polyurethene macrotexturized and microtexturization 37 , 38 are associated with decreased trans-differentiation of fibroblasts to myofibroblasts relative to smooth implants. 16 …”

Section: How Does Implant Texture Affect Macrophage Behavior and Myof...mentioning

confidence: 99%

Section: Does Implant Texture Influence Inflammatory Mediators Of Cap...mentioning

confidence: 99%

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Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways

Wells,

Yang,

Edelstein-Keshet

et al. 2024

Plastic and Reconstructive Surgery - Global Open

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Background: Capsular contracture (CC) is a leading cause of morbidity in implant-based breast surgery. Implant surface texture has been implicated in CC development, yet its etiopathogenesis remains unclear. We conducted a systematic review to determine the influence of implant surface texture on cellular and molecular mechanisms involved in the etiopathogenesis of CC. Methods: A systematic review of the MEDLINE, Embase, Web of Science, and Scopus databases was completed to examine the influence of implant texture on cellular and molecular pathways leading to CC. Excluded articles were reviews and those examining solely the clinical presentation of CC. Results: Development of CC includes prolonged inflammation, increased myofibroblast density, parallel arrangement of collagen fibers, and biofilm formation. When compared with textured implants, smooth implants are associated with reduction in parallel collagen, capsule thickness, and sheer frictional force. Microtextured implants trigger a reduced macrophage response and decreased fibroblast activation as compared with smooth and macrotextured surfaces. Bacterial counts on microtextured and smooth surfaces are significantly lower than that of macrotextured surfaces. Both micro- and macrotextured implants have increased matrix metalloproteinases and activation of tumor necrosis factor α pathway, with increased activation of the transforming growth factor β1 pathway relative to smooth implants. Conclusions: Implant surface texture alters the cellular and molecular mechanisms in the chronic inflammatory process leading to CC. Given the complex biological system of cellular and molecular events in CC, a mathematical model integrating these influences may be optimal to deduce the etiopathogenesis.

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Section: Does Implant Texture Influence Inflammatory Mediators Of Cap...mentioning

confidence: 99%

Section: How Does Implant Texture Affect Macrophage Behavior and Myof...mentioning

confidence: 99%

Section: Normal Capsule Developmentmentioning

confidence: 99%

“… 38 Polyurethene macrotexturized and microtexturization 37 , 38 are associated with decreased trans-differentiation of fibroblasts to myofibroblasts relative to smooth implants. 16 …”

Section: How Does Implant Texture Affect Macrophage Behavior and Myof...mentioning

confidence: 99%

Section: Does Implant Texture Influence Inflammatory Mediators Of Cap...mentioning

confidence: 99%

See 3 more Smart Citations

Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways

Wells,

Yang,

Edelstein-Keshet

et al. 2024

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

Expression of NF-κB-p65 and α-SMA in the Study of Capsules formed by Surface Textured Implants Versus Foam Covered Silicone Implants in a Rat Model

Cited by 1 publication

References 32 publications

Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways

Implant Texture and Capsular Contracture: A Review of Cellular and Molecular Pathways

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