Expression of neuritin in human lung squamous cell carcinoma

Abstract

Background This study aimed to investigate the expression of neuritin in four common cancers, and to explore the association between neuritin expression and the occurrence and development of cancer. Methods We initially examined neuritin expression in human cervical, endometrial, oesophageal, and lung cancer tissues by immunohistochemistry (IHC). Based on these results, we further examined its expression in lung squamous cell carcinoma (LUSC) tissues by IHC and reverse transcription-polymerase chain reaction (RT-PCR). Results Neuritin expression levels were higher in all cancer tissues compared with normal control tissues. Neuritin protein and gene expression levels were significantly higher in LUSC tissues compared with normal lung tissues (P<0.001), according to IHC and RT-PCR, respectively. Neuritin expression levels decreased significantly with increased clinical TNM stage (I-IV) and distant metastasis (P<0.05). Conclusion Neuritin may have clinical value as a novel diagnostic and prognostic marker in patients with LUSC.

The functions of long non-coding RNA (lncRNA)-MALAT-1 in the pathogenesis of renal cell carcinoma

“…Numerous studies have revealed that long non-coding RNAs (lncRNAs) can function as oncogenes, tumor suppressors, or even exhibit dual roles, depending on the specific context and circumstances [ 25 ]. MALAT-1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) is a lncRNA that has been extensively studied in various cancers, including lung [ 26 ], colon [ 27 ], breast [ 28 ], ovary [ 29 ], gastric [ 30 ], bladder [ 31 ], and hepatic [ 32 ]. It is believed that MALAT-1 has been implicated in cancer cell migration, invasion, tumor progression, and metastasis in RCC [ 33 , 34 ].…”