Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients

Chen, Zhenguang; Wang, Tao; Hy, Luo; Lai, Yingrong; Yang, Xuhui; Li, Fugui; Lei, Yiyan; Su, Chunhua; Zhang, Xiuming; Lahn, Bruce T.; Xiang, Andy Peng

doi:10.1016/j.humpath.2009.10.018

Cited by 24 publications

(34 citation statements)

References 25 publications

(26 reference statements)

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“…On the other hand, no association with tumour grade was confirmed. This is not in agreement with either Chen or Ryuge findings 34,37 . The fact that we found no significant association of nestin expression with disease-free and overall survival is in contrast with common assumptions.…”

Section: Discussioncontrasting

confidence: 97%

“…This result does not resolve the discordance between the published study of Chen and co-workers 34 , who described significantly higher expression of nestin in adenocarcinomas, and Ryuge and co-workers 37 who reported higher positivity in squamous cell carcinoma. The differences could be explained by the use of different antibodies.…”

Section: Discussioncontrasting

confidence: 75%

“…Some studies suggest that nestin may play a role in the regulation of cell proliferation, survival and differentiation 35,36 . The expression of nestin in NSCLC cells was recently examined by Chen and co-workers 34 , but, in our opinion, extrapolation of their results is controversial, since these authors did not report whether the studied patients underwent preoperative radiotherapy and/or chemotherapy, and since they did not stratify patients according to tumour stage. Another recent paper on nestin expression in NSCLC described significantly higher expression of nestin in lymph node metastasis, in squamous cell carcinomas, in carcinomas with poorer differentiation, with vascular and lymphatic invasion and poorer prognosis, as well as with increased probability to die 37 .…”

Section: Introductionmentioning

confidence: 98%

“…Despite studies on the prognostic relevance of microvessel density in NSCLC (ref. [30][31][32][33][34] ), the significance of nestin expression in NSCLC vessels remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the prognostic impact of nestin expression in non-small cell lung cancer

Škarda¹,

Kolář²,

Janíková³

et al. 2012

BIOMED PAP

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Background. Nestin is an intermediary filament protein, expressed in progenitor cells of neural and muscle origin and in activated endothelium. The expression of this protein in tumours can be associated with degree of differentiation, biological potential and/or neoangiogenesis. Aims. The aim of this study was to examine the immunohistochemical expression of nestin in primary non-small cell lung carcinomas (NSCLC) and to determine its prognostic significance. Methods. Immunohistochemical detection of nestin was carried out on tissue microarrays constructed from 114 formalin-fixed and paraffin-embedded NSCLC samples. These included 78 squamous cell carcinomas and 37 adenocarcinomas. Expression of nestin was also analysed in 35 primary tumour independent NSCLC brain metastasis. The H-score and degree of nestin positive microvascularisation were determined. Both parameters correlated with the clinicopathological characteristics including disease-free and overall survival. Results. We demonstrated that expression of nestin is not significantly higher in tumour cells of adenocarcinomas than in sqamous cell carcinomas despite the fact that adenocarcinomas were more frequently positive (P≤0.30). On the other hand, nestin positivity and nestin positive neovascularisation were significantly more often found in stage IIIa tumours than tumours in stages I and II (P≤0.04, P≤0.02). Nestin expression was also significantly higher in brain metastases of squamous cell carcinomas than brain metastases of adenocarcinomas (P≤0.003). The expression of nestin, in general, did not significantly correspond to disease-free or overall survival. Conclusion. Nestin expression in NSCLCs is associated with poorer prognosis and with greater nestin-positive microvessel density.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 98%

“…Despite studies on the prognostic relevance of microvessel density in NSCLC (ref. [30][31][32][33][34] ), the significance of nestin expression in NSCLC vessels remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of the prognostic impact of nestin expression in non-small cell lung cancer

Škarda¹,

Kolář²,

Janíková³

et al. 2012

BIOMED PAP

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“…Although nestin is expressed during early stages of normal cells development, under pathological conditions this protein could be also found in cancer stem cells, as well as in perivascular and endothelial cells suggesting its role in various malignant tumors neoangiogenesis [11,12]. In recent years, an increased nestin expression has been reported in multiple malignant masses including CNS tumors, gastrointestinal stromal tumors, pancreatic cancer, prostate cancer, breast cancer, malignant melanomas, and thyroid tumors [13][14][15]. High expression of nestin correlated with aggressive growth, metastasis, and poor prognosis in these cancers.…”

Section: Introductionmentioning

confidence: 99%

Proliferation and maturation of intratumoral blood vessels in women with malignant ovarian tumors assessed with cancer stem cells marker nestin and platelet derived growth factor PDGF-B

et al. 2017

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Objectives: Platelet-derived growth factor B (PDGF-B) and nestin have been suggested to be useful in the assessment of neoangiogenesis in malignant ovarian masses. We aimed to investigate a possible association of these markers with newly formed microcapillaries and perivascular cells in ovarian tumors. Material and methods:Microvessel density (MVD) and pericytes were studied in 82 women with ovarian neoplasms, including 7 benign cysts, 7 borderline masses, 64 epithelial ovarian cancers and 4 other malignant ovarian tumors. Immunohistochemical staining included antibodies to CD34, PDGF-B and nestin. Conclusions:We conclude that the assessment of PDGF-B and nestin-positive MVD could be used to identify only highly active, angiogenic malignant ovarian masses, where tumor vasculature is formed.

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Tumor-Vascular Interactions in Non-Small Cell Lung Cancer

Ramnefjell

Akslen

2022

Biomarkers of the Tumor Microenvironment

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Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients

Cited by 24 publications

References 25 publications

Analysis of the prognostic impact of nestin expression in non-small cell lung cancer

Analysis of the prognostic impact of nestin expression in non-small cell lung cancer

Proliferation and maturation of intratumoral blood vessels in women with malignant ovarian tumors assessed with cancer stem cells marker nestin and platelet derived growth factor PDGF-B

Tumor-Vascular Interactions in Non-Small Cell Lung Cancer

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