Expression of naloxone-resistant β-endorphin binding sites on A20 cells: effects of concanavalin A and dexamethasone

Shaker, Mahmoud; Shahabi, Nahid; Sharp, Burt M.

doi:10.1016/0162-3109(94)90053-1

Cited by 13 publications

(3 citation statements)

References 23 publications

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“…Overall, finally, 38 years after establishment of the cell line, the present work provides the necessary genetic data to characterize A-20 as a model for human sporadic Burkitt’s lymphoma. In agreement with this, the successful previous use of dexamethasone, 10,32 concanavalin A, 9,33 and ruthenium complexes 10,34 for growth inhibition in this cell line and human sporadic Burkitt’s lymphoma was reported.…”

Section: Discussionsupporting

confidence: 80%

“…Nonetheless, even a test of medication meant for lymphoma treatment was done on this cell line, for example, for dexametason. 10,11…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, even a test of medication meant for lymphoma treatment was done on this cell line, for example, for dexametason. 10,11 Here, we present the first detailed molecular cytogenetic analyses of the cell line A-20. Multicolor-FISH using whole chromosome painting (wcp) probes and the FISH banding-approach "murine multicolor banding (mcb)" as well as array-comparative genomic hybridization (aCGH) were used, as previously reported.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Cytogenetic Characterization Identified the Murine B-Cell Lymphoma Cell Line A-20 as a Model for Sporadic Burkitt’s Lymphoma

Guja

Liehr

Rinčić

et al. 2017

J Histochem Cytochem.

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Here, we report the first molecular cytogenetic characterization of the BALB/cAnN mouse derived B-cell non-Hodgkin lymphoma (B-cell NHL) cell lines A-20. Even though previously used as a model for testing of, for example, dexametason, up to present, no data in the genetic properties of A-20 were available. The present study closed this gap and provides evidence that A-20 is a model for B-cell NHL subgroup sporadic Burkitt's lymphoma. C-myc oncogene is involved in a translocation and copy number alterations as gain of murine 14q material could be observed. Interestingly, the cell line showed the karyotype 39,X,-X or -Y,t(2;15)(qE5;qD2),del(6)(qB3qC3),del(9)(qA3qA4),dup(14)(qE1qE4) in ~95% of the cells, being exceptionally stable for cell lines being established 38 years ago. Still, ~5% of the cells showed polyploidization followed by chromothripsis. It remains to be determined if this can be observed also in other cell lines, just has not been reported yet, and/or if it is a unique feature of A-20. Overall, finally here, the necessary genetic data to identify A-20 as a model for human sporadic Burkitt's lymphoma are provided.

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Section: Discussionsupporting

confidence: 80%

“…Nonetheless, even a test of medication meant for lymphoma treatment was done on this cell line, for example, for dexametason. 10,11…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular Cytogenetic Characterization Identified the Murine B-Cell Lymphoma Cell Line A-20 as a Model for Sporadic Burkitt’s Lymphoma

Guja

Liehr

Rinčić

et al. 2017

J Histochem Cytochem.

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Effects of opioids on the immune system

1996

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Both therapeutic and chronic uses of opioids compromise the optimal functioning of the immune system. Overwhelming evidence suggests that opioid use affects both innate immunity and adaptive immunity. Chronic administration of opioids decreases the proliferative capacity of macrophage progenitor cells and lymphocytes. Additionally, the differentiated function of immune cells is significantly affected by opioids. These effects are mediated by either a direct action of opioids on the target cells or by indirect centrally mediated pathways. Molecular biological and biochemical characterization suggest that immune cells differentially express classical opioid receptors. Interestingly, these studies also reveal the presence of a novel class of opioid receptors in immune cells. We believe that this low affinity morphine binding site mediates the antiproliferative effects of morphine.

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The peptide molecular links between the central nervous and the immune systems

2005

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The central nervous system (CNS) and the immune system were for many years considered as two autonomous systems. Now, the reciprocal connections between them are generally recognized and very well documented. The links are realized mainly by various immuno- and neuropeptides. In the review the influence of the following immunopeptides on CNS is presented: tuftsin, thymulin, thymopoietin and thymopentin, thymosins, and thymic humoral factor. On the other side, the activity in the immune system of such neuropeptides as substance P, neurotensin, some neurokinins, enkephalins, and endorphins is discussed.

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Expression of naloxone-resistant β-endorphin binding sites on A20 cells: effects of concanavalin A and dexamethasone

Cited by 13 publications

References 23 publications

Molecular Cytogenetic Characterization Identified the Murine B-Cell Lymphoma Cell Line A-20 as a Model for Sporadic Burkitt’s Lymphoma

Molecular Cytogenetic Characterization Identified the Murine B-Cell Lymphoma Cell Line A-20 as a Model for Sporadic Burkitt’s Lymphoma

Effects of opioids on the immune system

The peptide molecular links between the central nervous and the immune systems

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