Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells

Chernov, Alexandr N.; Kim, Alexandr V.; Skliar, Sofia S.; Fedorov, Evgeniy V.; Tsapieva, Anna N.; Filatenkova, Tatiana A.; Chutko, Aleksei L.; Matsko, Marina V.; Galimova, Elvira. S.; Shamova, Olga V.

doi:10.1007/s00280-023-04622-8

Cited by 4 publications

(3 citation statements)

References 63 publications

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“…The effects of chemotherapy with LL-37 have been investigated in primary glioblastoma (GB) cell lines; treatment with the peptide alone showed high cytotoxicity to cancer cells, while the combination with chemotherapeutics [temozolomide (TMZ), doxorubicin (DOX), carboplatin (CB), cisplatin (CPL), and etoposide (ETO)] resulted in a synergistic effect. In addition to the encouraging results in vitro , administrations of LL-37 was able to inhibit tumor growth in a rat model of intracerebral GB, suggesting that the human cathelicidin has important anticancer activities that can be explored for the development of new therapeutic approaches against aggressive tumors ( Chernov et al, 2024 ).…”

Section: Cathelicidins and Cancer Therapymentioning

confidence: 99%

Recent advances in the therapeutic potential of cathelicidins

Guerra,

Vieira,

Calazans

et al. 2024

Front. Microbiol.

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The alarming increase in antimicrobial resistance in the last decades has prompted the search for alternatives to control infectious diseases. Antimicrobial peptides (AMPs) represent a heterogeneous class of molecules with ample antibacterial, antiviral, and antifungal effects. They can be found in many organisms, including all classes of vertebrates, providing a valuable source of new antimicrobial agents. The unique properties of AMPs make it harder for microbes develop resistance, while their immunomodulatory properties and target diversity reinforce their translational use in multiple diseases, from autoimmune disorders to different types of cancer. The latest years have witnessed a vast number of studies evaluating the use of AMPs in therapy, with many progressing to clinical trials. The present review explores the recent developments in the medicinal properties of cathelicidins, a vast family of AMPs with potent antimicrobial and immunomodulatory effects. Cathelicidins from several organisms have been tested in disease models of viral and bacterial infections, inflammatory diseases, and tumors, with encouraging results. Combining nanomaterials with active, natural antimicrobial peptides, including LL-37 and synthetic analogs like ceragenins, leads to the creation of innovative nanoagents with significant clinical promise. However, there are still important limitations, such as the toxicity of many cathelicidins to healthy host cells and low stability in vivo. The recent advances in nanomaterials and synthetic biology may help overcome the current limitations, enabling the use of cathelicidins in future therapeutics. Furthermore, a better understanding of the mechanisms of cathelicidin action in vivo and their synergy with other host molecules will contribute to the development of safer, highly effective therapies.

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Section: Cathelicidins and Cancer Therapymentioning

confidence: 99%

Recent advances in the therapeutic potential of cathelicidins

Guerra,

Vieira,

Calazans

et al. 2024

Front. Microbiol.

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“…Most antitumor drugs have an immunosuppressive effect, which can reduce the body’s defense function and make the body susceptible to bacterial infections, and there are some reports that the combined use of anticancer and antibacterial drugs can reduce bacterial invasion of cancer patients. , Naringenin (the chemical structure in Scheme ) is a flavonoid from the flavonoid group of polyphenols that is widely found in a variety of herbs and fruits. It has lots of biological activities, with antioxidant, anti-inflammatory, and anticancer effects .…”

Section: Introductionmentioning

confidence: 99%

Cocrystal of Naringenin and Norfloxacin: Crystal Transformation, Solubility, and Antibacterial and Anticancer Activities

Zeng,

Zheng,

Qiu

et al. 2024

Crystal Growth & Design

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Drug cocrystals can modulate the physical and chemical properties of drugs, even complement each other’s strengths, and have a synergistic enhancement effect. Here, we reported a drug cocrystal prepared by norfloxacin (NOR) and naringenin (NAR), comprising an antibacterial drug and an antitumor active pharmaceutical ingredient. The cocrystal hydrate obtained by crystal transformation methods enhanced the antibacterial activity of NOR against one Gram-positive bacterium (Staphylococcus aureus), three Gram-negative bacteria (Escherichia coli, Dysentery bacillus, Pseudomonas aeruginosa), and one fungus (Candida albicans), improved the solubility of NAR, reduced the hygroscopicity of NOR, and enhanced the anticancer activity of NAR against human breast cancer cells MDA-MB-231. This combination has potential therapeutic synergy in clinical terms.

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“…The effects of chemotherapy with LL-37 have been investigated in primary glioblastoma (GB) cell lines; treatment with the peptide alone showed high cytotoxicity to cancer cells, while the combination with chemotherapeutics [temozolomide (TMZ), doxorubicin (DOX), carboplatin (CB), cisplatin (CPL), and etoposide (ETO)] resulted in a synergistic effect. In addition to the encouraging results in vitro, administrations of LL-37 was able to inhibit tumor growth in a rat model of intracerebral GB, suggesting that the human cathelicidin has important anticancer activities that can be explored for the development of new therapeutic approaches against aggressive tumors (Chernov et al, 2024).…”

Section: Cathelicidins and Cancer Therapymentioning

confidence: 91%

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Expression of molecular markers and synergistic anticancer effects of chemotherapy with antimicrobial peptides on glioblastoma cells

Cited by 4 publications

References 63 publications

Recent advances in the therapeutic potential of cathelicidins

Recent advances in the therapeutic potential of cathelicidins

Cocrystal of Naringenin and Norfloxacin: Crystal Transformation, Solubility, and Antibacterial and Anticancer Activities

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