Expression of mitotic checkpoint proteins BUB1B and MAD2L1 in salivary duct carcinomas

Ko, Young Hyeh; Roh, Ji Hyeon; Son, Young‐Ik; Chung, Man Ki; Jang, Jeon Yeob; Byun, Hayoung; Baek, Chung‐Hwan; Jeong, Han‐Sin

doi:10.1111/j.1600-0714.2009.00835.x

Cited by 25 publications

(36 citation statements)

References 45 publications

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“…On the contrary, such studies that have investigated BUBR1 at the expression level have achieved more interesting albeit controversial results. BUBR1 was found to be upregulated in carcinomas of the lung, 16 colon, 12,17 stomach, 18,19 breast, 15,20 bladder, 21 kidney, 22 esophagus, 23 thyroid, 24 ovary, 25 salivary duct, 26 and liver. 27 In a number of these studies, overexpression of BUBR1 has been related not only to genomic complexity, 22 chromosomal instability, 15,20,21 DNA aneuploidy, 18,21 p53 expression, 27 and high cell proliferation, 17,19,21,27 but also to a more advanced pathologic stage, 21,25,27 a higher histologic grade, 21,22,25,27 presence of metastases, 18 and to a poor prognosis.…”

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confidence: 98%

BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival

et al. 2010

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BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival

et al. 2010

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“…High bubr1 expression was detected in 25.9% of subjects with salivary duct carcinoma (SDC), and high mad2l1 expression in 55.6% of them. However, survival analysis failed to show prognostic significance for SAC gene expression in SDCs, as well as for the other markers under analysis (Ko et al, 2010). The expression of bubr1 was studied by immunohistochemistry in 181 gastric cancer samples and by real-time PCR in several gastric cancer cell lines.…”

Section: Tumor Cells Frequently Show Altered Expression Levels Of Sacmentioning

confidence: 99%

The spindle assembly checkpoint: perspectives in tumorigenesis and cancer therapy

et al. 2011

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Loss or gain of chromosomes, a condition known as aneuploidy, is a common feature of tumor cells and has therefore been proposed as the driving force for tumorigenesis. Such chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter cells. In normal cells, missegregation is usually prevented by the spindle assembly checkpoint (SAC), a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle microtubules. Complete abrogation of SAC activity is lethal to normal as well as to tumor cells, as a consequence of massive chromosome mis-segregation. Importantly, many human aneuploid tumor cells exhibit a weakened SAC activity that allows them to tolerate gains or losses of a small number of chromosomes; and interfering with this SAC residual activity may constitute a suitable strategy to kill cancer cells. This review focuses on the potential link between SAC and tumorigenesis, and the therapeutic strategy to target the SAC for cancer treatment.

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“…Percentages for each alteration were obtained by totaling the number of positive cases (by IHC or sequencing for ErbB2, EGFR, AR) divided by total cases found in the literature [3, 4, 6, 7, 15, 18, 22, 28, 33, 39, 40, 44, 49–53, 55, 57–64, 67, 86–91]. Percentages representing expression are best estimates, as positivity was defined heterogeneously among studies.…”

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confidence: 99%

Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy

2017

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Salivary duct carcinoma (SDC) is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage. Previously, little was known about outcomes of this disease due to its rarity. In the past several years, much has been learned about salivary duct carcinoma after publication of outcomes from several large single-institution series and national database searches. Recent studies of genomic alterations have helped elucidate the biology and pathogenesis of this aggressive disease. Here we review outcomes of the disease, effects of treatment, prognostic factors, and genomic alterations in SDC. Studies of targeted therapy and promising future directions are also discussed.

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Expression of mitotic checkpoint proteins BUB1B and MAD2L1 in salivary duct carcinomas

Abstract: Mitotic checkpoint proteins appeared to play a limited role in predicting prognosis in SDCs. Further study is required to elucidate the exact role of mitotic checkpoint proteins in SDCs.

Cited by 25 publications

References 45 publications

BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival

BUBR1 expression in oral squamous cell carcinoma and its relationship to tumor stage and survival

The spindle assembly checkpoint: perspectives in tumorigenesis and cancer therapy

Salivary duct carcinoma: An aggressive salivary gland malignancy with opportunities for targeted therapy

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